COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.
COVID-19
Cytokines
Dendritic cells
Monocytes
Myeloid-derived suppressor cells
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
04
05
2022
received:
21
01
2022
accepted:
09
06
2022
pubmed:
11
6
2022
medline:
14
10
2022
entrez:
10
6
2022
Statut:
ppublish
Résumé
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
Identifiants
pubmed: 35689332
doi: 10.1002/eji.202249827
pmc: PMC9350042
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1676-1679Informations de copyright
© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
Références
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