Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort.
Behaviors
Body weight
Cannabis
Corpulence
Endocannabinoid system
Fibrosis
Hepatitis C, Chronic
Marijuana
Obesity
Δ9-Tetrahydrocannabinol
Journal
Journal of cannabis research
ISSN: 2522-5782
Titre abrégé: J Cannabis Res
Pays: England
ID NLM: 101752723
Informations de publication
Date de publication:
11 Jun 2022
11 Jun 2022
Historique:
received:
17
02
2022
accepted:
19
05
2022
entrez:
11
6
2022
pubmed:
12
6
2022
medline:
12
6
2022
Statut:
epublish
Résumé
Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37-0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19-0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38-0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure. ClinicalTrials.gov identifier: NCT01953458 .
Sections du résumé
BACKGROUND
BACKGROUND
Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection.
METHODS
METHODS
Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models.
RESULTS
RESULTS
Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37-0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19-0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38-0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI.
CONCLUSIONS
CONCLUSIONS
We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure.
TRIAL REGISTRATION
BACKGROUND
ClinicalTrials.gov identifier: NCT01953458 .
Identifiants
pubmed: 35690798
doi: 10.1186/s42238-022-00138-9
pii: 10.1186/s42238-022-00138-9
pmc: PMC9188079
doi:
Banques de données
ClinicalTrials.gov
['NCT01953458']
Types de publication
Journal Article
Langues
eng
Pagination
31Investigateurs
Laurent Alric
(L)
Chloe Pomes
(C)
Fabien Zoulim
(F)
Marianne Maynard
(M)
Roxane Bai
(R)
Lucie Hucault
(L)
François Bailly
(F)
François Raffi
(F)
Eric Billaud
(E)
David Boutoille
(D)
Maeva Lefebvre
(M)
Elisabeth André-Garnier
(E)
Paul Cales
(P)
Isabelle Hubert
(I)
Adrien Lannes
(A)
Françoise Lunel
(F)
Jérôme Boursier
(J)
Tarik Asselah
(T)
Nathalie Boyer
(N)
Nathalie Giuily
(N)
Corinne Castelnau
(C)
Giovanna Scoazec
(G)
Stanislas Pol
(S)
Hélène Fontaine
(H)
Emilie Rousseaud
(E)
Anaïs Vallet-Pichard
(A)
Philippe Sogni
(P)
Victor de Ledinghen
(V)
Juliette Foucher
(J)
Jean-Baptiste Hiriart
(JB)
Jancell M'Bouyou
(J)
Marie Irlès-Depé
(M)
Marc Bourlière
(M)
Si Nafa Si Ahmed
(SNS)
Valérie Oules
(V)
Albert Tran
(A)
Rodolphe Anty
(R)
Eve Gelsi
(E)
Régine Truchi
(R)
Dominique Thabut
(D)
Saloua Hammeche
(S)
Joseph Moussali
(J)
Xavier Causse
(X)
Barbara De Dieuleveult
(B)
Brahim Ouarani
(B)
Damien Labarrière
(D)
Nathalie Ganne
(N)
Véronique Grando-Lemaire
(V)
Pierre Nahon
(P)
Séverine Brulé
(S)
Betul Ulker
(B)
Dominique Guyader
(D)
Caroline Jezequel
(C)
Audrey Brener
(A)
Anne Laligant
(A)
Aline Rabot
(A)
Isabelle Renard
(I)
François Habersetzer
(F)
Thomas F Baumert
(TF)
Michel Doffoel
(M)
Catherine Mutter
(C)
Pauline Simo-Noumbissie
(P)
Esma Razi
(E)
Jean-Pierre Bronowicki
(JP)
Hélène Barraud
(H)
Mouni Bensenane
(M)
Abdelbasset Nani
(A)
Sarah Hassani-Nani
(S)
Marie-Albertine Bernard
(MA)
Georges-Philippe Pageaux
(GP)
Dominique Larrey
(D)
Magda Meszaros
(M)
Sophie Metivier
(S)
Christophe Bureau
(C)
Thibault Morales
(T)
Jean Marie Peron
(JM)
Marie Angèle Robic
(MA)
Thomas Decaens
(T)
Marine Faure
(M)
Bruno Froissart
(B)
Marie-Noelle Hilleret
(MN)
Jean-Pierre Zarski
(JP)
Ghassan Riachi
(G)
Odile Goria
(O)
Fatima Paris
(F)
Hélène Montialoux
(H)
Vincent Leroy
(V)
Giuliana Amaddeo
(G)
Anne Varaut
(A)
Mélanie Simoes
(M)
Rachida Amzal
(R)
Olivier Chazouillières
(O)
Tony Andreani
(T)
Bénédicte Angoulevant
(B)
Azeline Chevance
(A)
Lawrence Serfaty
(L)
Didier Samuel
(D)
Teresa Antonini
(T)
Audrey Coilly
(A)
Jean-Charles Duclos-Vallée
(JC)
Mariagrazia Tateo
(M)
Armand Abergel
(A)
Maud Reymond
(M)
Chanteranne Brigitte
(C)
Buchard Benjamin
(B)
Léon Muti
(L)
Claire Geist
(C)
Guillaume Conroy
(G)
Raphaëlle Riffault
(R)
Isabelle Rosa
(I)
Camille Barrault
(C)
Laurent Costes
(L)
Hervé Hagège
(H)
Véronique Loustaud-Ratti
(V)
Paul Carrier
(P)
Maryline Debette-Gratien
(M)
Philippe Mathurin
(P)
Guillaume Lassailly
(G)
Elise Lemaitre
(E)
Valérie Canva
(V)
Sébastien Dharancy
(S)
Alexandre Louvet
(A)
Anne Minello
(A)
Marianne Latournerie
(M)
Marc Bardou
(M)
Thomas Mouillot
(T)
Louis D'Alteroche
(L)
Didier Barbereau
(D)
Charlotte Nicolas
(C)
Laure Elkrief
(L)
Anaïs Jaillais
(A)
Jérôme Gournay
(J)
Caroline Chevalier
(C)
Isabelle Archambeaud
(I)
Sarah Habes
(S)
Isabelle Portal
(I)
Moana Gelu-Simeon
(M)
Eric Saillard
(E)
Marie-Josée Lafrance
(MJ)
Lucie Catherine
(L)
Fabrice Carrat
(F)
Frederic Chau
(F)
Céline Dorival
(C)
Isabelle Goderel
(I)
Clovis Lusivika-Nzinga
(C)
Marc-Antoine Bellance
(MA)
Jonathan Bellet
(J)
Priscilla Monfalet
(P)
Jessica Chane-Teng
(J)
Sephora Bijaoui
(S)
Grégory Pannetier
(G)
François Téoulé
(F)
Jérôme Nicol
(J)
Florian Sebal
(F)
Rafika Bekhti
(R)
Carole Cagnot
(C)
Anaïs Boston
(A)
Laura Nailler
(L)
Guillaume Le Meut
(G)
Alpha Diallo
(A)
Ventzislava Petrov-Sanchez
(V)
Marc Bourlière
(M)
Jérôme Boursier
(J)
Fabrice Carrat
(F)
Patrizia Carrieri
(P)
Elisabeth Delarocque-Astagneau
(E)
Victor De Ledinghen
(V)
Céline Dorival
(C)
Hélène Fontaine
(H)
Slim Fourati
(S)
Chantal Housset
(C)
Dominique Larrey
(D)
Pierre Nahon
(P)
Georges-Philippe Pageaux
(GP)
Ventzislava Petrov-Sanchez
(V)
Stanislas Pol
(S)
Mathias Bruyand
(M)
Linda Wittkop
(L)
Fabien Zoulim
(F)
Jessica Zucman-Rossi
(J)
Marianne L'hennaff
(M)
Michèle Sizorn
(M)
Carole Cagnot
(C)
Informations de copyright
© 2022. The Author(s).
Références
Cannabis Cannabinoid Res. 2021 Oct 13;:
pubmed: 34648718
Int J Obes (Lond). 2016 Nov;40(11):1794-1801
pubmed: 27377952
Diabetes Care. 2006 Jul;29(7):1585-90
pubmed: 16801583
J Viral Hepat. 2020 Dec;27(12):1473-1483
pubmed: 32810343
World J Gastroenterol. 2021 Apr 7;27(13):1267-1282
pubmed: 33833481
Nat Rev Endocrinol. 2020 Mar;16(3):177-189
pubmed: 32020062
Molecules. 2021 Oct 13;26(20):
pubmed: 34684760
Front Med (Lausanne). 2021 Oct 18;8:744512
pubmed: 34733865
J Clin Gastroenterol. 2004 Sep;38(8):705-9
pubmed: 15319656
Addiction. 2021 May;116(5):1000-1010
pubmed: 33160291
J Hepatol. 2017 Jan;66(1):39-47
pubmed: 27622858
PLoS One. 2015 Dec 03;10(12):e0144270
pubmed: 26633823
Addict Biol. 2021 Nov;26(6):e13061
pubmed: 34028926
Front Plant Sci. 2019 Jan 09;9:1969
pubmed: 30687364
Pak J Pharm Sci. 2013 Nov;26(6):1251-7
pubmed: 24191335
Liver Int. 2010 Oct;30(9):1259-69
pubmed: 20633102
Eur J Pharmacol. 2013 Sep 5;715(1-3):46-55
pubmed: 23838456
Hepatology. 2007 Jul;46(1):32-6
pubmed: 17567829
Molecules. 2021 Jul 28;26(15):
pubmed: 34361704
Int J Mol Sci. 2015 Mar 27;16(4):7057-76
pubmed: 25826533
Am J Epidemiol. 2007 Jul 15;166(2):196-203
pubmed: 17496314
BMC Med. 2016 Oct 21;14(1):166
pubmed: 27769239
Nutr Diabetes. 2013 May 27;3:e68
pubmed: 23712280
Liver Int. 2021 Sep;41(9):2059-2067
pubmed: 33894103
Front Psychiatry. 2016 Jul 05;7:104
pubmed: 27458388
Drug Alcohol Depend. 2021 Sep 1;226:108863
pubmed: 34304124
Sci Rep. 2021 Feb 19;11(1):4286
pubmed: 33608628
Epidemiol Rev. 2007;29:6-28
pubmed: 17510091
Int J Epidemiol. 2019 Oct 1;48(5):1695-1700
pubmed: 30879064
J Viral Hepat. 2021 Sep;28(9):1284-1292
pubmed: 34105867
Clin Liver Dis. 2017 Aug;21(3):475-486
pubmed: 28689587
Antioxidants (Basel). 2019 Dec 25;9(1):
pubmed: 31881765
Cannabis Cannabinoid Res. 2020 Sep 02;5(3):246-254
pubmed: 32923661
Nutrients. 2020 Oct 26;12(11):
pubmed: 33114564
PLoS One. 2014 Nov 21;9(11):e113677
pubmed: 25415265
ISRN Obes. 2013 Jan 27;2013:314295
pubmed: 24533220
J Hepatol. 2018 Apr;68(4):845-847
pubmed: 29104123
J Viral Hepat. 2011 Feb;18(2):135-41
pubmed: 20497310
Arch Med Sci. 2017 Jun;13(4):851-863
pubmed: 28721154
J Clin Med. 2021 Jan 20;10(3):
pubmed: 33498537
World J Gastroenterol. 2021 Feb 7;27(5):404-415
pubmed: 33584072
Clin Pharmacol Ther. 2011 Jul;90(1):164-8
pubmed: 21633341
Nutrients. 2021 May 11;13(5):
pubmed: 34064937
Cannabis Cannabinoid Res. 2021 Jun;6(3):177-195
pubmed: 33998900
Hepatology. 2003 Sep;38(3):639-44
pubmed: 12939590
AIDS. 2020 May 1;34(6):953-954
pubmed: 32271254
Cannabis Cannabinoid Res. 2022 Apr;7(2):135-151
pubmed: 34242511
Expert Rev Anti Infect Ther. 2021 Sep;19(9):1147-1156
pubmed: 33538612
Biomed Pharmacother. 2021 Aug;140:111639
pubmed: 34091179
Liver Cancer. 2021 Jul;10(4):309-319
pubmed: 34414119
PLoS One. 2017 May 16;12(5):e0177151
pubmed: 28510579
Eur J Public Health. 2014 Aug;24 Suppl 1:31-9
pubmed: 25107996
Can J Gastroenterol. 2008 Apr;22(4):376-80
pubmed: 18414712
Can J Gastroenterol Hepatol. 2018 Sep 23;2018:9430953
pubmed: 30345261
Metabol Open. 2021 Mar 26;10:100090
pubmed: 33889834
J Hepatol. 2017 Dec;67(6):1157-1167
pubmed: 28942916
Front Endocrinol (Lausanne). 2020 Mar 04;11:114
pubmed: 32194509
Obesity (Silver Spring). 2015 Feb;23(2):290-5
pubmed: 25557382
Circulation. 2005 Oct 25;112(17):2735-52
pubmed: 16157765
Dig Dis Sci. 2021 Jul;66(7):2394-2406
pubmed: 32654086
Curr Diab Rep. 2016 Nov;16(11):117
pubmed: 27747490
Diabetes Care. 2016 Oct;39(10):1777-86
pubmed: 27573936
Curr Diab Rep. 2019 Nov 4;19(11):117
pubmed: 31686231
Adv Nutr. 2021 Jul 30;12(4):1137-1148
pubmed: 33427291
Am J Public Health. 2016 Sep;106(9):1656-62
pubmed: 27459460
Cannabis Cannabinoid Res. 2018 Dec 21;3(1):259-271
pubmed: 30671538
Psychosom Med. 2019 Apr;81(3):281-288
pubmed: 30589665
Liver Int. 2018 Feb;38 Suppl 1:139-145
pubmed: 29427487
Hepatology. 2006 Jun;43(6):1317-25
pubmed: 16729309
J Cannabis Res. 2020 Jan 31;2(1):6
pubmed: 33526143
Rev Endocr Metab Disord. 2022 Jun;23(3):401-420
pubmed: 34460075
Cad Saude Publica. 2019 Oct 14;35(10):e00125518
pubmed: 31618383