Eurotium cristatum reduces obesity by alleviating gut microbiota dysbiosis and modulating lipid and energy metabolism.
Eurotium cristatum
gut microbiota
high fat
lipid and energy metabolism
Journal
Journal of the science of food and agriculture
ISSN: 1097-0010
Titre abrégé: J Sci Food Agric
Pays: England
ID NLM: 0376334
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
09
05
2022
received:
11
02
2022
accepted:
11
06
2022
pubmed:
13
6
2022
medline:
4
11
2022
entrez:
12
6
2022
Statut:
ppublish
Résumé
Fuzhuan brick tea (FBT) has been shown to prevent obesity, but little is known about the effect of Eurotium cristatum, a critical fungus from FBT. This study examined the effects of live E. cristatum on lipid metabolism and gut microbiota composition in high-fat (HF) diet-induced obese mice. Male HF diet-fed mice were treated with E. cristatum for 12 weeks. The results showed that E. cristatum administration caused strong inhibition against HF-induced body weight gain, dyslipidemia and liver oxidative stress damage. Additionally, Firmicutes and Bacteroidetes in phylum level and six types of bacterial including short-chain fatty acids (SCFAs) producing bacteria in genus level were found to be significantly changed in E. cristatum treated mice as compared to HF fed mice. As expected, E. cristatum could increase total SCFAs levels in feces. Interestingly, E. cristatum markedly increased the proportion of Akkermansia to resist obesity. Functional prediction analysis indicated that E. cristatum changed lipid and energy metabolism. Furthermore, E. cristatum ingestion can modulate hepatic acetyl-coa carboxylase (ACC), fatty acid synthase (FAS), sterol-regulatory element binding protein-1 (SREBP-1) and adipose uncoupling protein-1 (UCP-1) expression. Conclusively, these findings suggest that E. cristatum can prevent the HF-induced lipid accumulation and other complications by modulating gut microbiota, lipid and energy metabolism. © 2022 Society of Chemical Industry.
Sections du résumé
BACKGROUND
BACKGROUND
Fuzhuan brick tea (FBT) has been shown to prevent obesity, but little is known about the effect of Eurotium cristatum, a critical fungus from FBT. This study examined the effects of live E. cristatum on lipid metabolism and gut microbiota composition in high-fat (HF) diet-induced obese mice.
RESULTS
RESULTS
Male HF diet-fed mice were treated with E. cristatum for 12 weeks. The results showed that E. cristatum administration caused strong inhibition against HF-induced body weight gain, dyslipidemia and liver oxidative stress damage. Additionally, Firmicutes and Bacteroidetes in phylum level and six types of bacterial including short-chain fatty acids (SCFAs) producing bacteria in genus level were found to be significantly changed in E. cristatum treated mice as compared to HF fed mice. As expected, E. cristatum could increase total SCFAs levels in feces. Interestingly, E. cristatum markedly increased the proportion of Akkermansia to resist obesity. Functional prediction analysis indicated that E. cristatum changed lipid and energy metabolism. Furthermore, E. cristatum ingestion can modulate hepatic acetyl-coa carboxylase (ACC), fatty acid synthase (FAS), sterol-regulatory element binding protein-1 (SREBP-1) and adipose uncoupling protein-1 (UCP-1) expression.
CONCLUSION
CONCLUSIONS
Conclusively, these findings suggest that E. cristatum can prevent the HF-induced lipid accumulation and other complications by modulating gut microbiota, lipid and energy metabolism. © 2022 Society of Chemical Industry.
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7039-7051Subventions
Organisme : key research and development plan in Shaanxi province, China
ID : 2020 ZDLSF01-07
Organisme : key research and development plan in Shaanxi province, China
ID : 2021 NY-184
Organisme : National Natural Science Foundation of China
ID : 31871752
Organisme : National Natural Science Foundation of China
ID : 31901647
Organisme : National Natural Science Foundation of China
ID : 32072175
Organisme : the 65th project funded by China postdoctoral science foundation
ID : 2019 M650255
Organisme : the Development Program for Innovative Research Team of Shaanxi Normal University
ID : GK 202101006
Organisme : the Fundamental Research Funds for the Central Universities of Shaanxi Normal University
ID : GK 201803074
Organisme : the Fundamental Research Funds for the Central Universities of Shaanxi Normal University
ID : GK 2020-1601021041
Organisme : the Fundamental Research Funds for the Central Universities of Shaanxi Normal University
ID : GK 202103100
Organisme : the Sci-Tech Innovation Team of Shaanxi Province, China
ID : 2019 TD-035
Informations de copyright
© 2022 Society of Chemical Industry.
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