Higher viral load of Epstein-Barr virus in gastric cancer compared with non-cancerous gastroduodenal tissues.
Epstein-Barr virus
Helicobacter pylori
cancer
gastric cancer
gastroduodenal disease
Journal
Le infezioni in medicina
ISSN: 2532-8689
Titre abrégé: Infez Med
Pays: Italy
ID NLM: 9613961
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
03
2022
accepted:
26
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Epstein-Barr Virus (EBV)-associated gastric cancer is a distinct molecular subtype of gastrointestinal carcinomas as defined by the Cancer Genome Atlas. In the present study 237 samples from Iranian patients diagnosed with gastric cancer and gastroduodenal disease were retrospectively examined for EBV infection by quantitative Real-Time PCR. Of the 237 samples tested, EBV DNA was detected in 37 samples (15.6%), in 13 of the 81 gastric cancer cases (16%), and 24 of the 156 non-cancerous samples (15.4%). The EBV infection rate was found higher in patients with gastric ulcer (35%) and duodenal ulcer (21.9%) compared to patients with gastric cancer (16%) and gastritis (19.6%). The EBV-encoded small RNA (EBER) copy number in the gastric cancer group (mean = 2.14×10 The higher number of copies of EBV-EBER in the gastric cancer group compared to the non-cancer group confirmed the possible role of EBV in inducing cancer.
Identifiants
pubmed: 35693058
doi: 10.53854/liim-3002-12
pii: 1124-9390_30_2_2022_263-271
pmc: PMC9177184
doi:
Types de publication
Journal Article
Langues
eng
Pagination
263-271Informations de copyright
Copyright © 2016 - 2022 InfezMed.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no financial or commercial conflict of interest.
Références
Cancer Epidemiol Biomarkers Prev. 2014 May;23(5):700-13
pubmed: 24618998
Asian Pac J Cancer Prev. 2012;13(4):1261-6
pubmed: 22799315
Mol Med Rep. 2019 Mar;19(3):2125-2136
pubmed: 30747208
World J Gastroenterol. 2008 Feb 14;14(6):884-91
pubmed: 18240345
Pathogens. 2020 Feb 06;9(2):
pubmed: 32041355
Viruses. 2014 Jan 20;6(1):301-18
pubmed: 24448220
Infect Agent Cancer. 2017 Jul 19;12:41
pubmed: 28814970
PLoS One. 2015 Oct 13;10(10):e0140178
pubmed: 26460692
Pathol Oncol Res. 2016 Oct;22(4):667-72
pubmed: 26879397
J Oncol. 2019 Dec 06;2019:1785132
pubmed: 31885568
Infect Drug Resist. 2018 Dec 13;11:2545-2554
pubmed: 30588039
J Prev Med Public Health. 2016 Mar;49(2):97-107
pubmed: 27055546
J Glob Oncol. 2019 Sep;5:1-9
pubmed: 31479342
Hum Pathol. 1996 Jan;27(1):20-7
pubmed: 8543306
J Med Virol. 2020 Mar;92(3):356-363
pubmed: 31663617
Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):461-73
pubmed: 11313005
Clin Infect Dis. 2003 Nov 1;37(9):1244-9
pubmed: 14557970
Gastroenterology. 1997 Dec;113(6):1983-91
pubmed: 9394739
Diagn Pathol. 2007 Jul 15;2:25
pubmed: 17629938
BMC Cancer. 2020 Jun 1;20(1):493
pubmed: 32487043
Dig Dis Sci. 2021 Apr;66(4):1220-1226
pubmed: 32367248
J Gastroenterol Hepatol. 2020 Sep;35(9):1495-1502
pubmed: 32181516
J Med Microbiol. 2006 Jul;55(Pt 7):905-911
pubmed: 16772418
Scand J Surg. 2006;95(4):218-24
pubmed: 17249268
N Engl J Med. 2004 Jun 10;350(24):2461-70
pubmed: 15190138
World J Gastroenterol. 2018 Nov 21;24(43):4928-4938
pubmed: 30487702
World J Gastroenterol. 2010 Jan 21;16(3):312-9
pubmed: 20082476
Arch Virol. 2015 Jan;160(1):61-8
pubmed: 25218012
Medicine (Baltimore). 2019 Jan;98(3):e14124
pubmed: 30653141
World J Gastroenterol. 2005 Oct 21;11(39):6096-103
pubmed: 16273633
Scand J Gastroenterol. 2008;43(6):669-74
pubmed: 18569983
Microorganisms. 2019 Sep 01;7(9):
pubmed: 31480554
Clin Cancer Res. 2011 May 1;17(9):2885-92
pubmed: 21478335
Nat Rev Cancer. 2016 Dec;16(12):789-802
pubmed: 27687982
Asian Pac J Cancer Prev. 2016;17(5):2423-8
pubmed: 27268608
Arch Iran Med. 2014 Nov;17(11):767-70
pubmed: 25365618
J Gastroenterol Hepatol. 2017 Jan;32(1):82-91
pubmed: 27144885
Gut. 1993 Dec;34(12):1672-6
pubmed: 8282253
Lab Invest. 2009 Jan;89(1):80-90
pubmed: 19002111
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Clin Gastroenterol Hepatol. 2020 Mar;18(3):534-542
pubmed: 31362118
BMC Gastroenterol. 2014 Oct 15;14:179
pubmed: 25318991