Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the
Colon cancer
FAP
ONC201
TIC10
TRAIL
chemoprevention
colon polyp
min mouse
Journal
American journal of cancer research
ISSN: 2156-6976
Titre abrégé: Am J Cancer Res
Pays: United States
ID NLM: 101549944
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
12
2021
accepted:
02
03
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Colorectal cancer (CRC) incidence is rising globally. Hence, preventing this disease is a high priority. With this aim, we determined the CRC prevention potential of the TRAIL-inducing small molecule ONC201/TIC10 using a preclinical model representing high-risk familial adenomatous polyposis (FAP) patients,
Types de publication
Journal Article
Langues
eng
Pagination
2118-2131Informations de copyright
AJCR Copyright © 2022.
Déclaration de conflit d'intérêts
W.S.E-D. is a co-founder of Oncoceutics, Inc., a subsidiary of Chimerix. Dr. El-Deiry has disclosed his relationship with Oncoceutics and potential conflict of interest to his academic institution/employer and is fully compliant with NIH and institutional policy that is managing this potential conflict of interest. Other authors have no potential conflicts of interest.
Références
Mol Cancer. 2015 May 01;14:99
pubmed: 25927855
Nutr Cancer. 2002;43(1):1-21
pubmed: 12467130
N Engl J Med. 2013 Sep 19;369(12):1095-105
pubmed: 24047059
Int J Mol Sci. 2021 Jun 09;22(12):
pubmed: 34207660
Curr Med Chem. 2010;17(29):3309-17
pubmed: 20712573
J Cancer Epidemiol. 2019 Nov 11;2019:9841295
pubmed: 31827515
BMJ. 1998 Dec 12;317(7173):1636-40
pubmed: 9848907
Sci Transl Med. 2013 Feb 6;5(171):171ra17
pubmed: 23390247
Neoplasia. 2001 Nov-Dec;3(6):535-46
pubmed: 11774036
Cancer Manag Res. 2015 Jan 14;7:19-35
pubmed: 25609998
Oncotarget. 2016 Nov 8;7(45):74380-74392
pubmed: 27602582
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Trends Cancer. 2020 Dec;6(12):989-1001
pubmed: 32718904
Dis Model Mech. 2014 Nov;7(11):1215-25
pubmed: 25288683
Cancer Cell. 2019 May 13;35(5):707-708
pubmed: 31085171
Immunology. 2009 Jun;127(2):145-54
pubmed: 19476510
Clin Cancer Res. 2017 Aug 1;23(15):4163-4169
pubmed: 28331050
Cell Death Differ. 2003 Jan;10(1):66-75
pubmed: 12655296
PLoS One. 2015 Aug 25;10(8):e0135959
pubmed: 26305323
Hepatology. 2001 Jul;34(1):3-6
pubmed: 11431726
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cancer Cell. 2019 May 13;35(5):721-737.e9
pubmed: 31056398
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
PLoS One. 2015 Nov 18;10(11):e0143082
pubmed: 26580220
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Eur J Immunol. 2021 May;51(5):1246-1261
pubmed: 33442873
Cancer Prev Res (Phila). 2011 Dec;4(12):2015-26
pubmed: 21885812
Neoplasia. 2021 Jun;23(6):574-583
pubmed: 34091121
Cancer Res. 2015 Apr 1;75(7):1423-32
pubmed: 25712124