Clinical characteristics, surgical treatments, prognosis, and prognostic factors of primary tracheal cancer patients: 20-year data of the National Cancer Center, China.
Tracheal cancer
clinicopathological features
surgery
survival
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
12
10
2021
accepted:
18
05
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
14
6
2022
Statut:
ppublish
Résumé
Tracheal cancer is a rare malignancy of which previous reports are mostly case reports or small series. Herein, we sought to evaluate the clinical characteristics, surgical treatments, and prognosis of surgically treated primary tracheal cancer patients. Patients with primary tracheal cancer who had received surgery in our center between January 2000 and December 2020 were enrolled. Clinical and surgical features were collected by retrospective review of medical records and follow-up was done by telephone interview. The statistical tests were two-sided. A total of 128 patients were included in the study, 49.2% of whom were male, and the average age was 49.4±13.6 years. The most common histological subtype was adenoid cystic carcinoma (ACC; 78/128, 60.9%) followed by squamous cell carcinoma (SCC; 24/128, 18.8%). The percentage of tumors located in the cervical trachea, thoracic trachea, and carina were 50%, 41.4%, and 8.6%, respectively. Among those analyzed, 32.0% of the primary tumors had invaded adjacent organs (E2 disease) and 7.8% of patients had lymph node involvement. Tracheal resection plus reconstruction (with or without thyroidectomy) was the predominant surgical procedure, followed by carinal resection with neocarina. Radical resection (R0) was performed on 61.7% of patients and 63 (49.2%) patients received adjuvant therapy. Compared to ACC, SCC patients had significantly higher risk of tumor of the carina, nodal metastasis, and complications. The 5-year overall survival (OS) for the entire cohort was 84.5% and factors associated with poor prognosis included carinal tumor [hazard ratio (HR) =10.206; P<0.001], E2 disease (HR =8.870; P=0.001), lymph node metastasis (HR =15.197; P<0.001), and postoperative complications (HR =12.497; P=0.001). The two major subtypes of tracheal cancer are ACC and SCC. Tumor location, extension, lymph node metastasis and complication are survival related factors for surgically treated patients.
Sections du résumé
Background
UNASSIGNED
Tracheal cancer is a rare malignancy of which previous reports are mostly case reports or small series. Herein, we sought to evaluate the clinical characteristics, surgical treatments, and prognosis of surgically treated primary tracheal cancer patients.
Methods
UNASSIGNED
Patients with primary tracheal cancer who had received surgery in our center between January 2000 and December 2020 were enrolled. Clinical and surgical features were collected by retrospective review of medical records and follow-up was done by telephone interview. The statistical tests were two-sided.
Results
UNASSIGNED
A total of 128 patients were included in the study, 49.2% of whom were male, and the average age was 49.4±13.6 years. The most common histological subtype was adenoid cystic carcinoma (ACC; 78/128, 60.9%) followed by squamous cell carcinoma (SCC; 24/128, 18.8%). The percentage of tumors located in the cervical trachea, thoracic trachea, and carina were 50%, 41.4%, and 8.6%, respectively. Among those analyzed, 32.0% of the primary tumors had invaded adjacent organs (E2 disease) and 7.8% of patients had lymph node involvement. Tracheal resection plus reconstruction (with or without thyroidectomy) was the predominant surgical procedure, followed by carinal resection with neocarina. Radical resection (R0) was performed on 61.7% of patients and 63 (49.2%) patients received adjuvant therapy. Compared to ACC, SCC patients had significantly higher risk of tumor of the carina, nodal metastasis, and complications. The 5-year overall survival (OS) for the entire cohort was 84.5% and factors associated with poor prognosis included carinal tumor [hazard ratio (HR) =10.206; P<0.001], E2 disease (HR =8.870; P=0.001), lymph node metastasis (HR =15.197; P<0.001), and postoperative complications (HR =12.497; P=0.001).
Conclusions
UNASSIGNED
The two major subtypes of tracheal cancer are ACC and SCC. Tumor location, extension, lymph node metastasis and complication are survival related factors for surgically treated patients.
Identifiants
pubmed: 35693280
doi: 10.21037/tlcr-22-258
pii: tlcr-11-05-735
pmc: PMC9186175
doi:
Types de publication
Journal Article
Langues
eng
Pagination
735-743Informations de copyright
2022 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-22-258/coif). MVI serves as an unpaid editorial board member of Translational Lung Cancer Research from October 2021 to September 2023. The other authors have no conflicts of interest to declare.
Références
Laryngoscope. 2020 Feb;130(2):405-412
pubmed: 30977524
Eur J Cardiothorac Surg. 2017 Aug 1;52(2):392-394
pubmed: 28633347
Ann Thorac Surg. 2019 Sep;108(3):873-882
pubmed: 31026435
Ann Thorac Surg. 2021 Mar;111(3):1093-1094
pubmed: 32710844
Lancet Oncol. 2006 Jan;7(1):83-91
pubmed: 16389188
Am J Otolaryngol. 2017 Nov - Dec;38(6):673-677
pubmed: 28927948
Ann Thorac Surg. 2021 Mar;111(3):1094
pubmed: 33189671
Eur J Surg Oncol. 2020 Oct;46(10 Pt A):1888-1895
pubmed: 32418755
Lung Cancer. 2019 Jun;132:87-93
pubmed: 31097099
Am J Clin Oncol. 2011 Feb;34(1):32-7
pubmed: 20087156
Otolaryngol Head Neck Surg. 2004 Nov;131(5):639-42
pubmed: 15523440
J Surg Oncol. 2017 Jun;115(8):1004-1010
pubmed: 28407313
Ann Surg Oncol. 2007 Feb;14(2):968-76
pubmed: 17139460
Ann Thorac Surg. 2020 Sep;110(3):1012-1022
pubmed: 32335015
Eur J Cardiothorac Surg. 2003 Jan;23(1):1-5
pubmed: 12493495