IL-38 Gene Deletion Worsens Murine Colitis.
IBD – inflammatory bowel diseases
IL-1α
IL-1β
IL-38
NLRP3
colitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
12
2021
accepted:
26
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
15
6
2022
Statut:
epublish
Résumé
IL-38 is a recently discovered cytokine and member of the IL-1 Family. In the IL-1 Family, IL-38 is unique because the cytokine is primarily a B lymphocyte product and functions to suppress inflammation. Studies in humans with inflammatory bowel disease (IBD) suggest that IL-38 may be protective for ulcerative colitis or Crohn's disease, and that IL-38 acts to maintain homeostasis in the intestinal tract. Here we investigated the role of endogenous IL-38 in experimental colitis in mice deficient in IL-38 by deletion of exons 1-4 in C57 BL/6 mice. Compared to WT mice, IL-38 deficient mice subjected to dextran sulfate sodium (DSS) showed greater severity of disease, more weight loss, increased intestinal permeability, and a worse histological phenotype including increased neutrophil influx in the colon. Mice lacking IL-38 exhibited elevated colonic
Identifiants
pubmed: 35693797
doi: 10.3389/fimmu.2022.840719
pmc: PMC9181991
doi:
Substances chimiques
Cytokines
0
Il1f10 protein, mouse
0
Interleukin-1
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
RNA, Messenger
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
840719Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK122741
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI015614
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008497
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK120072
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK129410
Pays : United States
Informations de copyright
Copyright © 2022 de Graaf, Wang, Amo-Aparicio, Lee, Dowdell, Tengesdal, Marchetti, Colgan, Joosten and Dinarello.
Déclaration de conflit d'intérêts
LJ serves on Olatec’s scientific advisory board and receives compensation. CD serves as chairman of Olatec’s scientific advisory board, is co-chief scientific officer, receives compensation, and has equity in Olatec. CM serves as director for Olatec’s innovative science program and has equity in Olatec. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Clin Exp Immunol. 2016 May;184(2):159-73
pubmed: 26701127
Biomed Res Int. 2018 Dec 10;2018:5140691
pubmed: 30643810
Gut. 2010 Sep;59(9):1192-9
pubmed: 20442201
Clin Exp Immunol. 1998 Dec;114(3):385-91
pubmed: 9844047
Cytokine. 2020 Mar;127:154963
pubmed: 31927461
Proc Natl Acad Sci U S A. 2019 Dec 16;:
pubmed: 31843928
Gut. 2003 Jan;52(1):65-70
pubmed: 12477762
J Immunol. 2016 Jan 1;196(1):34-8
pubmed: 26590314
Nature. 2013 Nov 14;503(7475):272-6
pubmed: 24089213
J Allergy Clin Immunol. 2020 Jan;145(1):16-27
pubmed: 31910984
N Engl J Med. 2002 Aug 8;347(6):417-29
pubmed: 12167685
Eur J Immunol. 2021 Mar;51(3):662-671
pubmed: 33125159
Clin Colon Rectal Surg. 2018 May;31(3):168-178
pubmed: 29720903
Nat Immunol. 2019 May;20(5):527-533
pubmed: 30962589
Cytokine. 2021 Jan;137:155334
pubmed: 33128926
J Biol Chem. 2001 Jun 8;276(23):20597-602
pubmed: 11278614
F1000Res. 2016 Jun 22;5:
pubmed: 27508077
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3001-5
pubmed: 22315422
Cell Death Dis. 2018 Oct 30;9(11):1104
pubmed: 30377293
Ann N Y Acad Sci. 2022 Feb;1508(1):92-104
pubmed: 34671981
Immunity. 2007 Oct;27(4):549-59
pubmed: 17967410
Adv Sci (Weinh). 2022 Apr;9(10):e2103035
pubmed: 35119210
Biomolecules. 2019 Aug 05;9(8):
pubmed: 31387327
Life Sci. 2021 Apr 1;270:119123
pubmed: 33548287
Dig Dis Sci. 2022 Jul;67(7):2912-2921
pubmed: 34345943
Ann Med. 2007;39(3):177-99
pubmed: 17457716
Inflamm Res. 2014 Dec;63(12):979-85
pubmed: 25297810
Mucosal Immunol. 2016 Sep;9(5):1193-204
pubmed: 26813344
Int J Epidemiol. 2019 Jun 1;48(3):767-780
pubmed: 30476131
J Allergy Clin Immunol. 2021 Jan;147(1):267-279
pubmed: 32941940
Gut. 2004 Dec;53(12):1813-6
pubmed: 15542520
Cell. 2006 Feb 24;124(4):783-801
pubmed: 16497588
Inflamm Bowel Dis. 2016 Feb;22(2):303-14
pubmed: 26752465
J Leukoc Biol. 2021 Nov;110(5):907-915
pubmed: 33620105
Nat Genet. 2009 Jan;41(1):71-6
pubmed: 19098911
Cancer Immunol Immunother. 2020 Jan;69(1):69-79
pubmed: 31786620
Front Pharmacol. 2019 Jan 30;10:40
pubmed: 30761006
J Vis Exp. 2012 Feb 01;(60):
pubmed: 22331082
Ther Adv Chronic Dis. 2020 Feb 5;11:2040622319899297
pubmed: 32076497
Immunol Rev. 2017 Nov;280(1):57-73
pubmed: 29027223
Immunity. 2010 Mar 26;32(3):379-91
pubmed: 20303296
Cell Death Dis. 2019 Dec 2;10(12):906
pubmed: 31787755
Int J Mol Sci. 2020 Jun 13;21(12):
pubmed: 32545788
J Exp Med. 2012 Aug 27;209(9):1595-609
pubmed: 22891275
Immunity. 2008 Mar;28(3):285-7
pubmed: 18341998
Gut. 2014 Apr;63(4):598-609
pubmed: 23793223
Cell Rep. 2019 Apr 16;27(3):835-846.e5
pubmed: 30995480