The influence of maternal weight and alcohol exposure on infant physical characteristics and neurodevelopmental outcomes.
Dysmorphology
Fetal alcohol spectrum disorders
Growth
Infancy
Maternal weight
Neurodevelopment
Prenatal alcohol exposure
Journal
Current research in toxicology
ISSN: 2666-027X
Titre abrégé: Curr Res Toxicol
Pays: Netherlands
ID NLM: 101771915
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
12
2021
revised:
23
03
2022
accepted:
17
05
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Mothers of children with fetal alcohol spectrum disorders tend to have lower weight compared to other mothers. Yet how alcohol and maternal weight may predispose infants to poorer physical growth and neurodevelopmental trajectories is relatively unexplained. South African mothers ( Postpartum maternal weight was positively associated with birth length, weight, and head circumference centile, but the rate of growth from birth to nine months was similar among all infants. Maternal weight was inversely associated with dysmorphology. Many infants in this population were performing within the borderline or extremely low range. Higher maternal weight was associated with significantly better cognitive and motor performance at 6 weeks; however, the rate of developmental growth was similar among all infants, regardless of postpartum maternal weight. Higher postpartum maternal weight may be a protective factor but does not eliminate the adverse effects of alcohol on infant growth and dysmorphology. Regardless of maternal weight, alcohol remains a powerful teratogen and moderate to high use prenatally can result in adverse infant physical and neurocognitive development.
Sections du résumé
Background
UNASSIGNED
Mothers of children with fetal alcohol spectrum disorders tend to have lower weight compared to other mothers. Yet how alcohol and maternal weight may predispose infants to poorer physical growth and neurodevelopmental trajectories is relatively unexplained.
Methods
UNASSIGNED
South African mothers (
Results
UNASSIGNED
Postpartum maternal weight was positively associated with birth length, weight, and head circumference centile, but the rate of growth from birth to nine months was similar among all infants. Maternal weight was inversely associated with dysmorphology. Many infants in this population were performing within the borderline or extremely low range. Higher maternal weight was associated with significantly better cognitive and motor performance at 6 weeks; however, the rate of developmental growth was similar among all infants, regardless of postpartum maternal weight.
Conclusion
UNASSIGNED
Higher postpartum maternal weight may be a protective factor but does not eliminate the adverse effects of alcohol on infant growth and dysmorphology. Regardless of maternal weight, alcohol remains a powerful teratogen and moderate to high use prenatally can result in adverse infant physical and neurocognitive development.
Identifiants
pubmed: 35694418
doi: 10.1016/j.crtox.2022.100076
pii: S2666-027X(22)00013-5
pmc: PMC9178472
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100076Subventions
Organisme : NICHD NIH HHS
ID : P2C HD050924
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Am J Public Health. 2000 Dec;90(12):1905-12
pubmed: 11111264
J Pediatr. 2011 Feb;158(2):221-6
pubmed: 20863516
Pediatrics. 2015 Feb;135(2):264-70
pubmed: 25583914
Alcohol Res Health. 2011;34(1):15-26
pubmed: 23580036
Matern Child Health J. 2013 Dec;17(10):1872-8
pubmed: 23247668
Int J Environ Res Public Health. 2017 May 12;14(5):
pubmed: 28498341
JAMA. 2018 Feb 6;319(5):474-482
pubmed: 29411031
Drug Alcohol Depend. 2016 Feb 1;159:207-18
pubmed: 26774945
Alcohol Clin Exp Res. 2016 Jan;40(1):18-32
pubmed: 26727519
Int Sch Res Notices. 2017 Aug 1;2017:1631760
pubmed: 28835912
Nestle Nutr Inst Workshop Ser. 2014;78:111-20
pubmed: 24504211
Drug Alcohol Depend. 2016 Nov 01;168:274-286
pubmed: 27736681
Drug Alcohol Depend. 2007 May 11;88(2-3):259-71
pubmed: 17127017
J Stud Alcohol. 2002 Jan;63(1):6-17
pubmed: 11925060
Alcohol Clin Exp Res. 2013 Mar;37(3):452-62
pubmed: 23013325
J Stud Alcohol. 2005 Sep;66(5):593-604
pubmed: 16331845
Int J Epidemiol. 2014 Jun;43(3):783-92
pubmed: 24569381
Neuropsychol Rev. 2011 Jun;21(2):81-101
pubmed: 21503685
Alcohol Clin Exp Res. 2008 May;32(5):738-53
pubmed: 18336634
Acta Neuropsychiatr. 2020 Jan 06;:1-8
pubmed: 31902391
Reprod Toxicol. 2014 Jul;46:31-9
pubmed: 24568797
Pediatrics. 2005 Jan;115(1):39-47
pubmed: 15629980
Pediatrics. 2016 Aug;138(2):
pubmed: 27464676
J Dev Orig Health Dis. 2018 Dec;9(6):653-660
pubmed: 30103837
Wien Klin Wochenschr. 2020 Sep;132(17-18):535-541
pubmed: 32451818
Alcohol Alcohol. 2004 Nov-Dec;39(6):503-8
pubmed: 15351745
Pediatrics. 2019 Dec;144(6):
pubmed: 31744890
Alcohol Clin Exp Res. 2020 Jun;44(6):1245-1260
pubmed: 32173870
J Acquir Immune Defic Syndr. 2020 Dec 1;85(4):507-516
pubmed: 33136752
Am J Public Health. 2005 Jul;95(7):1190-9
pubmed: 15933241
Int J Epidemiol. 2017 Oct 1;46(5):1653-1666
pubmed: 29040611
Drug Alcohol Depend. 2013 Dec 1;133(2):502-12
pubmed: 23932841
Adv Nutr. 2019 Mar 1;10(2):196-204
pubmed: 30801614
Alcohol Clin Exp Res. 2004 Nov;28(11):1732-45
pubmed: 15547461
J Pediatr. 1987 Aug;111(2):267-8
pubmed: 3612403
Drug Alcohol Depend. 2021 Jan 1;218:108408
pubmed: 33250379
J Dev Behav Pediatr. 2004 Aug;25(4):228-38
pubmed: 15308923
Int J Obes (Lond). 2012 Oct;36(10):1312-9
pubmed: 22964791
Reprod Toxicol. 2016 Jan;59:101-8
pubmed: 26656914
Alcohol Clin Exp Res. 2021 Aug;45(8):1624-1638
pubmed: 34342019
Lancet Glob Health. 2017 Dec;5(12):e1249-e1257
pubmed: 29132614
PLoS One. 2012;7(8):e43067
pubmed: 22937012
MMWR Morb Mortal Wkly Rep. 2018 Jan 05;66(51-52):1402-1407
pubmed: 29300720
J Anal Toxicol. 1996 Sep;20(5):287-90
pubmed: 8872236
Pediatrics. 2016 Aug;138(2):
pubmed: 27401098
Am J Addict. 2011 Sep-Oct;20(5):468-75
pubmed: 21838847
Reprod Toxicol. 2016 Aug;63:13-21
pubmed: 27174445
Pediatrics. 1968 Jan;41(1):106-14
pubmed: 5635472
Alcohol Clin Exp Res. 2013 May;37(5):818-30
pubmed: 23241076