Diabetes Is the Strongest Predictor of Limited Exercise Capacity in Chronic Heart Failure and Preserved Ejection Fraction (HFpEF).
6-min walk test
Doppler echocardiography
diabetes mellitus
exercise capacity
heart failure
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
02
2022
accepted:
21
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Type 2 diabetes mellitus (T2DM) is a known risk factor in patients with heart failure (HF), but its impact on phenotypic presentations remains unclear. This study aimed to prospectively examine the relationship between T2DM and functional exercise capacity, assessed by the 6-min walk test (6-MWT) in chronic HF. We studied 344 chronic patients with HF (mean age 61 ± 10 years, 54% female) in whom clinical, biochemical, and anthropometric data were available and all patients underwent an echo-Doppler study and a 6-MWT on the same day. The 6-MWT distance divided the cohort into; Group I: those who managed ≤ 300 m and Group II: those who managed >300 m. Additionally, left ventricular (LV) ejection fraction (EF), estimated using the modified Simpson's method, classified patients into HF with preserved EF (HFpEF) and HF with reduced EF (HFrEF). The results showed that 111/344 (32%) patients had T2DM, who had a higher prevalence of arterial hypertension ( Predictors of exercise intolerance in patients with chronic HF differ according to LV systolic function, demonstrated as EF. T2DM seems the most powerful predictor of limited exercise capacity in patients with HFpEF.
Sections du résumé
Background and Aim
UNASSIGNED
Type 2 diabetes mellitus (T2DM) is a known risk factor in patients with heart failure (HF), but its impact on phenotypic presentations remains unclear. This study aimed to prospectively examine the relationship between T2DM and functional exercise capacity, assessed by the 6-min walk test (6-MWT) in chronic HF.
Methods
UNASSIGNED
We studied 344 chronic patients with HF (mean age 61 ± 10 years, 54% female) in whom clinical, biochemical, and anthropometric data were available and all patients underwent an echo-Doppler study and a 6-MWT on the same day. The 6-MWT distance divided the cohort into; Group I: those who managed ≤ 300 m and Group II: those who managed >300 m. Additionally, left ventricular (LV) ejection fraction (EF), estimated using the modified Simpson's method, classified patients into HF with preserved EF (HFpEF) and HF with reduced EF (HFrEF).
Results
UNASSIGNED
The results showed that 111/344 (32%) patients had T2DM, who had a higher prevalence of arterial hypertension (
Conclusion
UNASSIGNED
Predictors of exercise intolerance in patients with chronic HF differ according to LV systolic function, demonstrated as EF. T2DM seems the most powerful predictor of limited exercise capacity in patients with HFpEF.
Identifiants
pubmed: 35694665
doi: 10.3389/fcvm.2022.883615
pmc: PMC9178085
doi:
Types de publication
Journal Article
Langues
eng
Pagination
883615Informations de copyright
Copyright © 2022 Berisha-Muharremi, Henein, Dini, Haliti, Bytyçi, Ibrahimi, Poniku, Batalli, Tafarshiku, Elezi and Bajraktari.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt B):1211-1221
pubmed: 28412423
Neth Heart J. 2021 Jul;29(7-8):370-376
pubmed: 33439465
Can Med Assoc J. 1985 Apr 15;132(8):919-23
pubmed: 3978515
J Am Coll Cardiol. 2001 Aug;38(2):421-8
pubmed: 11499733
Circulation. 2003 Sep 2;108(9):1146-62
pubmed: 12952829
Eur J Heart Fail. 2006 Mar;8(2):198-202
pubmed: 16188496
N Engl J Med. 2006 Jul 20;355(3):251-9
pubmed: 16855265
Eur J Heart Fail. 2021 Mar;23(3):352-380
pubmed: 33605000
Eur J Echocardiogr. 2011 May;12(5):339-53
pubmed: 21555455
Diabetes. 2007 Jun;56(6):1592-9
pubmed: 17351150
J Am Soc Echocardiogr. 2002 Mar;15(3):275-90
pubmed: 11875394
Front Cardiovasc Med. 2022 Mar 23;9:816847
pubmed: 35402560
Cardiovasc Diabetol. 2020 Sep 19;19(1):142
pubmed: 32950064
Lancet. 2001 Aug 11;358(9280):439-44
pubmed: 11513906
Nutrition. 1989 Sep-Oct;5(5):303-11; discussion 312-3
pubmed: 2520314
J Am Heart Assoc. 2017 Oct 31;6(11):
pubmed: 29089342
Int J Cardiol Heart Vessel. 2014 Apr 24;4:203-207
pubmed: 29450190
Circ Heart Fail. 2014 Jan;7(1):123-30
pubmed: 24162898
J Am Coll Cardiol. 2005 Sep 6;46(5):930-1
pubmed: 16139146
Eur J Heart Fail. 2020 Mar;22(3):458-468
pubmed: 31950651
Adv Med Sci. 2018 Mar;63(1):30-35
pubmed: 28818746
Eur J Heart Fail. 2016 Mar;18(3):328-36
pubmed: 26693947
Eur J Heart Fail. 2004 Oct;6(6):687-91
pubmed: 15542403
Circulation. 1993 Jul;88(1):107-15
pubmed: 8319323
Int J Cardiol. 2011 Feb 3;146(3):385-9
pubmed: 19699003
Circ Res. 2021 May 14;128(10):1421-1434
pubmed: 33983838
Curr Heart Fail Rep. 2004 Dec;1(4):176-82
pubmed: 16036042
Front Cardiovasc Med. 2022 Feb 24;9:820178
pubmed: 35282383
Cardiovasc Ultrasound. 2017 Apr 26;15(1):12
pubmed: 28446199
J Am Coll Cardiol. 1988 Aug;12(2):426-40
pubmed: 3392336
Am J Cardiol. 2002 Jan 15;89(2):191-7
pubmed: 11792341
Echocardiography. 2019 Jun;36(6):1045-1053
pubmed: 31148237
Circulation. 1991 Mar;83(3):778-86
pubmed: 1999029
Eur Heart J Cardiovasc Imaging. 2015 Feb;16(2):217-24
pubmed: 25552469
J Am Soc Echocardiogr. 2017 Apr;30(4):303-371
pubmed: 28314623
Circ Heart Fail. 2014 Jul;7(4):580-9
pubmed: 24833648
Anatol J Cardiol. 2015 Jan;15(1):63-8
pubmed: 25550250
Circulation. 2022 Feb 22;145(8):e153-e639
pubmed: 35078371
Eur J Heart Fail. 2005 Aug;7(5):859-64
pubmed: 15923138
Cardiovasc Ultrasound. 2012 Sep 11;10(1):36
pubmed: 22966942
Cureus. 2021 Nov 9;13(11):e19398
pubmed: 34926000
N Engl J Med. 2016 Nov 10;375(19):1868-1877
pubmed: 27959663
Eur J Heart Fail. 2006 May;8(3):321-5
pubmed: 16266825
J Am Coll Cardiol. 2016 Feb 16;67(6):659-670
pubmed: 26868691
Eur Heart J. 2005 Sep;26(17):1742-51
pubmed: 15831556
J Am Soc Echocardiogr. 2015 Oct;28(10):1184-93
pubmed: 26232892
Acta Med Scand. 1988;224(6):557-62
pubmed: 3207068
Circ Res. 2019 Jan 4;124(1):121-141
pubmed: 30605420
J Chronic Dis. 1985;38(6):517-24
pubmed: 4008592
Diabetes Care. 2006 Apr;29(4):895-900
pubmed: 16567834