The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib.
AKT
PI3K
angiogenesis
endothelial cell
vascular malformations
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
07 07 2022
07 07 2022
Historique:
revised:
19
05
2022
received:
04
01
2022
accepted:
20
05
2022
pubmed:
14
6
2022
medline:
9
7
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Low-flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium, which result in overactivation of the PI3K/AKT pathway. Lack of robust in vivo preclinical data has prevented the development and translation into clinical trials of specific molecular therapies for these diseases. Here, we demonstrate that the Pik3ca
Identifiants
pubmed: 35695059
doi: 10.15252/emmm.202115619
pmc: PMC9260211
doi:
Substances chimiques
Aminopyridines
0
Imidazoles
0
Protein Kinase Inhibitors
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Miransertib
T1DQI1B52Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15619Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Nat Cancer. 2021 Jun;2(6):587-597
pubmed: 35118422
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Sci Rep. 2020 Nov 25;10(1):20560
pubmed: 33239692
Sci Transl Med. 2016 Mar 30;8(332):332ra43
pubmed: 27030595
Nat Commun. 2020 Jun 8;11(1):2869
pubmed: 32513927
Am J Med Genet A. 2019 Jul;179(7):1319-1324
pubmed: 31058421
Arterioscler Thromb Vasc Biol. 2018 May;38(5):1216-1229
pubmed: 29449337
Orphanet J Rare Dis. 2021 Feb 27;16(1):109
pubmed: 33639990
J Pathol. 2016 Dec;240(4):387-396
pubmed: 27577520
Am J Med Genet A. 2015 Feb;167A(2):287-95
pubmed: 25557259
Nat Med. 2005 Nov;11(11):1188-96
pubmed: 16227992
Nat Commun. 2016 Nov 29;7:13650
pubmed: 27897192
Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2232-6
pubmed: 25082229
Genesis. 2008 Feb;46(2):74-80
pubmed: 18257043
Nat Protoc. 2010 Sep;5(9):1518-34
pubmed: 20725067
Clin Cancer Res. 2016 Jun 1;22(11):2599-601
pubmed: 26979397
Am J Clin Dermatol. 2020 Oct;21(5):657-668
pubmed: 32557381
Nature. 2021 Jan;589(7842):437-441
pubmed: 33299176
Circulation. 2018 Nov 20;138(21):2379-2394
pubmed: 29976569
Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534
pubmed: 31110302
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Orphanet J Rare Dis. 2021 Jul 8;16(1):306
pubmed: 34238334
Nature. 2008 May 29;453(7195):662-6
pubmed: 18449193
N Engl J Med. 2021 Sep 9;385(11):996-1004
pubmed: 34496175
Circ Res. 2021 Jun 25;129(1):136-154
pubmed: 34166072
Genome Biol. 2014;15(12):550
pubmed: 25516281
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Bioinformatics. 2016 Jan 15;32(2):292-4
pubmed: 26428292
J Clin Invest. 2005 Aug;115(8):2119-27
pubmed: 16075056
Cold Spring Harb Mol Case Stud. 2020 Feb 3;6(1):
pubmed: 32014856
Angiogenesis. 2020 Aug;23(3):425-442
pubmed: 32350708
Vasc Biol. 2019 Nov 29;1(1):H125-H134
pubmed: 32923964
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Pediatr Blood Cancer. 2019 Aug;66(8):e27790
pubmed: 31045327
Nat Commun. 2016 Mar 14;7:10960
pubmed: 26971877
J Clin Invest. 2012 Feb;122(2):553-7
pubmed: 22214849
Cell Rep. 2015 Mar 17;10(10):1708-1721
pubmed: 25772358
Sci Rep. 2015 Dec 11;5:17162
pubmed: 26657992
Anticancer Drugs. 2017 Jun;28(5):503-513
pubmed: 28240679
Sci Rep. 2019 Aug 26;9(1):12352
pubmed: 31451744
Elife. 2020 Nov 03;9:
pubmed: 33138917
Exp Cell Res. 2013 May 15;319(9):1348-55
pubmed: 23500680
Genesis. 2007 Sep;45(9):593-605
pubmed: 17868096
Science. 2004 Apr 23;304(5670):554
pubmed: 15016963
J Clin Invest. 2005 Sep;115(9):2382-92
pubmed: 16100571
Nat Genet. 2009 Jan;41(1):118-24
pubmed: 19079259
Nucleic Acids Res. 2019 May 7;47(8):e47
pubmed: 30783653
PLoS One. 2015 Oct 15;10(10):e0140479
pubmed: 26469692
EMBO Mol Med. 2022 Jul 7;14(7):e15619
pubmed: 35695059
Curr Opin Hematol. 2019 May;26(3):170-178
pubmed: 30855339
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Vasc Med. 2020 Aug;25(4):364-377
pubmed: 32568624
J Pediatr. 2015 Apr;166(4):1048-54.e1-5
pubmed: 25681199
Nat Rev Drug Discov. 2021 Oct;20(10):741-769
pubmed: 34127844
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Nat Rev Cancer. 2020 Jul;20(7):383-397
pubmed: 32341551
Development. 2013 Jul;140(14):3051-61
pubmed: 23785053
Nat Commun. 2017 Dec 15;8(1):2149
pubmed: 29247167
Sci Transl Med. 2016 Mar 30;8(332):332ra42
pubmed: 27030594
Nature. 2018 Jun;558(7711):540-546
pubmed: 29899452
Am J Hum Genet. 2015 Dec 3;97(6):914-21
pubmed: 26637981
Nature. 2021 Jun;594(7862):271-276
pubmed: 33910229
Angiogenesis. 2015 Apr;18(2):151-62
pubmed: 25424831
Brief Bioinform. 2013 Mar;14(2):178-92
pubmed: 22517427