Clopidogrel Resistance Among Ischemic Stroke Patients and Its Risk Factors in Indonesia.
Clopidogrel Resistance
Ischemic Stroke
Risk Factors
Journal
Acta medica academica
ISSN: 1840-2879
Titre abrégé: Acta Med Acad
Pays: Bosnia and Herzegovina
ID NLM: 101587903
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
05
01
2022
accepted:
25
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
15
6
2022
Statut:
ppublish
Résumé
Clopidogrel is a common antiplatelet used as secondary prevention of ischemic stroke, known to have better efficacy than aspirin, with a equivalent safety profile. However, clopidogrel resistance is not uncommon but has not been widely studied in Asia. This study will further assess clopidogrel resistance and its risk factors. A cross-sectional study was conducted at Rumah Sakit Universitas, Indonesia, and Rumah Sakit Cipto Mangunkusumo, Indonesia in 2020-2021. All patients had had at least one episode of ischemic stroke. Clopidogrel resistance was assessed using a VerifyNow assay. 57 subjects were enrolled in this study. We found 15.8% of subjects were clopidogrel resistant. Gender was significantly associated with clopidogrel resistance, with males having 80% lower clopidogrel resistance (OR 0.2 (95% CI 0.022 - 0.638); P=0.006). Meanwhile, smoking was not associated with clopidogrel responsiveness (P=0.051). We found no association between haemoglobin, blood glucose, HbA1c, cholesterol, liver enzymes, serum urea concentration or creatinine levels and clopidogrel resistance. Clopidogrel remains an effective treatment to prevent recurrent ischemic stroke in Indonesia. Further studies are needed to assess gene polymorphism and clopidogrel resistance, which may explain the findings of this study.
Identifiants
pubmed: 35695400
pii: ama2006-124.367
doi: 10.5644/ama2006-124.367
pmc: PMC9982849
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Clopidogrel
A74586SNO7
Ticlopidine
OM90ZUW7M1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-34Informations de copyright
Copyright © 2022 by Academy of Sciences and Arts of Bosnia and Herzegovina.
Références
N Engl J Med. 2013 Jul 4;369(1):11-9
pubmed: 23803136
Expert Rev Neurother. 2011 Feb;11(2):251-63
pubmed: 21306212
Caspian J Intern Med. 2020;11(2):124-134
pubmed: 32509239
J Stroke Cerebrovasc Dis. 2011 May-Jun;20(3):227-30
pubmed: 20621513
Lancet. 1996 Nov 16;348(9038):1329-39
pubmed: 8918275
Intern Med. 2011;50(1):31-5
pubmed: 21212570
Stroke. 2021 Jul;52(7):e364-e467
pubmed: 34024117
Intern Med. 2014;53(22):2575-9
pubmed: 25400177
Eur Heart J. 2009 Aug;30(16):1964-77
pubmed: 19633016
Ann Indian Acad Neurol. 2019 Apr-Jun;22(2):147-152
pubmed: 31007424