The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice.
diet
early-life stress
gut-brain axis
interventions
microbiome
microbiota
polyunsaturated fatty acids
Journal
mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
14
6
2022
medline:
14
6
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Early-life stress (ELS) leads to increased vulnerability for mental and metabolic disorders. We have previously shown that a low dietary ω-6/ω-3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-induced cognitive impairments. Due to the importance of the gut microbiota as a determinant of long-term health, we here study the impact of ELS and dietary PUFAs on the gut microbiota and how this relates to the previously described cognitive, metabolic, and fatty acid profiles. Male mice were exposed to ELS via the limited bedding and nesting paradigm (postnatal day (P)2 to P9 and to an early diet (P2 to P42) with an either high (15) or low (1) ω-6 linoleic acid to ω-3 alpha-linolenic acid ratio. 16S rRNA was sequenced and analyzed from fecal samples at P21, P42, and P180. Age impacted α- and β-diversity. ELS and diet together predicted variance in microbiota composition and affected the relative abundance of bacterial groups at several taxonomic levels in the short and long term. For example, age increased the abundance of the phyla
Identifiants
pubmed: 35695433
doi: 10.1128/msystems.00180-22
pmc: PMC9238388
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Omega-3
0
Fatty Acids, Unsaturated
0
RNA, Ribosomal, 16S
0
Banques de données
figshare
['10.6084/m9.figshare.16748824']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e0018022Références
Nat Commun. 2020 Jul 3;11(1):3285
pubmed: 32620774
Psychopharmacology (Berl). 2021 Jan;238(1):149-163
pubmed: 32951067
J Neurogastroenterol Motil. 2017 Jan 30;23(1):135-143
pubmed: 27829577
Gut. 2001 Feb;48(2):198-205
pubmed: 11156640
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
Science. 2013 Feb 1;339(6119):548-54
pubmed: 23363771
FEMS Microbiol Ecol. 2011 Aug;77(2):404-12
pubmed: 21539582
Evol Bioinform Online. 2007 Feb 17;2:121-8
pubmed: 19455206
Neurosci Biobehav Rev. 2017 Dec;83:458-471
pubmed: 28918360
Sci Rep. 2016 Dec 06;6:38481
pubmed: 27922089
Nucleic Acids Res. 2016 Jul 8;44(W1):W242-5
pubmed: 27095192
Front Microbiol. 2016 Jun 28;7:979
pubmed: 27446020
Adv Nutr. 2013 Jan 01;4(1):16-28
pubmed: 23319119
PLoS One. 2015 Oct 01;10(10):e0139721
pubmed: 26426902
Gut Microbes. 2017 Sep 3;8(5):428-439
pubmed: 28586297
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Stand Genomic Sci. 2011 Apr 29;4(2):200-9
pubmed: 21677857
J Nutr. 1993 Nov;123(11):1939-51
pubmed: 8229312
Nutr J. 2014 Nov 22;13:107
pubmed: 25416917
Pediatr Allergy Immunol. 2014 Aug;25(5):428-38
pubmed: 24899389
Psychoneuroendocrinology. 2017 Dec;86:73-77
pubmed: 28917185
Nutr Rev. 2015 Jun;73(6):376-85
pubmed: 26011912
Biol Psychiatry. 2019 Jan 15;85(2):150-163
pubmed: 30064690
Brain Behav Immun. 2017 Oct;65:20-32
pubmed: 28179108
Transl Psychiatry. 2018 Jan 10;8(1):6
pubmed: 29317592
Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G168-75
pubmed: 21940902
Gut. 2018 Nov;67(11):1974-1983
pubmed: 28951525
Microbiome. 2020 Feb 11;8(1):15
pubmed: 32046785
Tohoku J Exp Med. 2016;240(1):31-7
pubmed: 27558477
Stress. 2017 Sep;20(5):421-448
pubmed: 28617197
Dis Model Mech. 2015 Jan;8(1):1-16
pubmed: 25561744
Mol Ecol Resour. 2017 Nov;17(6):e122-e132
pubmed: 28695665
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
ISME J. 2012 Aug;6(8):1621-4
pubmed: 22402401
Nat Med. 2016 Jul 7;22(7):713-22
pubmed: 27387886
Gastroenterol Clin North Am. 2019 Sep;48(3):389-405
pubmed: 31383278
Cell Metab. 2008 Apr;7(4):277
pubmed: 18396128
Cell Rep. 2021 Sep 28;36(13):109765
pubmed: 34592155
Psychopharmacology (Berl). 2019 May;236(5):1583-1596
pubmed: 31147734
Genome Res. 2011 Mar;21(3):494-504
pubmed: 21212162
Mol Neurobiol. 2011 Oct;44(2):203-15
pubmed: 21279554
mSphere. 2018 Jul 18;3(4):
pubmed: 30021874
Nat Rev Microbiol. 2012 Nov;10(11):735-42
pubmed: 23000955
J Med Microbiol. 2020 Nov;69(11):1293-1302
pubmed: 32965212
World J Mens Health. 2020 Jan;38(1):48-60
pubmed: 30929328
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Front Microbiol. 2019 Jun 21;10:1397
pubmed: 31316481
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Mol Metab. 2018 Sep;15:8-19
pubmed: 29773464
PLoS One. 2016 May 05;11(5):e0155037
pubmed: 27149676
Int J Mol Sci. 2017 Dec 07;18(12):
pubmed: 29215589
Clin Gastroenterol Hepatol. 2012 Apr;10(4):385-90.e1-3
pubmed: 22178460
BMJ. 2020 Oct 28;371:m3048
pubmed: 33115717
Front Behav Neurosci. 2019 Jun 04;13:123
pubmed: 31231198
Am J Clin Nutr. 2011 May;93(5):950-62
pubmed: 21367944
Sci Rep. 2017 Aug 25;7(1):9523
pubmed: 28842640
Gastroenterology. 2009 Nov;137(5):1716-24.e1-2
pubmed: 19706296
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Arch Pediatr Adolesc Med. 2010 Jun;164(6):540-6
pubmed: 20530304
Nucleic Acids Res. 2007;35(21):7188-96
pubmed: 17947321
Psychoneuroendocrinology. 2015 Aug;58:79-90
pubmed: 25965872
Psychoneuroendocrinology. 2017 Mar;77:186-195
pubmed: 28088658
Psychopharmacology (Berl). 2011 Mar;214(1):71-88
pubmed: 20886335
Genome Biol. 2013 Jan 24;14(1):R4
pubmed: 23347395
Dev Psychobiol. 1999 Sep;35(2):146-55
pubmed: 10461128
Curr Opin Neurobiol. 2020 Jun;62:76-82
pubmed: 31972462
Endocrinology. 2008 Oct;149(10):4892-900
pubmed: 18566122
Science. 2011 Oct 7;334(6052):105-8
pubmed: 21885731
J Appl Microbiol. 2005;98(6):1303-15
pubmed: 15916644
Arch Med Res. 2014 Apr;45(3):195-202
pubmed: 24681186
Proc Nutr Soc. 2020 Feb;79(1):113-132
pubmed: 31250784
J Clin Invest. 2019 Oct 1;129(10):4050-4057
pubmed: 31573550
NPJ Sci Food. 2017 Dec 6;1:7
pubmed: 31304249
Lipids Health Dis. 2016 Apr 18;15:78
pubmed: 27090218
J Gastroenterol Hepatol. 2019 Aug;34(8):1368-1376
pubmed: 30402954
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Pediatr Res. 2007 Sep;62(3):240-5
pubmed: 17622962
Sci Rep. 2017 Mar 07;7:44182
pubmed: 28266645
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
pubmed: 20679230
Nature. 2012 Sep 13;489(7415):220-30
pubmed: 22972295
NPJ Biofilms Microbiomes. 2021 Mar 19;7(1):28
pubmed: 33741982
Hippocampus. 2015 Mar;25(3):309-28
pubmed: 25269685
Trends Mol Med. 2014 Sep;20(9):509-18
pubmed: 24956966
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Nat Microbiol. 2019 Apr;4(4):623-632
pubmed: 30718848
Neuron. 2016 Mar 2;89(5):892-909
pubmed: 26938439
BMC Biol. 2019 Oct 28;17(1):83
pubmed: 31660948
Gastroenterology. 2011 Aug;141(2):599-609, 609.e1-3
pubmed: 21683077
Physiol Rev. 2019 Oct 1;99(4):1877-2013
pubmed: 31460832
Brain Behav Immun. 2017 Jan;59:21-37
pubmed: 27423492
PLoS One. 2010 Mar 10;5(3):e9490
pubmed: 20224823
Brain Behav Immun. 2019 Aug;80:179-192
pubmed: 30872090
Nucleic Acids Res. 2009 Jan;37(Database issue):D141-5
pubmed: 19004872
Mol Neurodegener. 2014 Sep 13;9:36
pubmed: 25217888
Gut. 2000 Dec;47(6):861-9
pubmed: 11076888
J Nutr Biochem. 2015 Jan;26(1):24-35
pubmed: 25444517
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Nat Commun. 2018 Jul 18;9(1):2802
pubmed: 30022049
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9644-9651
pubmed: 31010921
Neurosci Biobehav Rev. 2018 Dec;95:191-201
pubmed: 30195933
Nat Commun. 2015 Jul 28;6:7735
pubmed: 26218677
J Child Psychol Psychiatry. 2008 Oct;49(10):1079-88
pubmed: 19017024
Diabetes Obes Metab. 2018 Jun;20(6):1408-1418
pubmed: 29460474
Transl Res. 2017 Jan;179:223-244
pubmed: 27832936
Mol Neurobiol. 2015 Aug;52(1):734-40
pubmed: 25284351
Biol Psychiatry. 2009 Feb 1;65(3):263-7
pubmed: 18723164
Int J Obes (Lond). 2018 Jul;42(7):1354-1365
pubmed: 29535450
FASEB J. 2019 Apr;33(4):5729-5740
pubmed: 30673509
Front Behav Neurosci. 2019 Aug 07;13:181
pubmed: 31440147