Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
30 Jun 2022
30 Jun 2022
Historique:
pubmed:
14
6
2022
medline:
2
7
2022
entrez:
13
6
2022
Statut:
epublish
Résumé
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Identifiants
pubmed: 35695483
doi: 10.1039/d2cc02278h
pmc: PMC9244874
doi:
Substances chimiques
Fatty Acids, Nonesterified
0
Serum Albumin
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7384-7387Références
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