Circulating Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Painful Temporomandibular Disorder and Low Back Pain.
Epidemiology
idiopathic pain
lipidomics
omega-6/omega-3 long-chain PUFA ratio
pain intensity
Journal
The journal of pain
ISSN: 1528-8447
Titre abrégé: J Pain
Pays: United States
ID NLM: 100898657
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
10
01
2022
revised:
03
05
2022
accepted:
25
05
2022
pubmed:
14
6
2022
medline:
12
10
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Preclinical studies demonstrate opposing effects of long-chain polyunsaturated fatty acid (PUFA) metabolites on inflammation and nociception. Omega-6 (n-6) PUFAs amplify both processes while omega-3 (n-3) PUFAs inhibit them. This cross-sectional study examined relationships between PUFAs in circulating erythrocytes and 2 chronic idiopathic pain conditions: temporomandibular disorder (TMD) and low back pain in a community-based sample of 503 U.S. adults. Presence or absence of TMD and low back pain, respectively, were determined by clinical examination and by responses to established screening questions. Liquid chromatography-tandem mass spectrometry quantified PUFAs. In multivariable logistic regression models, a higher ratio of n-6/n-3 long-chain PUFAs was associated with greater odds of TMD (odds ratio ((OR) = 1.75, 95% confidence limits (CL): 1.16, 2.64) and low back pain (OR = 1.63, 95% CL: 1.07, 2.49). Higher levels of the pronociceptive n-6 long-chain arachidonic acid (AA) were associated with a greater probability of both pain conditions for women, but not men. Higher levels of the antinociceptive long-chain n-3 PUFAs eicosapentaenoic and docosahexaenoic acids were associated with a lower probability of both pain conditions for men, but not women. As systemic inflammation is not a hallmark of these conditions, PUFAs may influence idiopathic pain through other mechanisms. PERSPECTIVE: This cross-sectional clinical study found that a higher ratio of circulating n-6/n-3 long-chain PUFAs was associated with greater odds of 2 common chronic overlapping pain conditions. This suggests that the pro and antinociceptive properties of n-6 and n-3 PUFAs, respectively, influence pain independently of their well-established inflammatory pathways.
Identifiants
pubmed: 35697285
pii: S1526-5900(22)00335-2
doi: 10.1016/j.jpain.2022.05.008
pmc: PMC9561056
mid: NIHMS1815304
pii:
doi:
Substances chimiques
Analgesics
0
Arachidonic Acids
0
Fatty Acids, Omega-3
0
Fatty Acids, Omega-6
0
Fatty Acids, Unsaturated
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1724-1736Subventions
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE029746
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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