Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State.

Adenosine Triphosphate / metabolism Adenylate Kinase / metabolism Alkaline Phosphatase / metabolism Humans Polyphosphates / metabolism Wound Healing
Angiogenesis Calcium ions Cell migration Compressed collagen Extracellular matrix Human epidermal keratinocytes Inorganic polyphosphate Nanoparticles Wound healing Zinc ions

Journal

Progress in molecular and subcellular biology
ISSN: 0079-6484
Titre abrégé: Prog Mol Subcell Biol
Pays: United States
ID NLM: 0233223

Informations de publication

Date de publication:
2022
Historique:
entrez: 13 6 2022
pubmed: 14 6 2022
medline: 16 6 2022
Statut: ppublish

Résumé

Many pathological conditions are characterized by a deficiency of metabolic energy. A prominent example is nonhealing or difficult-to-heal chronic wounds. Because of their unique ability to serve as a source of metabolic energy, inorganic polyphosphates (polyP) offer the opportunity to develop novel strategies to treat such wounds. The basis is the generation of ATP from the polymer through the joint action of two extracellular or plasma membrane-bound enzymes alkaline phosphatase and adenylate kinase, which enable the transfer of energy-rich phosphate from polyP to AMP with the formation of ADP and finally ATP. Building on these findings, it was possible to develop novel regeneratively active materials for wound therapy, which have already been successfully evaluated in first studies on patients.

Identifiants

DOI: 10.1007/978-3-031-01237-2_4 PMID: 35697937
pubmed: 35697937
doi: 10.1007/978-3-031-01237-2_4
doi:

Substances chimiques

Polyphosphates 0
Adenosine Triphosphate 8L70Q75FXE
Adenylate Kinase EC 2.7.4.3
Alkaline Phosphatase EC 3.1.3.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

51-82

Informations de copyright

© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Xiaohong Wang (X)

ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Hadrian Schepler (H)

Department of Dermatology, University Clinic Mainz, Mainz, Germany.

Meik Neufurth (M)

ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Shunfeng Wang (S)

ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Heinz C Schröder (HC)

ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Werner E G Müller (WEG)

ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. wmueller@uni-mainz.de.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Polyphosphate in Chronic Wound Healing:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Adenylate kinase › Polyphosphate in Chronic Wound Healing:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphatase alcaline › Polyphosphate in Chronic Wound Healing:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polyphosphate in Chronic Wound Healing:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Polyphosphates › Polyphosphate in Chronic Wound Healing:...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Polyphosphate in Chronic Wound Healing:...