Effects of Polyphosphate on Leukocyte Function.
Polyphosphate
leukocytes
platelets
Journal
Progress in molecular and subcellular biology
ISSN: 0079-6484
Titre abrégé: Prog Mol Subcell Biol
Pays: United States
ID NLM: 0233223
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
16
6
2022
Statut:
ppublish
Résumé
Leukocytes are immune cells derived from hematopoietic stem cells of the bone marrow which play essential roles in inflammatory and immune responses. In contrast to anucleate platelets and erythrocytes, leukocytes are differentiated from other blood cells by the presence of a nucleus, and consist of monocytes, neutrophils, lymphocytes, basophils, and eosinophils. Factors released from platelets mediate immune responses in part by recruitment and regulation of leukocyte activity. Platelet dense granules contain the highly anionic polymer polyphosphate (polyP) with monomer chain lengths of approximately 60-100 phosphates long, which are released into the microenvironment upon platelet activation. Recent studies suggest that polyP released from platelets plays roles in leukocyte migration, recruitment, accumulation, differentiation, and activation. Furthermore, bacterial-derived polyphosphate, generally consisting of phosphate monomer lengths in the hundreds to thousands, appear to play a role in pathogenic evasion of the host immune response. This review will discuss the effects of host and pathogenic-derived polyphosphate on leukocyte function.
Identifiants
pubmed: 35697939
doi: 10.1007/978-3-031-01237-2_6
doi:
Substances chimiques
Polyphosphates
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-143Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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