Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study.
COVID-19
SARS-CoV-2
Severity
Variant of concern Alpha
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
13 Jun 2022
13 Jun 2022
Historique:
received:
30
08
2021
accepted:
25
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
16
6
2022
Statut:
epublish
Résumé
The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease. We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]). Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.
Sections du résumé
BACKGROUND
BACKGROUND
The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.
METHODS
METHODS
We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.
RESULTS
RESULTS
We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]).
CONCLUSION
CONCLUSIONS
Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.
Identifiants
pubmed: 35698029
doi: 10.1186/s12879-022-07508-x
pii: 10.1186/s12879-022-07508-x
pmc: PMC9189443
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
540Investigateurs
Guillaume Martin-Blondel
(G)
Pierre Delobel
(P)
Gaspard Grouteau
(G)
Jean Roch Le Henaff
(JR)
Vincent Mear
(V)
Sandra Lagarrigues
(S)
Alais Frelat
(A)
Thomas De Nadai
(T)
Zara Steinmeyer
(Z)
Arnaud Del Bello
(A)
Stéphanie Ruiz
(S)
Benjamine Sarton
(B)
Elise Noel-Savina
(E)
Jacques Izopet
(J)
Nathan Peiffer-Smadja
(N)
Michael Thy
(M)
Mathilde Gare
(M)
Diane Le Pluart
(D)
François-Xavier Lescure
(FX)
Christophe Rioux
(C)
Laurène Deconinck
(L)
Yazdan Yazdanpanah
(Y)
None BenoitVisseaux
Diane Descamps
(D)
Charlotte Charpentier
(C)
Jean-Marc Chapplain
(JM)
Pierre Tattevin
(P)
Thomas Perpoint
(T)
Maude Bouscambert-Duchamp
(M)
Hodane Yonis
(H)
Paul Chabert
(P)
Hugues Cordel
(H)
Youssouf Mohamed-Kassim
(Y)
Nolan Hassold
(N)
Segolène Brichler
(S)
Julien Caliez
(J)
Thomas Rambaud
(T)
Marilucy Lopez-Sublet
(M)
Frédéric Adnet
(F)
Gilles Pialoux
(G)
Christia Palacios
(C)
Marwa Bachir
(M)
Marine Nadal
(M)
Mathieu Turpin
(M)
Antoine Parrot
(A)
Djeneba Fofana
(D)
Jérome Pacanowski
(J)
Karine Lacombe
(K)
Emmanuelle Gras
(E)
Laura Levi
(L)
Laure Surgers
(L)
Ines Devred
(I)
Nadia Valin
(N)
Thibault Chiarabini
(T)
Jean Luc Meynard
(JL)
Adeline Bauvois
(A)
Clara Duran
(C)
Elyanne Gault
(E)
Jean-Emmanuel Kahn
(JE)
Elisabeth Rouveix
(E)
Guillaume Geri
(G)
Didier Laureillard
(D)
Albert Sotto
(A)
Paul Loubet
(P)
Claire Roger
(C)
Julien Poissy
(J)
Marc Lambert
(M)
Ady Assaf
(A)
Laurence Bocket
(L)
Firouzé Bani-Sadr
(F)
Yohan N'Guyen
(Y)
Juliette Romaru
(J)
Maxime Hentzien
(M)
Thomas Gabas
(T)
Amélie Chabrol
(A)
Cecilia Billiou
(C)
Philippe Menager
(P)
Christophe Billy
(C)
Jean-Jacques Laurichesse
(JJ)
Fabrice Ketty N Simba
(FKN)
Pauline Caraux Paz
(PC)
Liliane Tinang
(L)
Agathe Bounhiol
(A)
Catherine Burnat
(C)
Sandrine Soriot-Thomas
(S)
Damien Basille
(D)
Jean Philippe Lanoix
(JP)
Yoan Zerbib
(Y)
Yoann Zerbib
(Y)
Anne Pouvaret
(A)
Fanny Lanternier
(F)
Helene Mascitti
(H)
Aurélien Dinh
(A)
Benjamin Davido
(B)
Philippe Lesprit
(P)
None Suresnes
None France
Service de Biologie Clinique Philippe Lesprit
(S)
Eric Farfour
(E)
Mathilde Neuville
(M)
Linda Nait Allaoua
(LN)
Michèle Lejaille
(M)
Nathalie De Castro
(N)
Jean-Michel Molina
(JM)
Diane Ponscarme
(D)
Mariagrazia Tateo
(M)
Geoffroy Liegeon
(G)
Ines Boussen
(I)
Pauline Huriez
(P)
André Cabié
(A)
Valentine Campana
(V)
Isabelle Calmont
(I)
Jean-Marie Turmel
(JM)
Guitteaud Karine
(G)
Pierre-François Sandrine
(PF)
Athéna Marquise
(A)
Ornella Cabras
(O)
Mélanie Lehoux
(M)
Cyrille Chabartier
(C)
Vincent Dubee
(V)
Diama Ndiaye
(D)
Caroline Lefeuvre
(C)
Achille Kouatchet
(A)
Duc Nguyen
(D)
Camille Tumiotto
(C)
Pierre Sioniac
(P)
Alexandre Boyer
(A)
Jean-François Faucher
(JF)
Edouard Desvaux
(E)
Sylvie Rogez
(S)
Paul Le Turnier
(P)
François Raffi
(F)
Emmanuel Canet
(E)
Antoine Roquilly
(A)
Louise Castain
(L)
Solène Secher
(S)
Véronique Mondain
(V)
Lionel Piroth
(L)
Christelle Auvray
(C)
Pascal Chavanet
(P)
Marielle Buisson
(M)
Sophie Mahy
(S)
François-Xavier Catherine
(FX)
Clementine Esteve
(C)
Michel Duong
(M)
Carole Charles
(C)
Sandrine Gohier
(S)
Céline Schaffer
(C)
Olivier Robineau
(O)
Perrine Bortolotti
(P)
Maxime Pradier
(M)
Francois Goehringer
(F)
Alice Corbel
(A)
Jeanne Kotzyba
(J)
Kévin Alexandre
(K)
Gaetan Beduneau
(G)
Elodie Alessandri-Gradt
(E)
Martin Martinot
(M)
Simon Gravier
(S)
Ciprian Ion
(C)
Victoire de Lastours
(V)
Roza Rahli
(R)
Valérie Garrait
(V)
Laurent Richier
(L)
Mounira Smati-Lafarge
(M)
Guillemette Frémont
(G)
Pierre Louis Nivose
(PL)
Marie Hélène André
(MH)
Magdalena Gerin
(M)
Aicha Hamdi
(A)
Naomi Sayre
(N)
Stephanie Cossec
(S)
Sophie Alviset
(S)
Pierre Alain Billy
(PA)
Marie Gousseff
(M)
Emmanuel Forestier
(E)
Anne-Laure Destrem
(AL)
Olivier Rogeaux
(O)
Alexie Bosch
(A)
Sabrina Bryant
(S)
Gaëlle Bourgeois
(G)
Ophélie Dos Santos Schaller
(O)
Marie-Christine Carret
(MC)
Nicolas Ettahar
(N)
Haciba Moudjahed
(H)
Nathalie Leone
(N)
Mehdi Djennaoui
(M)
Nicolas Lefebvre
(N)
Axel Ursenbach
(A)
François Danion
(F)
Yvon Ruch
(Y)
Morgane Solis
(M)
Hamid Merdji
(H)
Loïc Kassègne
(L)
Fanny Pommeret
(F)
Emeline Colomba Blameble
(EC)
Merad Manssouria
(M)
Annabelle Stoclin
(A)
Franck Griscelli
(F)
Sophie Deriaz
(S)
Eric Oziol
(E)
Laurent Favier
(L)
Julien Obiols
(J)
Pascal Gicquel
(P)
Christophe Rapp
(C)
Laurence Louvet
(L)
Paul Ihout
(P)
Jean-Benoit Zabbé
(JB)
Laurent Bellec
(L)
Tomasz Chroboczek
(T)
Sandrine Mégessier
(S)
Marie Lacoste
(M)
Benjamin Viala
(B)
Thibaut Challan-Belval
(T)
Chloé Wackenheim
(C)
Paule Letertre-Gibert
(P)
Olivier Grossi
(O)
Informations de copyright
© 2022. The Author(s).
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