Fibrosis Predictive Score in Caucasian Patients with Metabolic Syndrome.
liver elastography
liver fibrosis
liver steatosis
metabolic syndrome
Journal
Diabetes, metabolic syndrome and obesity : targets and therapy
ISSN: 1178-7007
Titre abrégé: Diabetes Metab Syndr Obes
Pays: New Zealand
ID NLM: 101515585
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
01
2022
accepted:
17
05
2022
entrez:
14
6
2022
pubmed:
15
6
2022
medline:
15
6
2022
Statut:
epublish
Résumé
Many of the patients presenting with metabolic syndrome (MetS) also have liver steatosis (NAFLD) and some of them could develop liver fibrosis. To develop a simple score that could rule out fibrosis, especially significant fibrosis (F≥2) and could be used in daily practice in patients with MetS, in order to identify patients at risk. A total of 204 patients with MetS were prospectively enrolled. Evaluation of liver fibrosis was made using Vibration Controlled Transient Elastography while evaluation of steatosis was achieved using ultrasound (US). Out of 204 patients with MetS, 179 patients (87.7%) had reliable liver stiffness measurements and 22.9% (41/179) had F ≥2. To formulate the fibrosis predicting score, all clinical variables associated with F ≥2 in the univariate analysis were considered in a multivariate regression model. According to the power of correlation, by consensus, we attributed 1 point for BMI >31.4 kg/m At an optimal cut-off value of <3.5, our score could be used to rule-out the risk for developing at least significant fibrosis with a high negative predictive value (NPV 89.2%) in patients with MetS.
Identifiants
pubmed: 35698652
doi: 10.2147/DMSO.S358744
pii: 358744
pmc: PMC9188395
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1703-1713Informations de copyright
© 2022 Mare et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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