Indoor Radon Exposure and COPD, Synergic Association? A Multicentric, Hospital-Based Case-Control Study in a Radon-Prone Area.
COPD
Case–control-studies
EPOC
España
Estudios de casos y controles
Fumar
Radón residencial
Residential radon
Smoking
Spain
Journal
Archivos de bronconeumologia
ISSN: 1579-2129
Titre abrégé: Arch Bronconeumol
Pays: Spain
ID NLM: 0354720
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
01
10
2020
accepted:
23
11
2020
entrez:
14
6
2022
pubmed:
15
6
2022
medline:
16
6
2022
Statut:
ppublish
Résumé
COPD is a multifactorial disease which causes considerable mortality and morbidity worldwide. Previous studies assessing the possible relationship between indoor radon exposure and COPD have shown inconclusive results. A multicentric, hospital-based, case-control study was conducted in a Spanish radon-prone area. COPD cases were confirmed by spirometry and controls were selected due to trivial surgery or procedures not related to tobacco consumption. All participants had to have lived for at least 15 years in the same dwelling. Radon measurements were conducted individually in dwellings using alpha-track detectors. Results were obtained using multivariate logistic regression. 189 cases and 747 controls took part. There was no significant association between residential radon concentrations and COPD onset with a OR of 1.12 (95%CI 0.41-3.06) for individuals exposed to more than 200Bq/m No association between indoor radon and COPD has been observed. However, there might be some effect modification on the COPD risk in heavy smokers when high radon exposure is present. This is supported by the additive synergy observed. Also, a possible association between indoor radon and COPD onset in never and light smokers needs to be further studied.
Sections du résumé
BACKGROUND
BACKGROUND
COPD is a multifactorial disease which causes considerable mortality and morbidity worldwide. Previous studies assessing the possible relationship between indoor radon exposure and COPD have shown inconclusive results.
METHODS
METHODS
A multicentric, hospital-based, case-control study was conducted in a Spanish radon-prone area. COPD cases were confirmed by spirometry and controls were selected due to trivial surgery or procedures not related to tobacco consumption. All participants had to have lived for at least 15 years in the same dwelling. Radon measurements were conducted individually in dwellings using alpha-track detectors. Results were obtained using multivariate logistic regression.
RESULTS
RESULTS
189 cases and 747 controls took part. There was no significant association between residential radon concentrations and COPD onset with a OR of 1.12 (95%CI 0.41-3.06) for individuals exposed to more than 200Bq/m
CONCLUSIONS
CONCLUSIONS
No association between indoor radon and COPD has been observed. However, there might be some effect modification on the COPD risk in heavy smokers when high radon exposure is present. This is supported by the additive synergy observed. Also, a possible association between indoor radon and COPD onset in never and light smokers needs to be further studied.
Identifiants
pubmed: 35699045
pii: S1579-2129(21)00321-9
doi: 10.1016/j.arbr.2020.11.020
pii:
doi:
Substances chimiques
Radon
Q74S4N8N1G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
630-636Informations de copyright
Copyright © 2020 SEPAR. Published by Elsevier España, S.L.U. All rights reserved.