Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity.

CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes COVID-19 / immunology COVID-19 Vaccines Cytokines / immunology Female Humans Immunity Immunologic Memory Interferon-gamma / metabolism Interleukin-2 / immunology Male SARS-CoV-2 Severity of Illness Index Time Factors
ELISpot assay SARS-CoV-2 T cell immunity cytokines granzyme B immune modeling

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
13 07 2022
Historique:
pubmed: 15 6 2022
medline: 26 7 2022
entrez: 14 6 2022
Statut: ppublish

Résumé

Cell-mediated immunity is critical for long-term protection against most viral infections, including coronaviruses. We studied 23 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected survivors over a 1-year post-symptom onset (PSO) interval by

Identifiants

DOI: 10.1128/jvi.00509-22 PMID: 35699447 PMC: PMC9278147
pubmed: 35699447
doi: 10.1128/jvi.00509-22
pmc: PMC9278147
doi:

Substances chimiques

COVID-19 Vaccines 0
Cytokines 0
Interleukin-2 0
spike protein, SARS-CoV-2 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0050922

Subventions

Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
ID : VR1-172711

Commentaires et corrections

Type : ErratumIn

Auteurs

Jonah Lin (J)

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Ryan Law (R)

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Chapin S Korosec (CS)

Modelling Infection and Immunity Lab, Centre for Disease Modelling, Department of Mathematics and Statistics, York Universitygrid.21100.32, Toronto, Ontario, Canada.

Christine Zhou (C)

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Wan Hon Koh (WH)

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Mohammad Sajjad Ghaemi (MS)

Digital Technologies Research Centre, National Research Council Canadagrid.24433.32, Toronto, Ontario, Canada.

Philip Samaan (P)

Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathobiology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Hsu Kiang Ooi (HK)

Digital Technologies Research Centre, National Research Council Canadagrid.24433.32, Toronto, Ontario, Canada.
ORCID: 0000-0001-7934-4866

Vitaliy Matveev (V)

Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

FengYun Yue (F)

Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Anne-Claude Gingras (AC)

Lunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
Department of Medical Genetics, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Antonio Estacio (A)

Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.

Megan Buchholz (M)

Apheresis Unit, Kidney and Metabolism Program, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.

Patti Lou Cheatley (PL)

Apheresis Unit, Kidney and Metabolism Program, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.

Avid Mohammadi (A)

Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Rupert Kaul (R)

Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.

Katerina Pavinski (K)

Department of Laboratory Medicine, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.

Samira Mubareka (S)

Sunnybrook Health Sciences Centre and Research Institute, Toronto, Ontario, Canada.

Allison J McGeer (AJ)

Lunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.

Jerome A Leis (JA)

Sunnybrook Health Sciences Centre and Research Institute, Toronto, Ontario, Canada.

Jane M Heffernan (JM)

Modelling Infection and Immunity Lab, Centre for Disease Modelling, Department of Mathematics and Statistics, York Universitygrid.21100.32, Toronto, Ontario, Canada.

Mario Ostrowski (M)

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Institute of Medical Science, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathobiology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
ORCID: 0000-0002-7369-1936

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Longitudinal Assessment of SARS-CoV-2-Specific...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Longitudinal Assessment of SARS-CoV-2-Specific...