Efficacy and safety of modified BLd therapy for Japanese patients with transplant-ineligible multiple myeloma.
BLd regimen
Japanese cohort
Multiple myeloma
Prospective analysis
Transplant ineligible
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
22
10
2021
accepted:
25
04
2022
revised:
25
04
2022
pubmed:
15
6
2022
medline:
30
9
2022
entrez:
14
6
2022
Statut:
ppublish
Résumé
The BLd regimen, which is a triplet regimen of bortezomib (Bor), lenalidomide (Len), and dexamethasone (Dex), is effective against newly diagnosed multiple myeloma (NDMM). However, non-hematological toxicities, such as peripheral neuropathy (PN), often hamper long-term continuation of the regimen, particularly in older adult patients. In this study, we examined the efficacy and safety of the modified BLd regimen with reduced-intensity Bor and standard-dose Len. The chemotherapy regimen consisted of 1.3 mg/m
Identifiants
pubmed: 35699890
doi: 10.1007/s12185-022-03379-9
pii: 10.1007/s12185-022-03379-9
doi:
Substances chimiques
Bortezomib
69G8BD63PP
Dexamethasone
7S5I7G3JQL
Lenalidomide
F0P408N6V4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
563-569Informations de copyright
© 2022. Japanese Society of Hematology.
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