Post-transplant cyclophosphamide pharmacokinetics and haploidentical hematopoietic cell transplantation outcomes: an exploratory study.

Humans Graft vs Host Disease / etiology Transplantation Conditioning / adverse effects Chromatography, Liquid Neoplasm Recurrence, Local Tandem Mass Spectrometry Hematopoietic Stem Cell Transplantation / adverse effects Cyclophosphamide / adverse effects Retrospective Studies
CEPM GVHD PTCy haplo-HCT pharmacokinetics

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
Nov 2022
Historique:
pubmed: 15 6 2022
medline: 15 11 2022
entrez: 14 6 2022
Statut: ppublish

Résumé

Pharmacokinetics of cyclophosphamide has been explored to optimize conditioning dosing. We hypothesized that post-transplant cyclophosphamide (PTCy) metabolite carboxy-ethyl phosphoramide mustard (CEPM) pharmacokinetics might impact haploidentical transplantation (haplo-HCT) outcomes. CEPM area under the curve (AUC

Identifiants

DOI: 10.1080/10428194.2022.2087067 PMID: 35699967
pubmed: 35699967
doi: 10.1080/10428194.2022.2087067
doi:

Substances chimiques

Cyclophosphamide 8N3DW7272P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2679-2685

Auteurs

Kripa Shanker Kasudhan (KS)

Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Amol N Patil (AN)

Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
ORCID: 0000-0001-8552-2796

Aditya Jandial (A)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Alka Khadwal (A)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Gaurav Prakash (G)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Arihant Jain (A)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Dinesh Bhurani (D)

Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
ORCID: 0000-0001-8066-8913

Rayaz Ahmed (R)

Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Narendra Agrawal (N)

Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Reema Singh (R)

Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Man Updesh Singh Sachdeva (MUS)

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Neelam Varma (N)

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Reena Das (R)

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
ORCID: 0000-0002-8938-5423

Savita Verma Attri (S)

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Samir Malhotra (S)

Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Navneet S Majhail (NS)

Blood and Marrow Transplant Program, Department of Hematology-Oncology, Cleveland Clinic, Cleveland, OH, USA.

Pankaj Malhotra (P)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Deepesh P Lad (DP)

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
ORCID: 0000-0003-3754-7774

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Post-transplant cyclophosphamide...
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › Post-transplant cyclophosphamide...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Conditionnement pour greffe › Post-transplant cyclophosphamide...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Post-transplant cyclophosphamide...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Post-transplant cyclophosphamide...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Post-transplant cyclophosphamide...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Post-transplant cyclophosphamide...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphoramides › Moutardes phosphoramide › Cyclophosphamide › Post-transplant cyclophosphamide...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Post-transplant cyclophosphamide...