Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer.

Animals Calcineurin / chemistry Calcineurin Inhibitors Cyclosporine / pharmacology Humans Mice NFATC Transcription Factors / metabolism Phosphoric Monoester Hydrolases / metabolism Triple Negative Breast Neoplasms / drug therapy
Calcineurin Docking-based design Druggability evaluation NFAT signaling Inhibitor PxIxIT SAR exploration Triple negative breast cancer

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Aug 2022
Historique:
received: 11 04 2022
revised: 01 06 2022
accepted: 02 06 2022
pubmed: 15 6 2022
medline: 24 6 2022
entrez: 14 6 2022
Statut: ppublish

Résumé

The Ca2

Identifiants

DOI: 10.1016/j.ejmech.2022.114514 PMID: 35700596
pubmed: 35700596
pii: S0223-5234(22)00416-0
doi: 10.1016/j.ejmech.2022.114514
pii:
doi:

Substances chimiques

Calcineurin Inhibitors 0
NFATC Transcription Factors 0
Cyclosporine 83HN0GTJ6D
Calcineurin EC 3.1.3.16
Phosphoric Monoester Hydrolases EC 3.1.3.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114514

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Adrià Sánchez-Morales (A)

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.

Atilla Biçer (A)

Genes, Disease and Therapy Program, Human Molecular Genetics Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain.

Vasilis Panagiotopoulos (V)

Department of Biomedical Engineering, University of West Attica, Egaleo, Athens, 12210, Greece.

Selma Crecente-Garcia (S)

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.

Cristina Benaiges (C)

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.

Sergi Bayod (S)

Health & Biomedicine Department of LEITAT Technological Center, Parc Científic de Barcelona, Hèlix building. Baldiri Reixach 15-21, Barcelona, 08028, Spain.

José Luís Hernández (J)

Health & Biomedicine Department of LEITAT Technological Center, Parc Científic de Barcelona, Hèlix building. Baldiri Reixach 15-21, Barcelona, 08028, Spain.

Félix Busqué (F)

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain.

Minos-Timotheos Matsoukas (MT)

Department of Biomedical Engineering, University of West Attica, Egaleo, Athens, 12210, Greece. Electronic address: mmatsoukas@uniwa.gr.

Mercè Pérez-Riba (M)

Genes, Disease and Therapy Program, Human Molecular Genetics Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08908, Spain. Electronic address: mpr@idibell.cat.

Ramon Alibés (R)

Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 08193, Spain. Electronic address: ramon.alibes@uab.cat.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Calcineurine › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la calcineurine › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclosporines › Ciclosporine › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription NFATC › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Design and synthesis of a novel non peptide...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Design and synthesis of a novel non peptide...