Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer.

BRCA1 BRCA2 Consensus Hereditary breast cancer Hereditary ovarian cancer Panel testing

Journal

Breast care (Basel, Switzerland)
ISSN: 1661-3791
Titre abrégé: Breast Care (Basel)
Pays: Switzerland
ID NLM: 101254060

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 05 01 2021
accepted: 17 03 2021
entrez: 15 6 2022
pubmed: 16 6 2022
medline: 16 6 2022
Statut: ppublish

Résumé

The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

Sections du résumé

Background UNASSIGNED
The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer.
Summary UNASSIGNED
An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process.
Key Messages UNASSIGNED
The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.

Identifiants

DOI: 10.1159/000516376 PMID: 35702495 PMC: PMC9149395
pubmed: 35702495
doi: 10.1159/000516376
pii: brc-0017-0199
pmc: PMC9149395
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

199-207

Informations de copyright

Copyright © 2021 by S. Karger AG, Basel.

Déclaration de conflit d'intérêts

Christopher Schroeder reports research support from Illumina and Bristol Myers Squibb and institutional research support from Novartis.

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Auteurs

Kerstin Rhiem (K)

Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Bernd Auber (B)

Department of Human Genetics, Hannover Medical School, Hannover, Germany.

Susanne Briest (S)

Department of Obstetrics and Gynaecology, University Hospital of Leipzig, Leipzig, Germany.

Nicola Dikow (N)

Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.

Nina Ditsch (N)

Department of Gynecology and Obstetrics, University Hospital of Augsburg, Augsburg, Germany.

Neda Dragicevic (N)

Institute of Human Genetics, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

Sabine Grill (S)

Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technical University Munich (TUM), Munich, Germany.

Eric Hahnen (E)

Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Judit Horvath (J)

Institute for Human Genetics, University Hospital Münster, Münster, Germany.

Bernadette Jaeger (B)

Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.

Karin Kast (K)

Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Marion Kiechle (M)

Department of Gynecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technical University Munich (TUM), Munich, Germany.

Elena Leinert (E)

Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.

Susanne Morlot (S)

Department of Human Genetics, Hannover Medical School, Hannover, Germany.

Michael Püsken (M)

Department of Radiology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Dieter Schäfer (D)

Institute for Human Genetics, University of Frankfurt, Frankfurt, Germany.

Sarah Schott (S)

Department of Obstetrics and Gynaecology, University of Heidelberg, Heidelberg, Germany.

Christopher Schroeder (C)

Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.

Ulrike Siebers-Renelt (U)

Institute for Human Genetics, University Hospital Münster, Münster, Germany.

Christine Solbach (C)

Department of Gynecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany.

Nana Weber-Lassalle (N)

Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Isabell Witzel (I)

Department of Obstetrics and Gynaecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Christine Zeder-Göß (C)

Department of Gynecology and Obstetrics, University Hospital of Augsburg, Augsburg, Germany.

Rita K Schmutzler (RK)

Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology, Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.

Classifications MeSH