Phenotypes and Genotypes in Postherpetic Neuralgia Drug Therapy: A Narrative Mini-review.


Journal

The Clinical journal of pain
ISSN: 1536-5409
Titre abrégé: Clin J Pain
Pays: United States
ID NLM: 8507389

Informations de publication

Date de publication:
01 08 2022
Historique:
received: 08 10 2021
accepted: 03 05 2022
pubmed: 16 6 2022
medline: 15 7 2022
entrez: 15 6 2022
Statut: epublish

Résumé

Neuropathic pain is a debilitating symptom reported by patients presenting with postherpetic neuralgia (PHN). Efforts to alleviate this pain have been projected to lie in individualization of pharmacological treatment through pain phenotyping and subsequent investigations into the genetic basis of PHN therapy. Understanding the various mechanisms related to these phenotypes can aid in improvement of available treatment options and discovery of new ones. Knowledge and application of genetic variations in PHN, structural proteins, and genes can aid in ascertaining risk, susceptibility to, severity of, and protection from PHN. This review summarizes the most recent information that has been published on phenotypes and genotypes with possible clinical applications and directions for future research.

Identifiants

pubmed: 35703453
doi: 10.1097/AJP.0000000000001045
pii: 00002508-202208000-00004
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

536-540

Informations de copyright

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Udochukwu G Anosike (UG)

Faculty of Medicine, Nnamdi Azikiwe University College of Health Sciences, Awka, Nigeria.

Innocent Ouko (I)

Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.

Anita W Mwaura (AW)

Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.

Ibsen Ongidi (I)

Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.

Chijioke C Mbonu (CC)

Faculty of Medicine, Nnamdi Azikiwe University College of Health Sciences, Awka, Nigeria.

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