Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.

Animals Calreticulin / genetics Cancer Vaccines Humans Janus Kinase 2 / genetics Major Histocompatibility Complex Mice Mice, Inbred C57BL Mutation / genetics Myeloproliferative Disorders / genetics Neoplasms / genetics Peptides Vaccines, Subunit

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
15 06 2022
Historique:
entrez: 15 6 2022
pubmed: 16 6 2022
medline: 18 6 2022
Statut: ppublish

Résumé

The majority of JAK2

Identifiants

DOI: 10.1126/scitranslmed.aba4380 PMID: 35704596
pubmed: 35704596
doi: 10.1126/scitranslmed.aba4380
doi:

Substances chimiques

Calreticulin 0
Cancer Vaccines 0
Peptides 0
Vaccines, Subunit 0
Janus Kinase 2 EC 2.7.10.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaba4380

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL131835
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA056821
Pays : United States

Auteurs

Mathieu Gigoux (M)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0002-1831-7597

Morten O Holmström (MO)

Department of Oncology, National Center for Cancer Immune Therapy, Herlev Hospital, Herlev 2730, Denmark.
Department of Immunology and Microbiology, Copenhagen University Hospital, Herlev 2730, Denmark.
ORCID: 0000-0002-3764-8578

Roberta Zappasodi (R)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
ORCID: 0000-0002-7031-6671

Joseph J Park (JJ)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medical College, New York, NY 10065, USA.
ORCID: 0000-0003-1311-5416

Stephane Pourpe (S)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cansu Cimen Bozkus (CC)

Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
ORCID: 0000-0001-7834-4792

Levi M B Mangarin (LMB)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0003-1219-6998

David Redmond (D)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10065, USA.
ORCID: 0000-0002-0983-8606

Svena Verma (S)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medical College, New York, NY 10065, USA.

Sara Schad (S)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medical College, New York, NY 10065, USA.

Mariam M George (MM)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0003-3166-6844

Divya Venkatesh (D)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Arnab Ghosh (A)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0003-3355-5427

David Hoyos (D)

Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Zaki Molvi (Z)

Weill Cornell Medicine, New York, NY 10065, USA.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0001-6728-4835

Baransel Kamaz (B)

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9910-6141

Anna E Marneth (AE)

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-9065-0581

William Duke (W)

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Matthew J Leventhal (MJ)

Broad Institute, Cambridge, MA 02142, USA.
ORCID: 0000-0002-5995-5202

Max Jan (M)

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
ORCID: 0000-0002-7071-5517

Vincent T Ho (VT)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Gabriela S Hobbs (GS)

Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
ORCID: 0000-0002-0199-9333

Trine Alma Knudsen (TA)

Department of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
ORCID: 0000-0001-9829-3099

Vibe Skov (V)

Department of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
ORCID: 0000-0003-0097-7826

Lasse Kjær (L)

Department of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.

Thomas Stauffer Larsen (TS)

Department of Hematology, Odense University Hospital, Odense 5000, Denmark.

Dennis Lund Hansen (DL)

Department of Hematology, Odense University Hospital, Odense 5000, Denmark.
ORCID: 0000-0002-4478-1297

R Coleman Lindsley (RC)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-9822-806X

Hans Hasselbalch (H)

Department of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
ORCID: 0000-0003-3936-8032

Jacob H Grauslund (JH)

Department of Oncology, National Center for Cancer Immune Therapy, Herlev Hospital, Herlev 2730, Denmark.
Department of Immunology and Microbiology, Copenhagen University Hospital, Herlev 2730, Denmark.

Thomas L Lisle (TL)

Department of Oncology, National Center for Cancer Immune Therapy, Herlev Hospital, Herlev 2730, Denmark.
Department of Immunology and Microbiology, Copenhagen University Hospital, Herlev 2730, Denmark.
ORCID: 0000-0002-6667-7706

Özcan Met (Ö)

Department of Oncology, National Center for Cancer Immune Therapy, Herlev Hospital, Herlev 2730, Denmark.
Department of Immunology and Microbiology, Copenhagen University Hospital, Herlev 2730, Denmark.
ORCID: 0000-0002-3256-7592

Patrick Wilkinson (P)

Janssen Oncology Therapeutic Area, Janssen Research and Development, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, PA 19002, USA.
ORCID: 0000-0002-2274-4110

Benjamin Greenbaum (B)

Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medicine, Physiology, Biophysics and Systems Biology, Weill Cornell Medical College, New York, NY 10065, USA.

Manuel A Sepulveda (MA)

Janssen Oncology Therapeutic Area, Janssen Research and Development, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, PA 19002, USA.
ORCID: 0000-0001-7196-7823

Timothy Chan (T)

Weill Cornell Medical College, New York, NY 10065, USA.
Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0002-9265-0283

Raajit Rampal (R)

Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Mads H Andersen (MH)

Department of Oncology, National Center for Cancer Immune Therapy, Herlev Hospital, Herlev 2730, Denmark.
Department of Immunology and Microbiology, Copenhagen University Hospital, Herlev 2730, Denmark.
ORCID: 0000-0002-2914-9605

Omar Abdel-Wahab (O)

Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0002-3907-6171

Nina Bhardwaj (N)

Parker Institute for Cancer Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
ORCID: 0000-0003-1865-4187

Jedd D Wolchok (JD)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medical College, New York, NY 10065, USA.
ORCID: 0000-0001-6718-2222

Ann Mullally (A)

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Broad Institute, Cambridge, MA 02142, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-9727-8495

Taha Merghoub (T)

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program and Immuno-Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Weill Cornell Medical College, New York, NY 10065, USA.
ORCID: 0000-0002-1518-5111

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Calréticuline › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins anticancéreux › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinase Janus-2 › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myéloprolifératifs › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Tumeurs › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Calreticulin mutant myeloproliferative...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins sous-unitaires › Calreticulin mutant myeloproliferative...