Lessons from Acquired Natural Immunity and Clinical Trials to Inform Next-Generation Human Cytomegalovirus Vaccine Development.
acquired natural immunity
animal model
clinical trial
human cytomegalovirus
immune correlates of protection
next-generation vaccine
Journal
Annual review of virology
ISSN: 2327-0578
Titre abrégé: Annu Rev Virol
Pays: United States
ID NLM: 101625721
Informations de publication
Date de publication:
29 09 2022
29 09 2022
Historique:
pubmed:
16
6
2022
medline:
4
10
2022
entrez:
15
6
2022
Statut:
ppublish
Résumé
Human cytomegalovirus (HCMV) infection, the most common cause of congenital disease globally, affecting an estimated 1 million newborns annually, can result in lifelong sequelae in infants, such as sensorineural hearing loss and brain damage. HCMV infection also leads to a significant disease burden in immunocompromised individuals. Hence, an effective HCMV vaccine is urgently needed to prevent infection and HCMV-associated diseases. Unfortunately, despite more than five decades of vaccine development, no successful HCMV vaccine is available. This review summarizes what we have learned from acquired natural immunity, including innate and adaptive immunity; the successes and failures of HCMV vaccine human clinical trials; the progress in related animal models; and the analysis of protective immune responses during natural infection and vaccination settings. Finally, we propose novel vaccine strategies that will harness the knowledge of protective immunity and employ new technology and vaccine concepts to inform next-generation HCMV vaccine development.
Identifiants
pubmed: 35704747
doi: 10.1146/annurev-virology-100220-010653
pmc: PMC10154983
mid: NIHMS1892870
doi:
Substances chimiques
Cytomegalovirus Vaccines
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-520Subventions
Organisme : NIAID NIH HHS
ID : P01 AI129859
Pays : United States
Références
Curr Opin Mol Ther. 2009 Oct;11(5):572-8
pubmed: 19806506
J Infect Dis. 1994 Nov;170(5):1100-9
pubmed: 7963701
Vaccine. 2018 Mar 14;36(12):1689-1699
pubmed: 29456015
J Infect Dis. 2012 Apr 15;205(8):1294-304
pubmed: 22402037
Cell. 2016 Sep 8;166(6):1471-1484.e18
pubmed: 27610571
J Immunol Methods. 2014 Jul;409:91-8
pubmed: 24120573
PLoS Pathog. 2018 Dec 3;14(12):e1007452
pubmed: 30507948
Vaccines (Basel). 2019 Sep 29;7(4):
pubmed: 31569508
J Virol. 2021 Mar 3;95(10):
pubmed: 33658350
Cell Rep. 2016 May 3;15(5):1088-1099
pubmed: 27117418
J Infect Dis. 2020 Mar 5;221(Suppl 1):S113-S122
pubmed: 32134478
J Infect Dis. 2006 May 15;193(10):1350-60
pubmed: 16619181
J Med Virol. 1994 May;43(1):103-10
pubmed: 8083644
J Clin Pathol. 2001 Feb;54(2):84-8
pubmed: 11215290
AIDS. 1996 Oct;10(12):1331-7
pubmed: 8902061
PLoS Pathog. 2015 Oct 20;11(10):e1005227
pubmed: 26484870
Vaccines (Basel). 2020 Jul 20;8(3):
pubmed: 32698362
J Antimicrob Chemother. 2006 Apr;57(4):585-8
pubmed: 16504998
Science. 2013 May 24;340(6135):1237874
pubmed: 23704576
J Immunol. 2003 Feb 15;170(4):2030-6
pubmed: 12574373
Clin Microbiol Rev. 2002 Oct;15(4):680-715
pubmed: 12364375
Vaccine. 2016 Apr 12;34(17):1993-9
pubmed: 26973071
J Transl Med. 2015 Feb 15;13:60
pubmed: 25879820
Nature. 2020 Oct;586(7830):567-571
pubmed: 32756549
J Infect Dis. 2022 Apr 19;225(8):1399-1410
pubmed: 32313928
NPJ Vaccines. 2021 Jun 2;6(1):79
pubmed: 34078915
Clin Pharmacol Drug Dev. 2020 May;9(4):444-455
pubmed: 32202705
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1915-9
pubmed: 19181844
Arch Dis Child. 2019 Jun;104(6):559-563
pubmed: 30472664
Viral Immunol. 2001;14(4):369-77
pubmed: 11792066
Sci Transl Med. 2020 Nov 4;12(568):
pubmed: 33148624
Vet Microbiol. 2002 Apr 22;86(1-2):69-88
pubmed: 11888691
J Infect Dis. 1995 Jan;171(1):26-32
pubmed: 7798679
Vaccine. 2016 Jan 12;34(3):313-9
pubmed: 26657184
J Virol. 2008 Jan;82(1):60-70
pubmed: 17942555
J Virol. 2011 May;85(10):5150-8
pubmed: 21367908
J Infect Dis. 2016 Nov 1;214(9):1341-1348
pubmed: 27521362
Nat Med. 2018 Feb;24(2):130-143
pubmed: 29334373
N Engl J Med. 2021 Sep 16;385(12):e35
pubmed: 34525286
Transplantation. 2011 Aug 15;92(3):267-70
pubmed: 21659947
Blood. 1997 Sep 1;90(5):1751-67
pubmed: 9292508
EClinicalMedicine. 2021 Mar 19;33:100787
pubmed: 33842870
Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6273-6278
pubmed: 29686064
J Infect Dis. 2020 Mar 5;221(Suppl 1):S123-S127
pubmed: 32134484
JAMA. 2021 Apr 20;325(15):1535-1544
pubmed: 33704352
N Engl J Med. 1989 Jun 29;320(26):1731-5
pubmed: 2543925
Nat Immunol. 2010 Dec;11(12):1127-35
pubmed: 20972432
Trends Microbiol. 2004 Oct;12(10):458-65
pubmed: 15381195
J Infect Dis. 1999 Sep;180(3):843-6
pubmed: 10438376
J Infect Dis. 1989 May;159(5):851-9
pubmed: 2540246
Placenta. 2017 Dec;60 Suppl 1:S73-S79
pubmed: 28456432
Clin Infect Dis. 2013 Dec;57 Suppl 4:S193-5
pubmed: 24257426
Clin Infect Dis. 2012 Jun;54(11):1615-7
pubmed: 22437237
Blood Adv. 2020 Apr 14;4(7):1388-1406
pubmed: 32271902
J Infect Dis. 2021 Jun 4;223(11):2001-2012
pubmed: 33031517
Vaccines (Basel). 2019 Sep 26;7(4):
pubmed: 31561584
J Virol. 2017 Jul 12;91(15):
pubmed: 28490582
Lancet Haematol. 2016 Feb;3(2):e87-98
pubmed: 26853648
J Clin Invest. 2014 Dec;124(12):5305-16
pubmed: 25384219
J Infect Dis. 2018 May 25;217(12):1907-1917
pubmed: 29528415
Am J Transplant. 2018 Dec;18(12):2945-2954
pubmed: 29745007
Vaccines (Basel). 2014 May 14;2(2):354-79
pubmed: 26344623
Methods Mol Biol. 2022;2412:145-178
pubmed: 34918245
Nat Immunol. 2015 Sep;16(9):927-32
pubmed: 26193080
Hum Vaccin Immunother. 2013 Oct;9(10):2081-94
pubmed: 23811579
N Engl J Med. 2012 Apr 5;366(14):1275-86
pubmed: 22475592
Microbiol Mol Biol Rev. 2016 Jun 15;80(3):663-77
pubmed: 27307580
J Exp Med. 2005 Jun 20;201(12):1999-2010
pubmed: 15967826
EBioMedicine. 2022 Feb;76:103841
pubmed: 35085851
J Infect Dis. 1995 May;171(5):1115-21
pubmed: 7751685
N Engl J Med. 1992 Mar 5;326(10):663-7
pubmed: 1310525
Blood. 2008 Aug 1;112(3):914-5
pubmed: 18650467
Blood. 2003 Oct 1;102(7):2498-505
pubmed: 12805061
Vaccine. 2009 Dec 11;28(2):484-93
pubmed: 19857446
PLoS Pathog. 2016 Feb 11;12(2):e1005355
pubmed: 26866914
JAMA. 2003 Feb 26;289(8):1008-11
pubmed: 12597753
PLoS One. 2013;8(3):e59863
pubmed: 23555812
J Clin Immunol. 2012 Dec;32(6):1324-31
pubmed: 22836657
J Infect Dis. 2007 Jun 15;195(12):1789-98
pubmed: 17492595
Clin Vaccine Immunol. 2017 Jan 5;24(1):
pubmed: 27795301
Blood. 2001 Sep 1;98(5):1358-64
pubmed: 11520783
Curr Opin HIV AIDS. 2019 Mar;14(2):137-142
pubmed: 30562176
Curr Opin Immunol. 2008 Feb;20(1):30-8
pubmed: 18206359
J Exp Med. 2005 Sep 5;202(5):673-85
pubmed: 16147978
Nat Immunol. 2018 May;19(5):453-463
pubmed: 29632329
Vaccines (Basel). 2020 Feb 17;8(1):
pubmed: 32079250
Pediatr Infect Dis J. 2002 Feb;21(2):133-8
pubmed: 11840080
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Clin Exp Immunol. 2007 Aug;149(2):205-10
pubmed: 17635529
Am J Transplant. 2013 Jul;13(7):1793-805
pubmed: 23711167
Clin Infect Dis. 2010 Jun 1;50(11):1439-47
pubmed: 20426575
Clin Infect Dis. 2013 Dec;57 Suppl 4:S178-81
pubmed: 24257422
Future Virol. 2013 Dec 1;8(12):1151-1160
pubmed: 24465269
Sci Adv. 2021 Mar 5;7(10):
pubmed: 33674318
PLoS One. 2019 Jan 23;14(1):e0210252
pubmed: 30673723
Vaccines (Basel). 2021 May 25;9(6):
pubmed: 34070277
New Microbiol. 2019 Jan;42(1):1-20
pubmed: 30671581
J Infect Dis. 2001 Apr 15;183(8):1171-9
pubmed: 11262198
Nat Immunol. 2019 Aug;20(8):1004-1011
pubmed: 31263280
Blood. 2012 Mar 15;119(11):2665-74
pubmed: 22180440
Clin Infect Dis. 2017 Oct 30;65(10):1659-1665
pubmed: 29020188
Clin Vaccine Immunol. 2014 Feb;21(2):174-80
pubmed: 24334684
Clin Infect Dis. 2004 Apr 1;38(7):1035-7
pubmed: 15034839
J Exp Med. 1988 Sep 1;168(3):919-31
pubmed: 2844952
Hum Vaccin. 2005 Jan-Feb;1(1):16-23
pubmed: 17038834
Trends Microbiol. 2020 Nov;28(11):900-912
pubmed: 32448762
PLoS Pathog. 2011 Jan 13;7(1):e1001256
pubmed: 21249233
PLoS Pathog. 2017 Aug 30;13(8):e1006601
pubmed: 28854233
J Infect Dis. 2008 Jun 15;197(12):1634-42
pubmed: 18444883
J Virol. 2004 Sep;78(18):10023-33
pubmed: 15331735
Int J Hematol. 2017 Feb;105(2):206-212
pubmed: 27796740
Lancet Infect Dis. 2012 Apr;12(4):290-9
pubmed: 22237175
Cell Rep. 2020 May 12;31(6):107624
pubmed: 32402293
Antimicrob Agents Chemother. 2017 Jan 24;61(2):
pubmed: 27872061
Biomolecules. 2021 Jul 21;11(8):
pubmed: 34439738
Clin Infect Dis. 2009 Dec 15;49(12):1777-83
pubmed: 19911937
Viruses. 2009;1(3):362
pubmed: 20151027
Curr Opin Virol. 2017 Aug;25:126-133
pubmed: 28888133
Nat Immunol. 2005 Feb;6(2):181-8
pubmed: 15640804
Blood. 2017 Jan 5;129(1):114-125
pubmed: 27760761
J Nanobiotechnology. 2021 Feb 25;19(1):59
pubmed: 33632278
J Infect Dis. 2003 Dec 15;188(12):1868-74
pubmed: 14673766
Clin Vaccine Immunol. 2017 Dec 5;24(12):
pubmed: 29046308
J Virol. 2015 Sep;89(17):8999-9009
pubmed: 26085146
Expert Opin Pharmacother. 2001 Aug;2(8):1247-57
pubmed: 11584992
J Virol. 1996 Nov;70(11):7569-79
pubmed: 8892876
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13645-50
pubmed: 26483473
J Infect Dis. 2020 Mar 5;221(Suppl 1):S45-S59
pubmed: 32134477
Immunity. 2015 Mar 17;42(3):443-56
pubmed: 25786176
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18153-8
pubmed: 16319222
EMBO J. 1986 Nov;5(11):3057-63
pubmed: 3024973
Transplantation. 1994 Dec 15;58(11):1176-8
pubmed: 7992358
J Gen Virol. 2008 Apr;89(Pt 4):853-865
pubmed: 18343825
J Virol. 1999 Oct;73(10):8179-84
pubmed: 10482568
Biol Blood Marrow Transplant. 2019 Apr;25(4):771-784
pubmed: 30562587
J Clin Invest. 2022 Aug 15;132(16):
pubmed: 35763348
J Virol. 2008 Oct;82(20):10143-52
pubmed: 18684826
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
J Infect Dis. 2007 Nov 1;196(9):1304-12
pubmed: 17922394
J Infect Dis. 1999 Nov;180(5):1700-3
pubmed: 10515836
Clin Dev Immunol. 2013;2013:906948
pubmed: 24000289
Nature. 2009 Jan 29;457(7229):557-61
pubmed: 19136945
N Engl J Med. 2009 Mar 19;360(12):1191-9
pubmed: 19297572
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):99-106
pubmed: 8680896
Lancet. 2011 Apr 9;377(9773):1256-63
pubmed: 21481708
J Intern Med. 2010 May;267(5):483-501
pubmed: 20433576
J Infect Dis. 2016 Dec 15;214(12):1916-1923
pubmed: 27923951
J Clin Virol. 2008 Mar;41(3):206-12
pubmed: 18069056
Nat Biotechnol. 2012 May 07;30(5):423-33
pubmed: 22565972
J Gen Virol. 2006 Sep;87(Pt 9):2451-2460
pubmed: 16894182
Annu Rev Immunol. 2013;31:163-94
pubmed: 23298212
J Exp Med. 1998 May 18;187(10):1681-7
pubmed: 9584146
Vaccines (Basel). 2014 Jul 29;2(3):624-41
pubmed: 26344749
J Infect Dis. 1981 Apr;143(4):585-9
pubmed: 6263984
Vaccines (Basel). 2020 Sep 14;8(3):
pubmed: 32937764
J Infect Dis. 2020 Mar 5;221(Suppl 1):S60-S73
pubmed: 32134481
N Engl J Med. 2005 Sep 29;353(13):1350-62
pubmed: 16192480
Hum Gene Ther. 2018 Sep;29(9):1029-1043
pubmed: 29869530
J Infect Dis. 2019 Jul 2;220(3):411-419
pubmed: 31535143
NPJ Vaccines. 2018 Sep 20;3:38
pubmed: 30275984
Adv Anat Embryol Cell Biol. 1977;53(2):5-91
pubmed: 331890
Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6267-6272
pubmed: 29712861
Obstet Med. 2014 Dec;7(4):140-6
pubmed: 27512442
Virus Genes. 2017 Aug;53(4):650-655
pubmed: 28391502
J Virol. 2015 Dec;89(23):11884-98
pubmed: 26378171
Cell. 2015 Nov 5;163(4):988-98
pubmed: 26544943
Reproduction. 2020 Dec;160(6):R129-R143
pubmed: 33112767
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Virology. 1992 Nov;191(1):387-95
pubmed: 1329327
J Infect Dis. 2007 Apr 1;195(7):1062-70
pubmed: 17330798
Crit Rev Clin Lab Sci. 2019 Mar;56(2):118-145
pubmed: 30632863
Clin Dev Immunol. 2013;2013:501801
pubmed: 24023565
Vaccine. 2008 Sep 19;26(40):5223-9
pubmed: 18468743
Front Cell Infect Microbiol. 2020 Sep 17;10:476
pubmed: 33072616
J Virol. 1992 Jan;66(1):341-8
pubmed: 1309250
J Infect Dis. 2019 Jul 31;220(5):772-780
pubmed: 31107951