Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer.


Journal

European journal of cancer (Oxford, England : 1990)
ISSN: 1879-0852
Titre abrégé: Eur J Cancer
Pays: England
ID NLM: 9005373

Informations de publication

Date de publication:
08 2022
Historique:
received: 11 03 2022
revised: 18 04 2022
accepted: 25 04 2022
pubmed: 16 6 2022
medline: 20 7 2022
entrez: 15 6 2022
Statut: ppublish

Résumé

Although SARS-CoV-2 vaccines immunogenicity in patients with cancer has been investigated, whether they can significantly improve the severity of COVID-19 in this specific population is undefined. Capitalizing on OnCovid (NCT04393974) registry data we reported COVID-19 mortality and proxies of COVID-19 morbidity, including post-COVID-19 outcomes, according to the vaccination status of the included patients. 2090 eligible patients diagnosed with COVID-19 between 02/2020 and 11/2021 were included, of whom 1930 (92.3%) unvaccinated, 91 (4.4%) fully vaccinated and 69 (3.3%) partially vaccinated. With the exception of a higher prevalence of patients from the UK (p = 0.0003) and receiving systemic anticancer therapy at COVID-19 diagnosis (p = 0.0082) among fully vaccinated patients, no demographics/oncological features were associated with vaccination status. The 14-days case fatality rate (CFR) (5.5% vs 20.7%, p = 0.0004) and the 28-days CFR (13.2% vs 27.4%, p = 0.0028) demonstrated a significant improvement for fully vaccinated patients in comparison with unvaccinated patients. The receipt of prior full vaccination was also associated with reduced symptomatic COVID-19 (79.1% vs 88.5%, p = 0.0070), need of COVID-19 oriented therapy (34.9% vs 63.2%, p < 0.0001), complications from COVID-19 (28.6% vs 39.4%, p = 0.0379), hospitalizations due to COVID-19 (42.2% vs 52.5%, p = 0.0007) and oxygen therapy requirement (35.7% vs 52%, p = 0.0036). Following Inverse Probability Treatment Weighting (IPTW) procedure no statistically significant difference according to the vaccination status was confirmed; however, all COVID-19 related outcomes were concordantly in favour of full vaccination. Among the 1228 (58.8%) patients who underwent a formal reassessment at participating centres after COVID-19 resolution, fully vaccinated patients experienced less sequelae than unvaccinated patients (6.7% vs 17.2%, p = 0.0320). This analysis provides initial evidence in support of the beneficial effect of SARS-CoV-2 vaccines against morbidity and mortality from COVID-19 in patients with cancer.

Sections du résumé

BACKGROUND
Although SARS-CoV-2 vaccines immunogenicity in patients with cancer has been investigated, whether they can significantly improve the severity of COVID-19 in this specific population is undefined.
METHODS
Capitalizing on OnCovid (NCT04393974) registry data we reported COVID-19 mortality and proxies of COVID-19 morbidity, including post-COVID-19 outcomes, according to the vaccination status of the included patients.
RESULTS
2090 eligible patients diagnosed with COVID-19 between 02/2020 and 11/2021 were included, of whom 1930 (92.3%) unvaccinated, 91 (4.4%) fully vaccinated and 69 (3.3%) partially vaccinated. With the exception of a higher prevalence of patients from the UK (p = 0.0003) and receiving systemic anticancer therapy at COVID-19 diagnosis (p = 0.0082) among fully vaccinated patients, no demographics/oncological features were associated with vaccination status. The 14-days case fatality rate (CFR) (5.5% vs 20.7%, p = 0.0004) and the 28-days CFR (13.2% vs 27.4%, p = 0.0028) demonstrated a significant improvement for fully vaccinated patients in comparison with unvaccinated patients. The receipt of prior full vaccination was also associated with reduced symptomatic COVID-19 (79.1% vs 88.5%, p = 0.0070), need of COVID-19 oriented therapy (34.9% vs 63.2%, p < 0.0001), complications from COVID-19 (28.6% vs 39.4%, p = 0.0379), hospitalizations due to COVID-19 (42.2% vs 52.5%, p = 0.0007) and oxygen therapy requirement (35.7% vs 52%, p = 0.0036). Following Inverse Probability Treatment Weighting (IPTW) procedure no statistically significant difference according to the vaccination status was confirmed; however, all COVID-19 related outcomes were concordantly in favour of full vaccination. Among the 1228 (58.8%) patients who underwent a formal reassessment at participating centres after COVID-19 resolution, fully vaccinated patients experienced less sequelae than unvaccinated patients (6.7% vs 17.2%, p = 0.0320).
CONCLUSIONS
This analysis provides initial evidence in support of the beneficial effect of SARS-CoV-2 vaccines against morbidity and mortality from COVID-19 in patients with cancer.

Identifiants

pubmed: 35704976
pii: S0959-8049(22)00276-3
doi: 10.1016/j.ejca.2022.04.036
pmc: PMC9124924
pii:
doi:

Substances chimiques

COVID-19 Vaccines 0

Banques de données

ClinicalTrials.gov
['NCT04393974']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

64-74

Investigateurs

David J Pinato (DJ)
Joanne S Evans (JS)
Judith Swallow (J)
Alessio Cortellini (A)
Georgina Hanbury (G)
Chris Chung (C)
Meera Patel (M)
Gino Dettorre (G)
Diego Ottaviani (D)
Amani Chowdhury (A)
Alvin Jx Lee (AJ)
Christopher Ct Sng (CC)
Tamara Yu (T)
Marianne Shawe-Taylor (M)
Hamish Dc Bain (HD)
Alasdair Sinclair (A)
Lee Cooper (L)
Lucy Rogers (L)
Katherine Belessiotis (K)
Cian Murphy (C)
Samira Bawany (S)
Saira Khalique (S)
Ramis Andaleeb (R)
Mark Bower (M)
Alessia Dalla Pria (A)
Rachel Sharkey (R)
Thomas Newsom-Davis (T)
Saorise Dolly (S)
Ailsa Sita-Lumsde (A)
Eleanor Apthorp (E)
Eleanor Jones (E)
Mieke Van Hemelrijck (M)
Charlotte Moss (C)
Beth Russell (B)
Eleanor Apthorp (E)
Nikolaos Diamantis (N)
Uma Mukherjee (U)
Sarah Townsend (S)
Amanda Jackson (A)
Angela Loizidou (A)
Martine Piccart (M)
Aleix Prat (A)
Claudia A Cruz (CA)
Roxana Reyes (R)
Elia Segui (E)
Javier Marco-Hernández (J)
Margarita Viladot (M)
Josep Tabernero (J)
Juan Aguilar-Company (J)
Isabel Ruiz-Camps (I)
Laura Fox (L)
David Garcia Illescas (D)
Nadia Saoudi (N)
Oriol Mirallas (O)
Elisa Roldán (E)
Joan Brunet (J)
MCarmen Carmona Garcia (M)
Robert Fort-Culillas (R)
Raquel Liñan (R)
Nadia Harbeck (N)
Rachel Wuerstlein (R)
Franziska Henze (F)
Sven Mahner (S)
Ricard Mesia (R)
Eudald Felip (E)
Andrea Plaja (A)
Marc Cucurull (M)
Ramon Salazar (R)
Anna Sureda (A)
Clara Maluquer (C)
Alessandra Gennari (A)
Federica Biello (F)
Francesca D'Avanzo (F)
Gianluca Gaidano (G)
Riccardo Bruna (R)
Andrea Patriarca (A)
Daniela Ferrante (D)
Lorenza Scotti (L)
Marco Krengly (M)
Paolo Pedrazzoli (P)
Gianpiero Rizzo (G)
Alexia Bertuzzi (A)
Sabrina Rossi (S)
Andrea Marrari (A)
Armando Santoro (A)
Lorenza Rimassa (L)
Federica Grosso (F)
Vittorio Fusco (V)
Sara Delfanti (S)
Antonio Maconi (A)
Marta Betti (M)
Bruno Vincenzi (B)
Giuseppe Tonini (G)
Alberto Zambelli (A)
Carlo Tondini (C)
Vittoria Fotia (V)
Lorenzo Chiudinelli (L)
Michela Franchi (M)
Michela Libertini (M)
Rossella Bertulli (R)
Salvatore Provenzano (S)
Daniele Generali (D)
Salvatore Grisanti (S)
Alice Baggi (A)
Valeria Tovazzi (V)
Corrado Ficorella (C)
Giampiero Porzio (G)
Alessandro Parisi (A)
Paola Queirolo (P)
Maristella Saponara (M)
Raffaele Giusti (R)
Marco Filetti (M)
Francesca Mazzoni (F)
Federica Zoratto (F)
Marco Tucci (M)
Rossana Berardi (R)
Luca Cantini (L)
Francesco Paoloni (F)
Annalisa Guida (A)
Sergio Bracarda (S)
Clara Martinez-Vila (C)
Maria Iglesias (M)
Ana Sanchez de Torre (A)
Matteo Lambertini (M)
Marta Perachino (M)
Fanny Pommeret (F)
Emeline Colomba (E)

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: As corresponding author of the abovementioned manuscript, I declare on behalf of my co-authors the following conflict of interests: David J Pinato received lecture fees from ViiV Healthcare, Bayer Healthcare, BMS, Roche, EISAI, Falk Foundation, travel expenses from BMS and Bayer Healthcare; consulting fees for Mina Therapeutics, EISAI, Roche, DaVolterra and Astra Zeneca; research funding (to institution) from MSD and BMS.Aleix Prat has declared personal honoraria from Pfizer, Roche, MSD Oncology, Eli Lilly, and Daiichi Sankyo; travel, accommodations, and expenses paid by Daiichi Sankyo; research funding from Roche and Novartis; and consulting/advisory role for NanoString Technologies, Amgen, Roche, Novartis, Pfizer and Bristol-Myers Squibb.Matteo Lambertini acted as consultant for Roche, Novartis, Lilly, AstraZeneca, Exact Sciences, MSD, Pfizer, Seagen and received speaker honoraria from Roche, Novartis, Lilly, Pfizer, Takeda, Ipsen and Sandoz outside the submitted work.Joan Brunet has declared consulting/advisory role for MSD and Astra Zeneca.Alessandra Gennari has declared consulting/advisory role for Roche, MSD, Eli Lilly, Pierre Fabre, EISAI, and Daichii Sankyo; speakers bureau for Eisai, Novartis, Eli Lilly, Roche, Teva, Gentili, Pfizer, Astra Zeneca, Celgene, and Daichii Sankyo; research funds: EISAI, Eli Lilly, and Roche. CMV has received travel grants and other honoraria from BMS, MSD, Novartis and Roche.Gianluca Gaidano has declared consulting/advisory role for Janssen, Abbvie, Astra-Zeneca and BeiGene, and speaker fees from Janssen and Abbvie.Lorenza Rimassa received consulting fees from Taiho Oncology, Servier, Amgen, ArQule, AstraZeneca, Basilea, Bayer, BMS, Celgene, Eisai, Exelixis, Genenta, Hengrui, Incyte, Ipsen, IQVIA, Lilly, MSD, Nerviano Medical Sciences, Roche, Sanofi, Zymeworks; lecture fees from AbbVie, Amgen, Bayer, Eisai, Gilead, Incyte, Ipsen, Lilly, Merck Serono, Roche, Sanofi; travel expenses from Ipsen; and institutional research funding from Agios, ARMO BioSciences, AstraZeneca, BeiGene, Eisai, Exelixis, Fibrogen, Incyte, Ipsen, Lilly, MSD, Nerviano Medical Sciences, Roche, Zymeworks.Joseph Tabernero reported consulting fees from Array Biopharma, AstraZeneca, Avvinity, Bayer, Boehringer Ingelheim, Chugai, Daiichi Sankyo, F. Hoffmann-La Roche Ltd, Genentech Inc, HalioDX SAS, Hutchison MediPharma International, Ikena Oncology, Inspirna Inc, IQVIA, Lilly, Menarini, Merck Serono, Merus, MSD, Mirati, Neophore, Novartis, Ona Therapeutics, Orion Biotechnology, Peptomyc, Pfizer, Pierre Fabre, Samsung Bioepis, Sanofi, Seattle Genetics, Scandion Oncology, Servier, Sotio Biotech, Taiho, Tessa Therapeutics and TheraMyc. He also reported speaker's fees from Imedex, Medscape Education, MJH Life Sciences, PeerView Institute for Medical Education and Physicians Education Resource (PER). He also declared institutional research support from Amgen Inc, Array Biopharma Inc, AstraZeneca Pharmaceuticals LP, BeiGene, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Debiopharm International SA, F. Hoffmann-La Roche Ltd, Genentech Inc, HalioDX SAS, Hutchison MediPharma International, Janssen-Cilag SA, MedImmune, Menarini, Merck Health KGAA, Merck Sharp & Dohme, Merus NV, Mirati, Novartis Farmacéutica SA, Pfizer, Pharma Mar, Sanofi Aventis Recherche & Développement, Servier, Taiho Pharma USA Inc, Spanish Association Against Cancer Scientific Foundation and Cancer Research UK.Alessio Cortellini received consulting fees from MSD, BMS, AstraZeneca, Roche; speakers' fee from AstraZeneca, MSD, Novartis and Eisai.All remaining authors have declared no conflicts of interest.London, April 18th, 2022.

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Auteurs

David J Pinato (DJ)

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK; Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Daniela Ferrante (D)

Department of Translational Medicine, Unit of Medical Statistics, University of Piemonte Orientale, Novara, Italy.

Juan Aguilar-Company (J)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain; Infectious Diseases, Vall D'Hebron University Hospital, Barcelona, Spain.

Mark Bower (M)

Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.

Ramon Salazar (R)

Department of Medical Oncology, ICO L'Hospitalet, Oncobell Program (IDIBELL), CIBERONC, Hospitalet de Llobregat, Spain.

Oriol Mirallas (O)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.

Anna Sureda (A)

Haematology Department, ICO Hospitalet, Hospitalet de Llobregat, IDIBELL, Universitat de Barcelona, Barcelona, Spain.

Alexia Bertuzzi (A)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Joan Brunet (J)

Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, Girona, Spain.

Matteo Lambertini (M)

Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy.

Clara Maluquer (C)

Haematology Department, ICO Hospitalet, Hospitalet de Llobregat, IDIBELL, Universitat de Barcelona, Barcelona, Spain.

Paolo Pedrazzoli (P)

Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia Italy.

Federica Biello (F)

Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Alvin J X Lee (AJX)

Cancer Division, University College London Hospitals, London, UK.

Christopher C T Sng (CCT)

Cancer Division, University College London Hospitals, London, UK.

Raquel Liñan (R)

Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, Girona, Spain.

Sabrina Rossi (S)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

M Carmen Carmona-García (MC)

Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, Girona, Spain.

Rachel Sharkey (R)

Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.

Simeon Eremiev (S)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.

Gianpiero Rizzo (G)

Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Hamish Dc Bain (HD)

Cancer Division, University College London Hospitals, London, UK.

Tamara Yu (T)

Cancer Division, University College London Hospitals, London, UK.

Claudia A Cruz (CA)

Department of Medical Oncology, Hospital Clinic, Barcelona, Spain.

Marta Perachino (M)

Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy.

Nadia Saoudi-Gonzalez (N)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.

Roser Fort-Culillas (R)

Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, Girona, Spain.

Kris Doonga (K)

Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.

Laura Fox (L)

Department of Hematology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.

Elisa Roldán (E)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.

Federica Zoratto (F)

Medical Oncology, St Maria Goretti Hospital, Latina, Italy.

Gianluca Gaidano (G)

Division of Haematology, Department of Translational Medicine, University of Piemonte Orientale and Maggiore Della Carità Hospital, Novara, Italy.

Isabel Ruiz-Camps (I)

Infectious Diseases, Vall D'Hebron University Hospital, Barcelona, Spain.

Riccardo Bruna (R)

Division of Haematology, Department of Translational Medicine, University of Piemonte Orientale and Maggiore Della Carità Hospital, Novara, Italy.

Andrea Patriarca (A)

Division of Haematology, Department of Translational Medicine, University of Piemonte Orientale and Maggiore Della Carità Hospital, Novara, Italy.

Marianne Shawe-Taylor (M)

Cancer Division, University College London Hospitals, London, UK.

Vittorio Fusco (V)

Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", Alessandria, Italy.

Clara Martinez-Vila (C)

Fundació Althaia Manresa, Manresa, Spain.

Rossana Berardi (R)

Medical Oncology, AOU Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy.

Marco Filetti (M)

Medical Oncology, St. Andrea Hospital, Rome, Italy.

Francesca Mazzoni (F)

Medical Oncology, Careggi University Hospital, Florence, Italy.

Armando Santoro (A)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20090 Pieve Emanuele, Milan, Italy.

Sara Delfanti (S)

Mesothelioma Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Alessandro Parisi (A)

Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Paola Queirolo (P)

Melanoma and Sarcoma Medical Treatment Unit, IEO - Istituto Europeo di Oncologia, Milan, Italy.

Avinash Aujayeb (A)

Respiratory Department, Northumbria Healthcare NHS Foundation Trust, North Shields, UK.

Lorenza Rimassa (L)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20090 Pieve Emanuele, Milan, Italy.

Aleix Prat (A)

Department of Medical Oncology, Hospital Clinic, Barcelona, Spain; Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.

Josep Tabernero (J)

Medical Oncology, Vall D'Hebron University Hospital and Institute of Oncology (VHIO), IOB-Quiron, UVic-UCC, Barcelona, Spain.

Alessandra Gennari (A)

Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Alessio Cortellini (A)

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK. Electronic address: alessiocortellini@gmail.com.

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