COVID-19 Vaccines and the Efficacy of Currently Available Vaccines Against COVID-19 Variants.
booster dose
corona
covaxin
efficacy
moderna
omicron
vaccine
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
accepted:
11
05
2022
entrez:
16
6
2022
pubmed:
17
6
2022
medline:
17
6
2022
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus 2 is the seventh member of the Coronaviridiae family of viruses, which are thought to be transmitted by Chinese horseshoe bats. The virus undergoes mutations leading to variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617 (delta), as well as the recent variant B.1.1.529 (omicron), which has around 30 deletions, making it a severely mutated form that lowers vaccination-induced protection. Vaccine efficacy is usually expressed as relative risk reduction, which is based on the ratio of attack rates with and without a vaccine, whereas absolute risk reduction is based on the entire population. Rather than two doses, recent research suggests that a third dose/booster dose may aid in protection against future variants. The constant influx of mutant variations is putting a strain on vaccine production. Despite the challenges, we are optimistic that the epidemic will be eradicated by achieving mass immunity and by ensuring that everyone receives vaccines at a faster rate.
Identifiants
pubmed: 35706739
doi: 10.7759/cureus.24927
pmc: PMC9187843
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e24927Informations de copyright
Copyright © 2022, Panneer Selvam et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
N Engl J Med. 2020 Oct 15;383(16):1544-1555
pubmed: 32722908
N Engl J Med. 2021 Jun 10;384(23):2187-2201
pubmed: 33882225
J Med Virol. 2022 May;94(5):1825-1832
pubmed: 35023191
Viruses. 2021 Mar 09;13(3):
pubmed: 33803400
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Lancet. 2020 Jun 13;395(10240):1845-1854
pubmed: 32450106
N Engl J Med. 2020 Sep 17;383(12):1191
pubmed: 32813941
Lancet. 2021 Dec 19;396(10267):1979-1993
pubmed: 33220855
JAMA Netw Open. 2021 Nov 1;4(11):e2132540
pubmed: 34726743
Lancet. 2021 Mar 6;397(10277):881-891
pubmed: 33617777
EClinicalMedicine. 2021 Oct;40:101126
pubmed: 34541480
Lancet. 2021 Jun 26;397(10293):2461-2462
pubmed: 34139198
Cell. 2021 May 27;184(11):2939-2954.e9
pubmed: 33852911
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Nat Med. 2021 Feb;27(2):270-278
pubmed: 33335323
Cell Death Differ. 2021 Feb;28(2):626-639
pubmed: 33479399
Emerg Microbes Infect. 2020 Dec;9(1):221-236
pubmed: 31987001
Lancet. 2020 Aug 15;396(10249):467-478
pubmed: 32702298
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Nature. 2021 Apr;592(7854):438-443
pubmed: 33690265
Lancet. 2021 Dec 11;398(10317):2173-2184
pubmed: 34774196
Nature. 2020 Oct;586(7830):594-599
pubmed: 32998157
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Nat Microbiol. 2020 Oct;5(10):1185-1191
pubmed: 32908214
J Virol. 2012 Dec;86(23):12816-25
pubmed: 22993147
J Adv Res. 2020 Mar 16;24:91-98
pubmed: 32257431
N Engl J Med. 2022 Feb 3;386(5):494-496
pubmed: 34965358
Euro Surveill. 2021 Mar;26(11):
pubmed: 33739254
PLoS Comput Biol. 2021 Sep 7;17(9):e1009380
pubmed: 34491988
BMJ. 2021 Aug 20;374:n1943
pubmed: 34417165
Nat Med. 2021 Dec;27(12):2127-2135
pubmed: 34650248
Lancet Infect Dis. 2021 May;21(5):637-646
pubmed: 33485468
Nat Med. 2021 Apr;27(4):620-621
pubmed: 33558724
Nat Med. 2021 Feb;27(2):279-288
pubmed: 33335322
Nature. 2020 Oct;586(7830):589-593
pubmed: 32785213
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
Lancet. 2021 Feb 20;397(10275):671-681
pubmed: 33545094
Lancet. 2020 Sep 26;396(10255):887-897
pubmed: 32896291
Lancet. 2021 May 1;397(10285):1646-1657
pubmed: 33901420
Curr Opin Immunol. 2016 Aug;41:47-54
pubmed: 27286566
Nature. 2021 May;593(7858):270-274
pubmed: 33723411
Pediatr Allergy Immunol. 2021 Jan;32(1):9-16
pubmed: 33113210
N Engl J Med. 2022 Jan 6;386(1):35-46
pubmed: 34752019
Nat Rev Immunol. 2020 Jun;20(6):339-341
pubmed: 32317716
Nat Commun. 2021 Jul 26;12(1):4598
pubmed: 34312390
Nature. 2020 Oct;586(7830):516-527
pubmed: 32967006
N Engl J Med. 2021 Aug 12;385(7):585-594
pubmed: 34289274
bioRxiv. 2020 May 13;:
pubmed: 32511340
N Engl J Med. 2021 Aug 5;385(6):571-572
pubmed: 34289271
Lancet Microbe. 2021 Jul;2(7):e279-e280
pubmed: 33899038
Biomed J. 2020 Aug;43(4):328-333
pubmed: 32387617
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
N Engl J Med. 2021 Jan 7;384(1):80-82
pubmed: 33270381
Lancet. 2021 Mar 6;397(10277):875-877
pubmed: 33610193