Non-stereotactic radiotherapy in older cancer patients.
Frailty
Geriatrics
Radiation oncology
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
02
09
2021
revised:
19
01
2022
accepted:
25
05
2022
entrez:
16
6
2022
pubmed:
17
6
2022
medline:
17
6
2022
Statut:
epublish
Résumé
Old or very old oncological patients represent a heterogeneous and frail population due to concomitant comorbidities. Whether radiotherapy alone or in combination with novel cancer drugs may provide a clear benefit in this setting of patients is still a matter of debate. The aim of our review is to analyze the evaluation process and the different therapeutic possibilities in older cancer patients, focusing on the different and most disparate applications of radiotherapy. We reviewed the most recent literature on radiotherapy in older patients providing clinical evidence of treatment related toxicity, tolerance and outcomes using standard fractionated and/or hypofractionated irradiation alone or in combination with chemotherapy, targeted and immunotherapy. In older cancer patients unfit for systemic therapy or surgery, radiotherapy represents a valid therapeutic approach, both with curative and palliative intents, ensuring excellent patient compliance in terms of local toxicity and adherence to therapy.
Identifiants
pubmed: 35706953
doi: 10.1016/j.heliyon.2022.e09593
pii: S2405-8440(22)00881-7
pmc: PMC9189877
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e09593Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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