Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
09 Jun 2022
Historique:
received: 13 12 2021
accepted: 13 05 2022
entrez: 16 6 2022
pubmed: 17 6 2022
medline: 17 6 2022
Statut: epublish

Résumé

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the parasite

Identifiants

pubmed: 35707144
doi: 10.1021/acsmedchemlett.1c00690
pmc: PMC9190044
doi:

Types de publication

Journal Article

Langues

eng

Pagination

904-910

Informations de copyright

© 2022 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Lorena Zara (L)

Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Francesca Moraca (F)

Schrodinger, Inc., 1540 Broadway, New York, New York 10036, United States.

Jacqueline E Van Muijlwijk-Koezen (JE)

Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Barbara Zarzycka (B)

Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Robert Abel (R)

Schrodinger, Inc., 1540 Broadway, New York, New York 10036, United States.

Iwan J P de Esch (IJP)

Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Classifications MeSH