Human Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?
Flavivirus
GB virus
Pegivirus
immune modulation
viral co-infection
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
03
2022
accepted:
03
05
2022
entrez:
16
6
2022
pubmed:
17
6
2022
medline:
18
6
2022
Statut:
epublish
Résumé
Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C). Sequence analyses found these two isolates to be the same virus, and subsequent studies found that the virus does not cause hepatitis despite sharing genome organization with hepatitis C virus. Although HGV/GBV-C infection is common and may cause persistent infection in humans, the virus does not appear to directly cause any other known disease state. Thus, the virus was renamed "human pegivirus 1" (HPgV-1) for "persistent G" virus. HPgV-1 is found primarily in lymphocytes and not hepatocytes, and several studies found HPgV-1 infection associated with prolonged survival in people living with HIV. Co-infection of human lymphocytes with HPgV-1 and HIV inhibits HIV replication. Although three viral proteins directly inhibit HIV replication
Identifiants
pubmed: 35707535
doi: 10.3389/fimmu.2022.887760
pmc: PMC9190258
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
887760Subventions
Organisme : BLRD VA
ID : I01 BX000207
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Informations de copyright
Copyright © 2022 Stapleton.
Déclaration de conflit d'intérêts
The author JS has patents related to the use of GB virus C in the potential treatment of HIV-1 infection.
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