An Ultrasound-Responsive Theranostic Cyclodextrin-Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis.
atherosclerosis
cyclodextrin
polybutylcyanoacrylate
theranostics
ultrasound imaging
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
24
05
2022
received:
14
02
2022
pubmed:
18
6
2022
medline:
6
8
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
Atherosclerosis is a major cause of mortality and morbidity worldwide. Left undiagnosed and untreated, atherosclerotic plaques can rupture and cause cardiovascular complications such as myocardial infarction and stroke. Atherosclerotic plaques are composed of lipids, including oxidized low-density lipoproteins and cholesterol crystals, and immune cells, including macrophages. 2-Hydroxypropyl-beta-cyclodextrin (CD) is FDA-approved for capturing, solubilizing, and delivering lipophilic drugs in humans. It is also known to dissolve cholesterol crystals and decrease atherosclerotic plaque size. However, its low retention time necessitates high dosages for successful therapy. This study reports CD delivery via air-trapped polybutylcyanoacrylate nanoparticles (with diameters of 388 ± 34 nm) loaded with CD (CDNPs). The multimodal contrast ability of these nanoparticles after being loaded with IR780 dye in mice is demonstrated using ultrasound and near-infrared imaging. It is shown that CDNPs enhance the cellular uptake of CD in murine cells. In an ApoE
Identifiants
pubmed: 35710979
doi: 10.1002/smll.202200967
doi:
Substances chimiques
Cyclodextrins
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200967Informations de copyright
© 2022 The Authors. Small published by Wiley-VCH GmbH.
Références
S. Zimmer, A. Grebe, S. S. Bakke, N. Bode, B. Halvorsen, T. Ulas, M. Skjelland, D. De Nardo, L. I. Labzin, A. Kerksiek, C. Hempel, M. T. Heneka, V. Hawxhurst, M. L. Fitzgerald, J. Trebicka, I. Björkhem, J.-Å. Gustafsson, M. Westerterp, A. R. Tall, S. D. Wright, T. Espevik, J. L. Schultze, G. Nickenig, D. Lütjohann, E. Latz, Sci. Transl. Med. 2016, 8, 333ra50.
Y.-C. Chen, A. L. Huang, T. S. Kyaw, A. Bobik, K. Peter, Arterioscler., Thromb., Vasc. Biol. 2016, 36, e63.
X. Wang, K. Peter, Arterioscler., Thromb., Vasc. Biol. 2017, 37, 1029.
P. Duewell, H. Kono, K. J. Rayner, C. M. Sirois, G. Vladimer, F. G. Bauernfeind, G. S. Abela, L. Franchi, G. Nunez, M. Schnurr, T. Espevik, E. Lien, K. A. Fitzgerald, K. L. Rock, K. J. Moore, S. D. Wright, V. Hornung, E. Latz, Nature 2010, 464, 1357.
M. S. Bittencourt, R. J. Cerci, BMC Med. 2015, 13, 260.
P. Libby, Am. J. Cardiol. 2003, 91, 4B.
Y.-n. Cao, L. Xu, Y.-c. Han, Y.-n. Wang, G. Liu, R. Qi, Drug Discovery Today 2017, 22, 180.
R. A. Hegele, S. Tsimikas, Circ. Res. 2019, 124, 386.
S. Kühnast, M. C. Louwe, M. M. Heemskerk, E. J. Pieterman, J. B. van Klinken, S. A. A. van den Berg, J. W. A. Smit, L. M. Havekes, P. C. N. Rensen, J. W. A. van der Hoorn, H. M. G. Princen, J. W. Jukema, PLoS One 2013, 8, e66467.
B. L. Sanchez-gaytan, F. Fay, M. E. Lobatto, J. Tang, M. Ouimet, Y. Kim, S. E. M. V. D. Staay, S. M. V. Rijs, B. Priem, L. Zhang, E. A. Fisher, K. J. Moore, R. Langer, Z. A. Fayad, W. J. M. Mulder, 2015, 26, 443.
C. Ward Natalie, F. Watts Gerald, H. Eckel Robert, Circ. Res. 2019, 124, 328.
S. R. Salim Yusuf, S. Ôunpuu, S. Anand, Circulation 2001, 104, 2746.
M. Flores Alyssa, J. Ye, K.-U. Jarr, N. Hosseini-Nassab, R. Smith Bryan, J. Leeper Nicholas, Arterioscler., Thromb., Vasc. Biol. 2019, 39, 635.
H. Kim, J. Han, J.-H. Park, J. Controlled Release 2020, 319, 77.
D. R. Lewis, L. K. Petersen, A. W. York, K. R. Zablocki, L. B. Joseph, V. Kholodovych, R. K. Prud'homme, K. E. Uhrich, P. V. Moghe, Proc. Natl. Acad. Sci. USA 2015, 112, 2693.
L. Szente, A. Singhal, A. Domokos, B. Song, Molecules 2018, 23, 1228
A. Singhal, E. S. Krystofiak, W. G. Jerome, B. Song, Sci. Rep. 2020, 10, 8663.
S. S. Bakke, M. H. Aune, N. Niyonzima, K. Pilely, L. Ryan, M. Skjelland, P. Garred, P. Aukrust, B. Halvorsen, E. Latz, J. K. Damås, T. E. Mollnes, T. Espevik, J. Immunol. 2017, 199, 2910.
M. Abdur Rouf, I. Vural, E. Bilensoy, A. Hincal, D. D. Erol, J. Inclusion Phenom. Macrocyclic Chem. 2011, 70, 167.
D. Carradori, H. Chen, B. Werner, A. S. Shah, C. Leonardi, M. Usuelli, R. Mezzenga, F. Platt, J.-C. Leroux, Small 2020, 16, 2004735.
P. Jansook, N. Ogawa, T. Loftsson, Int. J. Pharm. 2018, 535, 272.
H. Kim, S. Kumar, D.-W. Kang, H. Jo, J.-H. Park, ACS Nano 2020, 14, 6519.
Y. Dou, Y. Chen, S. Han, X. Xu, Q. Shi, J. Zhang, J. Guo, Y. Jia, Y. Liu, Y. Deng, X. Li, R. Wang, J. Controlled Release 2016, 235, 48.
X. Jin, S. Asghar, X. Zhu, Z. Chen, C. Tian, L. Yin, Q. Ping, Y. Xiao, Colloids Surf., B 2018, 162, 25.
J. N. Blythe, A. Habib, A. Gulati, P. A. Brennan, Br. J. Oral Maxillofac. Surg. 2011, 49, 486.
R. M. Koffie, C. T. Farrar, L.-J. Saidi, C. M. William, B. T. Hyman, T. L. Spires-Jones, Proc. Natl. Acad. Sci. USA 2011, 108, 18837.
M. Liu, A. Dasgupta, P. Koczera, S. Schipper, D. Rommel, Y. Shi, F. Kiessling, T. Lammers, Mol. Pharmaceutics 2020, 17, 2840.
B. Li, R. Aid-Launais, M.-N. Labour, A. Zenych, M. Juenet, C. Choqueux, V. Ollivier, O. Couture, D. Letourneur, C. Chauvierre, Biomaterials 2019, 194, 139.
L. Appold, Y. Shi, S. Rütten, A. Kühne, A. Pich, F. Kiessling, T. Lammers, Macromol. Biosci. 2017, 17, 1700002.
G. Dufour, B. Evrard, P. de Tullio, AAPS J. 2015, 17, 1501.
R. Chandan, R. Banerjee, Sci. Rep. 2018, 8, 2624.
T. Kyaw, C. Tay, A. Khan, V. Dumouchel, A. Cao, K. To, M. Kehry, R. Dunn, A. Agrotis, P. Tipping, A. Bobik, B.-H. Toh, J. Immunol. 2010, 185, 4410.
F. Tranquart, M. Arditi, T. Bettinger, P. Frinking, J. M. Hyvelin, A. Nunn, S. Pochon, I. Tardy, Z. Gastroenterol. 2014, 52, 1268.
A. Prabhakar, R. Banerjee, ACS Omega 2019, 4, 15567.
J. A.-T. Walker, X. Wang, K. Peter, K. Kempe, S. R. Corrie, ACS Sens. 2020, 5, 1190.
K. Rajamäki, J. Lappalainen, K. Oörni, E. Välimäki, S. Matikainen, P. T. Kovanen, K. K. Eklund, PLoS One 2010, 5, e11765.
J. L. Ramírez-Zacarías, F. Castro-Muñozledo, W. Kuri-Harcuch, Histochemistry 1992, 97, 493.
P. Koczera, L. Appold, Y. Shi, M. Liu, A. Dasgupta, V. Pathak, T. Ojha, S. Fokong, Z. Wu, M. van Zandvoort, O. Iranzo, A. J. C. Kuehne, A. Pich, F. Kiessling, T. Lammers, J Controlled Release 2017, 259, 128.
N. Behan, C. Birkinshaw, N. Clarke, Biomaterials 2001, 22, 1335.
M. Danaei, M. Dehghankhold, S. Ataei, F. Hasanzadeh Davarani, R. Javanmard, A. Dokhani, S. Khorasani, M. R. Mozafari, Pharmaceutics 2018, 10, 57.
M. Stein, E. Hamacher, Int. J. Pharm. 1992, 80, R11.
C. O'sullivan, C. Birkinshaw, Polym. Degrad. Stab. 2002, 78, 7.
A. L. Klibanov, J. A. Hossack, Invest. Radiol. 2015, 50, 657.
Y.-L. Xu, Y.-H. Gao, Z. Liu, K.-B. Tan, X. Hua, Z.-Q. Fang, Y.-L. Wang, Y.-J. Wang, H.-M. Xia, Z.-X. Zhuo, Int. J. Cardiol. 2010, 138, 182.
X. Wang, E. Hagemeyer Christoph, D. Hohmann Jan, E. Leitner, C. Armstrong Paul, F. Jia, M. Olschewski, A. Needles, K. Peter, I. Ahrens, Circulation 2012, 125, 3117.
M. Liu, P. Zhang, L. Deng, D. Guo, M. Tan, J. Huang, Y. Luo, Y. Cao, Z. Wang, Biomater. Sci. 2019, 7, 1132.
J.-W. Muller, R. van Hees, M. van Sambeek, P. Boutouyrie, M. Rutten, P. Brands, M. Wu, R. Lopata, Biomed. Opt. Express 2021, 12, 4207.
T. Ojha, V. Pathak, N. Drude, M. Weiler, D. Rommel, S. Rütten, B. Geinitz, M. J. van Steenbergen, G. Storm, F. Kiessling, T. Lammers, Pharmaceutics 2019, 11, 433
R. Chandan, S. M. Mehta, R. Banerjee, ACS Biomater. Sci. Eng. 2020, 6, 4731.
H. Yuan, H. Hu, J. Sun, M. Shi, H. Yu, C. Li, Y. U. Sun, Z. Yang, R. M. Hoffman, In Vivo 2018, 32, 1025.
C. Prasad, E. Bhatia, R. Banerjee, Sci. Rep. 2020, 10, 8587.
R. Challa, A. Ahuja, J. Ali, R. K. Khar, AAPS PharmSciTech 2005, 6, E329.
E. Sulheim, H. Baghirov, E. von Haartman, A. Bøe, A. K. O. Åslund, Y. Mørch, C. d. L. Davies, J. Nanobiotechnol. 2016, 14, 1.
H. T. Ta, N. P. Truong, A. K. Whittaker, T. P. Davis, K. Peter, Expert Opin. Drug Delivery 2018, 15, 33.
S. Feng, L. Nie, P. Zou, J. Suo, J. Appl. Polym. Sci. 2015, 132, 41431.
J. V. Tapia-Vieyra, B. Delgado-Coello, J. Mas-Oliva, Arch. Med. Res. 2017, 48, 12.
A. R. Mendelsohn, J. W. Larrick, Rejuvenation Res. 2016, 19, 252.
E. M. Wagner, K.-L. C. Jen, J. D. Artiss, A. T. Remaley, Metabolism 2008, 57, 1046.
P. F. Garrido, M. Calvelo, A. Blanco-González, U. Veleiro, F. Suárez, D. Conde, A. Cabezón, Á. Piñeiro, R. Garcia-Fandino, Int. J. Pharm. 2020, 588, 119689.
R. M. Graham David, E. Chertova, M. Hilburn Joanne, O. Arthur Larry, E. K. Hildreth James, J. Virol. 2003, 77, 8237.