Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics.

antibacterial antitumor nanozyme pro-oxidative therapeutic

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2022
Historique:
received: 21 02 2022
accepted: 20 04 2022
entrez: 17 6 2022
pubmed: 18 6 2022
medline: 18 6 2022
Statut: epublish

Résumé

Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therapeutics. In this context, composite nanozymes are advantageous, particularly because they integrate the properties of various nanomaterials to offer a single multifunctional platform combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). Hence, recent years have witnessed great progress in engineering composite nanozymes for enhanced pro-oxidative activity that can be utilized in therapeutics. Therefore, the present review traverses over the newer strategies to design composite nanozymes as pro-oxidative therapeutics. It provides recent trends in the use of composite nanozymes as antibacterial, antibiofilm, and antitumor agents. This review also analyzes various challenges yet to be overcome by pro-oxidative composite nanozymes before being used in the field.

Identifiants

pubmed: 35711631
doi: 10.3389/fbioe.2022.880214
pii: 880214
pmc: PMC9197165
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

880214

Informations de copyright

Copyright © 2022 Maddheshiya and Nara.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Shilpa Maddheshiya (S)

Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India.

Seema Nara (S)

Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India.

Classifications MeSH