Electrical Impedance Myography in Dogs With Degenerative Myelopathy.

Canine degenerative myelopathy (DM) leads to disuse and neurogenic muscle atrophy. Currently there is a lack of non-invasive quantitative measures of muscle health in dogs with DM. Muscle pathology has been previously quantified in other disorders using the technique of electrical impedance myography (EIM) but it has not been reported for DM. The objective of this study was to compare EIM between DM-affected and similar aged healthy dogs as well as assess EIM changes over time in DM-affected dogs. Multifrequency EIM was performed on DM affected dogs at baseline and during disease progression and on age-matched healthy dogs. Muscles evaluated in the pelvic limbs included the craniotibialis, gastrocnemius, gracilis, sartorius, and biceps femoris. The 100 kHz phase angle was extracted from the full frequency set for analysis. Phase values were lower in DM dogs as compared to healthy controls. Specifically, phase of the gastrocnemius was lower on the left (θ = 7.69, 13.06;

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Copyright © 2022 Kowal, Verga, Pandeya, Cochran, Sabol, Rutkove and Coates.

Déclaration de conflit d'intérêts

SR has equity in, and serves a consultant and scientific advisor to Myolex, Inc. and Haystack Diagnostics, companies that design impedance devices for clinical and research use; he is also a member of the company's Board of Directors. The companies also have an option to license patented impedance technology of which SR is named as an inventor. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.