Immensely High Creatine Kinase Levels in a Case of Rhabdomyolysis Due to Legionnaires' Disease in a Patient on Tofacitinib: A Case Report and Literature Review.
Acute renal failure
Legionella
Legionnaires' disease
Pneumonia
Rhabdomyolysis
Tofacitinib
Journal
Journal of community hospital internal medicine perspectives
ISSN: 2000-9666
Titre abrégé: J Community Hosp Intern Med Perspect
Pays: United States
ID NLM: 101601396
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
04
2021
revised:
28
12
2021
accepted:
07
01
2022
entrez:
17
6
2022
pubmed:
18
6
2022
medline:
18
6
2022
Statut:
epublish
Résumé
A 58-year-old female patient presented with altered mental status, diarrhea, and fever. She was hospitalized for acute kidney injury [AKI] and a patchy right lower lobe infiltrates on chest X-ray. Subsequent testing revealed rhabdomyolysis and a positive urinary Legionella antigen test. Creatinine kinase [CK] level peaked at 512,820 U/L and was managed with aggressive intravenous hydration and appropriate antibiotic treatment. With clinical signs of resolution of pneumonia, the CK level declined rapidly, however renal function returned to baseline only after 2 months requiring hemodialysis in the meantime. The patient was also on tofacitinib which can rarely contribute to rhabdomyolysis. Legionella infection can cause severe rhabdomyolysis and AKI. Timely diagnosis of Legionella-associated rhabdomyolysis, and prompt treatment with aggressive IV hydration and appropriate antibiotics is required to prevent morbidity and mortality.
Identifiants
pubmed: 35712689
doi: 10.55729/2000-9666.1038
pii: jchimp-12-02-045
pmc: PMC9195066
doi:
Types de publication
Case Reports
Langues
eng
Pagination
45-49Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 Greater Baltimore Medical Center.
Déclaration de conflit d'intérêts
Conflict of interest No conflict of interest.
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