Aggressive behaviour in antipsychotic-naive first-episode schizophrenia patients, their unaffected siblings and healthy controls.
aggression
early psychosis
first-episode schizophrenia
siblings
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
17
04
2022
received:
28
07
2021
accepted:
29
05
2022
pubmed:
18
6
2022
medline:
22
3
2023
entrez:
17
6
2022
Statut:
ppublish
Résumé
While patients with schizophrenia are more likely to be victims rather than perpetrators of aggressive behaviour, prior research has shown increased rates of aggressive behaviours in these patients that appear very early in the course of illness. We aimed to assess aggression in antipsychotic-naive first-episode schizophrenia patients, their healthy siblings, and controls; and to investigate correlates of aggression in the patients group. Patients (N = 55), siblings (N = 55) and healthy controls (N = 71) were evaluated on Buss and Perry Aggression Questionnaire (AQ), Life History of Aggression (LHA), Barratt Impulsiveness Scale, and Levenson Self-Report Psychopathy Scale. Age, gender and substance use were regarded as covariates, and differences between the three groups were evaluated using analysis of covariance. Hierarchical regression was performed to determine which variables were associated with aggression level in the patients group. The Tukey multiple comparison test showed that both patients (p < .001) and siblings (p = .023) scored higher on the LHA Aggression than controls. Siblings scored higher than controls (p = .010) for the Anger subscale of the AQ. Patients scored significantly higher than controls in the three impulsiveness dimensions; whereas siblings scored higher than controls in the motor (p = .023) and non-planning (p = .004) dimensions. Multivariate analyses showed that, after controlling for confounders, only attentional impulsiveness (β = .446, p = .0244) and psychopathy traits (β = .359, p = .010) helped predict AQ total scores among patients. Aggression and some of its risk factors including impulsiveness are likely to be trait variables that might provide important vulnerability markers for people at heightened risk of developing psychosis.
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
299-310Informations de copyright
© 2022 John Wiley & Sons Australia, Ltd.
Références
Allen, J. J., & Anderson, C. A. (2017). Aggression and violence: Definitions and distinctions. In The Wiley handbook of violence and aggression (pp. 1-14). Wiley-Blackwell.
Alradaydeh, M. F., & Alorani, O. I. (2017). The relationship between aggression and perceived social support among university students in Jordan. International Journal of Humanities and Social Science, 7(1), 200-205.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed. Text revision ed.). Washington, DC.
Barry, A. B., Koeppel, J. A., & Ho, B. C. (2020). Impulsive decision making, brain cortical thickness and familial schizophrenia risk. Schizophrenia Research, 220, 54-60.
Ben Khelil, M., Gharbaoui, M., Farhani, F., Zaafrane, M., Harzallah, H., Allouche, M., Zhioua, M., & Hamdoun, M. (2016). Impact of the Tunisian revolution on homicide and suicide rates in Tunisia. International Journal of Public Health, 61(9), 995-1002.
Bhatia, T., Gettig, E. A., Gottesman, I. I., Berliner, J., Mishra, N. N., Nimgaonkar, V. L., & Deshpande, S. N. (2016). Stratifying empiric risk of schizophrenia among first degree relatives using multiple predictors in two independent Indian samples. Asian Journal of Psychiatry, 24, 79-84.
Bjørkly, S. (2013). A systematic review of the relationship between impulsivity and violence in persons with psychosis: Evidence or spin cycle? Aggression and Violent Behavior, 18, 753-760.
Blair, R., Bajaj, S., Sherer, N., Bashford-Largo, J., Zhang, R., Aloi, J., Hammond, C., Lukoff, J., Schwartz, A., Elowsky, J., Tyler, P., Filbey, F. M., Dobbertin, M., & Blair, K. S. (2021). Alcohol use disorder and cannabis use disorder symptomatology in adolescents and aggression: Associations with recruitment of neural regions implicated in retaliation. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, 6(5), 536-544.
Bushman, B. J., & Huesmann, L. R. (2010). Aggression. In S. T. Fiske, D. T. Gilbert, & G. Lindzey (Eds.), Handbook of social psychology (Vol. 2, 5th ed., pp. 833-863). John Wiley & Sons.
Caqueo-Urízar, A., Fond, G., Urzúa, A., Boyer, L., & Williams, D. R. (2016). Violent behavior and aggression in schizophrenia: Prevalence and risk factors. A multicentric study from three Latin-America countries. Schizophrenia Research, 178(1-3), 23-28.
Cho, W., Shin, W. S., An, I., Bang, M., Cho, D. Y., & Lee, S. H. (2019). Biological aspects of aggression and violence in schizophrenia. Clinical Psychopharmacology and Neuroscience: The Official Scientific Journal of the Korean College of Neuropsychopharmacology, 17(4), 475-486.
Coccaro, E. F., Berman, M. E., & Kavoussi, R. J. (1997). Assessment of life history of aggression: Development and psychometric characteristics. Psychiatry Research, 73, 147-157.
Coid, J. W., Ullrich, S., Kallis, C., Keers, R., Barker, D., Cowden, F., & Stamps, R. (2013). The relationship between delusions and violence: Findings from the East London first episode psychosis study. JAMA Psychiatry, 70(5), 465-471.
David, A. S. (1990). Insight and psychosis. British Journal of Psychiatry, 156, 798-808.
De Vries, B., van Busschbach, J. T., van der Stouwe, E., Aleman, A., van Dijk, J., Lysaker, P. H., Arends, J., Nijman, S. A., & Pijnenborg, G. (2019). Prevalence rate and risk factors of victimization in adult patients with a psychotic disorder: A systematic review and meta-analysis. Schizophrenia Bulletin, 45(1), 114-126.
DeWall, C. N., Anderson, C. A., & Bushman, B. J. (2012). Aggression. In H. Tennen, J. Suls, & I. B. Weiner (Eds.), Handbook of psychology (Vol. 5, 2nd ed., pp. 449-466). John Wiley & Sons.
Ekinci, O., & Ekinci, A. (2013). Association between insight, cognitive insight, positive symptoms and violence in patients with schizophrenia. Nordic Journal of Psychiatry, 67(2), 116-123.
Ellouze, F., Ghaffari, O., Zouari, O., Zouari, B., & M'rad, M. F. (2013). Validation de la version en arabe dialectal de l'échelle d'impulsivité de Barratt, la BIS-11. L'Encéphale, 39(1), 13-18.
Faay, M., & Sommer, I. E. (2021). Risk and prevention of aggression in patients with psychotic disorders. The American Journal of Psychiatry, 178(3), 218-220.
Fanning, J. R., Berman, M. E., Mohn, R. S., & McCloskey, M. S. (2011). Perceived threat mediates the relationship between psychosis proneness and aggressive behavior. Psychiatry Research, 186(2-3), 210-218.
Fazel, S., Långström, N., Hjern, A., Grann, M., & Lichtenstein, P. (2009). Schizophrenia, substance abuse, and violent crime. JAMA, 301(19), 2016-2023.
Fazel, S., Wolf, A., Palm, C., & Lichtenstein, P. (2014). Violent crime, suicide, and premature mortality in patients with schizophrenia and related disorders: A 38-year total population study in Sweden. The Lancet. Psychiatry, 1(1), 44-54.
Fekih-Romdhane, F., Cherif, W., & Cheour, M. (2020). Violence dans les états mentaux à ultra haut risque de psychose. Presse Medicale Formation, 1, 347-353.
Fekih-Romdhane, F., Ghrissi, F., Cherif, W., & Cheour, M. (2020). Impulsivité chez les sujets à ultra haut risque de psychose [Impulsivity in subjects at ultra high risk for psychosis]. L'Encephale, 46(6), 503-506.
Fekih-Romdhane, F., Nefzi, H., Sassi, H., Cherif, W., & Cheour, M. (2021). Sleep in first-episode schizophrenia patients, their unaffected siblings and healthy controls: A comparison. Early Intervention in Psychiatry, 15(5), 1167-1178.
Fekih-Romdhane, F., Skandrani, M., Dridi, A., Ridha, R., & Cheour, M. (2020). Homicide committed by individuals with severe mental illnesses: A comparative study before and after the Tunisian revolution of January 14th, 2011. International Journal of Law and Psychiatry, 71, 101580.
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured clinical interview for DSM-IV axis I disorders research version (SCID-I). New York, NY: Biometrics Research, New York State Psychiatric Institute.
Fleischman, A., Werbeloff, N., Yoffe, R., Davidson, M., & Weiser, M. (2014). Schizophrenia and violent crime: A population-based study. Psychological Medicine, 44(14), 3051-3057.
Fuertes-Saiz, A., Benito, A., Mateu, C., Carratalá, S., Almodóvar, I., Baquero, A., & Haro, G. (2019). Sensorimotor gating in cocaine-related disorder with comorbid schizophrenia or antisocial personality disorder. Journal of Dual Diagnosis, 15, 1-11.
Gil-Miravet, I., Fuertes-Saiz, A., Benito, A., Almodóvar, I., Ochoa, E., & Haro, G. (2021). Prepulse inhibition in cocaine addiction and dual pathologies. Brain Sciences, 11(2), 269.
Ho, B. C., Barry, A. B., & Koeppel, J. A. (2018). Impulsivity in unaffected adolescent biological relatives of schizophrenia patients. Journal of Psychiatric Research, 97, 47-53.
Hodgins, S. (2008). Violent behaviour among people with schizophrenia: A framework for investigations of causes, and effective treatment, and prevention. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 363(1503), 2505-2518.
Hoptman, M. J. (2015). Impulsivity and aggression in schizophrenia: A neural circuitry perspective with implications for treatment. CNS Spectrums, 20(3), 280-286.
Huber, C. G., Hochstrasser, L., Meister, K., Schimmelmann, B. G., & Lambert, M. (2016). Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder. Schizophrenia Research, 175(1-3), 198-203.
Huber, C. G., Smieskova, R., Schroeder, K., Studerus, E., Harrisberger, F., Aston, J., Walter, A., Walter, M., Riecher-Rössler, A., & Borgwardt, S. (2014). Evidence for an agitated-aggressive syndrome predating the onset of psychosis. Schizophrenia Research, 157(1-3), 26-32.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261-276.
Kemp, R., & David, A. (1997). Insight and compliance. In B. Blackwell (Ed.), Treatment compliance and the therapeutic alliance (pp. 61-84). Harwood Academic Publishers.
Keshavan, M. S., Diwadkar, V. A., Montrose, D. M., Stanley, J. A., & Pettegrew, J. W. (2004). Premorbid characterization in schizophrenia: The Pittsburgh high risk study. World Psychiatry, 3, 163-168.
Khalid, F. N., Ford, T., & Maughan, B. (2012). Aggressive behaviour and psychosis in a clinically referred child and adolescent sample. Social Psychiatry and Psychiatric Epidemiology, 47(11), 1795-1806.
Knezevic, V., Mitrovic, D., Drezgic-Vukic, S., Knezevic, J., Ivezic, A., Siladji-Mladenovic, D., & Golubovic, B. (2017). Prevalence and correlates of aggression and hostility in hospitalized schizophrenic patients. Journal of Interpersonal Violence, 32(2), 151-163.
Kudumija Slijepcevic, M., Jukic, V., Novalic, D., Zarkovic-Palijan, T., Milosevic, M., & Rosenzweig, I. (2014). Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. Croatian Medical Journal, 55(2), 156-162.
Lahera, G., Herrera, S., Reinares, M., Benito, A., Rullas, M., González-Cases, J., & Vieta, E. (2015). Hostile attributions in bipolar disorder and schizophrenia contribute to poor social functioning. Acta Psychiatrica Scandinavica, 131(6), 472-482.
Larsen, T. K., Johannessen, J. O., & Opjordsmoen, S. (1998). First-episode schizophrenia with long duration of untreated psychosis: Pathways to care. The British Journal of Psychiatry, 172(S33), 45-52.
Latalova, K., Kamaradova, D., & Prasko, J. (2014). Violent victimization of adult patients with severe mental illness: A systematic review. Neuropsychiatric Disease and Treatment, 10, 1925-1939.
Levenson, M. R., Kiehl, K. A., & Fitzpatrick, C. M. (1995). Assessing psychopathic attributes in a noninstitutionalized population. Journal of Personality and Social Psychology, 68(1), 151-158.
Lincoln, T. M., & Hodgins, S. (2008). Is lack of insight associated with physically aggressive behavior among people with schizophrenia living in the community? The Journal of Nervous and Mental Disease, 196(1), 62-66.
Lozzino, L., Ferrari, C., Large, M., Nielssen, O., & de Girolamo, G. (2015). Prevalence and risk factors of violence by psychiatric acute inpatients: A systematic review and metaanalysis. PLoS One, 10(6), e0128536.
McGrath, J., Welham, J., Scott, J., Varghese, D., Degenhardt, L., Alati, R., Williams, G. M., Bor, W., & Najman, J. M. (2010). Association between cannabis use and psychosis-related outcomes using sibling pair analysis in a cohort of young adults. Archives of General Psychiatry, 67(5), 440-447.
McGregor, K., Castle, D., & Dolan, M. (2012). Schizophrenia spectrum disorders, substance misuse, and the four-facet model of psychopathy: The relationship to violence. Schizophrenia Research, 136(1-3), 116-121.
Mlouki, I., Nouira, S., Hmaied, O., & El Mhamdi, S. (2020). Youth violence in maghreb countries. A systematic review. La Tunisie Medicale, 98(7), 527-536.
Morgan, K. D., Dazzan, P., Morgan, C., Lappin, J., Hutchinson, G., Suckling, J., Fearon, P., Jones, P. B., Leff, J., Murray, R. M., & David, A. S. (2010). Insight, grey matter and cognitive function in first-onset psychosis. The British Journal of Psychiatry: The Journal of Mental Science, 197(2), 141-148.
Moulin, V., Alameda, L., Framorando, D., Baumann, P. S., Gholam, M., Gasser, J., Do Cuenod, K. Q., & Conus, P. (2020). Early onset of cannabis use and violent behavior in psychosis. European Psychiatry: The Journal of the Association of European Psychiatrists, 63(1), e78.
Moulin, V., Golay, P., Palix, J., Baumann, P. S., Gholamrezaee, M. M., Azzola, A., Gasser, J., Do, K. Q., Alameda, L., & Conus, P. (2018). Impulsivity in early psychosis: A complex link with violent behaviour and a target for intervention. European Psychiatry: The Journal of the Association of European Psychiatrists, 49, 30-36.
Nakhli, J., Mlika, S., Bouhlel, S., Amamou, B., Chaieb, I., Ben Nasr, S., & Ben Hadj Ali, B. (2014). Translation into Arabic and validation of the schedule for the assessment of insight-expanded version (SAI-E) for use in Tunisia. Comprehensive Psychiatry, 55(4), 1050-1054.
Nielssen, O. B., Malhi, G. S., McGorry, P. D., & Large, M. M. (2012). Overview of violence to self and others during the first episode of psychosis. The Journal of Clinical Psychiatry, 73(5), e580-e587.
Oueslati, B., Fekih-Romdhane, F., Mrabet, A., & Ridha, R. (2018). Correlates of offense recidivism in patients with schizophrenia. International Journal of Law and Psychiatry, 58, 178-183.
Patton, J. H., Stanford, M. S., & Barratt, E. S. (1995). Factor structure of the Barratt impulsiveness scale. Journal of Clinical Psychology, 6, 768-774.
Raju, V., Grover, S., & Nehra, R. (2019). Social cognitions in siblings of patients with schizophrenia: A comparison with patients with schizophrenia and healthy controls - a cross-sectional study. Asian Journal of Psychiatry, 43, 24-33.
Reidy, D. E., Kearns, M. C., & DeGue, S. (2013). Reducing psychopathic violence: A review of the treatment literature. Aggression and Violent Behavior, 18(5), 527-538.
Rejeb, M. B., Daldoul, M., Ben Cheikh, A., Tabka, F., Ayachi, S., & Khochtali, H. (2022). Facial fractures in post-revolution Tunisia as violence indicator: About 476 cases. Annales de chirurgie plastique et esthetique, 67(1), 14-19.
Rund, B. R. (2018). A review of factors associated with severe violence in schizophrenia. Nordic Journal of Psychiatry, 72(8), 561-571.
Rutherford, C., Costa, D., Mercieca-Bebber, R., Rice, H., Gabb, L., & King, M. (2016). Mode of administration does not cause bias in patient-reported outcome results: A meta-analysis. Quality of Life Research: an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 25(3), 559-574.
Schwartz, J. A., Said Al-Ghamdi, M., Nezar Kobeisy, A., Alqurashi, F. H., Connolly, E. J., & Beaver, K. M. (2017). Internalizing and externalizing problems and parenting: Results from a Saudi Arabian sample. International Journal of Social Welfare, 26(3), 263-275.
Seeman, N., Tang, S., Brown, A. D., & Ing, A. (2016). World survey of mental illness stigma. Journal of Affective Disorders, 190, 115-121.
Spidel, A., Lecomte, T., Greaves, C., Sahlstrom, K., & Yuille, J. C. (2010). Early psychosis and aggression: Predictors and prevalence of violent behaviour amongst individuals with early onset psychosis. International Journal of Law and Psychiatry, 33(3), 171-176.
Starling, J., Williams, L. M., Hainsworth, C., & Harris, A. W. (2013). The presentation of early-onset psychotic disorders. The Australian and New Zealand Journal of Psychiatry, 47(1), 43-50.
Stuart, H. L., & Arboleda-Flórez, J. E. (2001). A public health perspective on violent offenses among persons with mental illness. Psychiatric Services (Washington, D.C.), 52(5), 654-659.
Swanson, J. W., Swartz, M. S., Van Dorn, R. A., Elbogen, E. B., Wagner, H. R., Rosenheck, R. A., Stroup, T. S., McEvoy, J. P., & Lieberman, J. A. (2006). A national study of violent behavior in persons with schizophrenia. Archives of General Psychiatry, 63(5), 490-499.
Tengström, A., Hodgins, S., & Kullgren, G. (2001). Men with schizophrenia who behave violently: The usefulness of an early- versus late-start offender typology. Schizophrenia Bulletin, 27(2), 205-218.
Torrey, E. F. (2011). Stigma and violence: Isn't it time to connect the dots? Schizophrenia Bulletin, 37(5), 892-896.
Varma, S. L., & Sharma, I. (1993). Psychiatric morbidity in the first-degree relatives of schizophrenic patients. The British Journal of Psychiatry: The Journal of Mental Science, 162, 672-678.
Volavka, J. (2014). Comorbid personality disorders and violent behavior in psychotic patients. The Psychiatric Quarterly, 85(1), 65-78.
Volavka, J. (2016). Triggering violence in psychosis. JAMA Psychiatry, 73(8), 769-770.
Volavka, J., & Citrome, L. (2011). Pathways to aggression in schizophrenia affect results of treatment. Schizophrenia Bulletin, 37(5), 921-929.
Whiting, D., Lennox, B. R., & Fazel, S. (2020). Violent outcomes in first-episode psychosis: A clinical cohort study. Early Intervention in Psychiatry, 14(3), 379-382.
Witt, K., van Dorn, R., & Fazel, S. (2013). Risk factors for violence in psychosis: Systematic review and meta-regression analysis of 110 studies. PLoS One, 8(2), e55942.
Word Health Organization. (2014). Global status report on violence prevention. World Health Organization.
Zouini, M., Senhaji, M., & Kerekes, N. (2019). Self-reported aggressive and antisocial behaviors in Moroccan high school students. Psihologija, 52(3), 235-247. https://doi.org/10.2298/PSI181225001Z