Tetrazole: A privileged scaffold for the discovery of anticancer agents.
carcinogenic factors
cellular proliferation
heterocyclic
resistance
synthesis
tetrazole
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
02
06
2022
received:
11
02
2022
accepted:
12
06
2022
pubmed:
18
6
2022
medline:
12
8
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
Carcinoma, characterized by abnormal growth of cells and tissue, is a ubiquitously leading cause of mortality across the globe due to some carcinogenic factors. Currently, several anticancer agents are commercially available in the global market. However, due to their resistance and cost, researchers are gaining more interest in developing newer novel potential anticancer agents. In the search for new drugs for clinical use, the tetrazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules. Among the various heterocyclic agents, tetrazole-containing compounds have shown significant promise in the treatment of a wide range of diseases, particularly cancer. Here, in this review, we focused on several synthetic approaches for the synthesis of tetrazole analogs, their targets for treating cancer along with the biological activity of some of the recently reported tetrazole-containing anticancer agents.
Substances chimiques
Antineoplastic Agents
0
Tetrazoles
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
419-442Informations de copyright
© 2022 John Wiley & Sons Ltd.
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