COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study.
COVID-19
adverse reaction
autoimmune disease
rheumatic disease
vaccine
Journal
Rheumatology (Oxford, England)
ISSN: 1462-0332
Titre abrégé: Rheumatology (Oxford)
Pays: England
ID NLM: 100883501
Informations de publication
Date de publication:
23 12 2022
23 12 2022
Historique:
received:
14
01
2022
revised:
14
04
2022
pubmed:
18
6
2022
medline:
28
12
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination-related adverse events (AEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed in the COVAD study, a patient self-reported cross-sectional survey. The survey was circulated in early 2021 by >110 collaborators (94 countries) to collect SAID details, COVID-19 vaccination details and 7-day vaccine AEs, irrespective of respondent vaccination status. Analysis was performed based on data distribution and variable type. Ten thousand nine hundred respondents [median (interquartile range) age 42 (30-55) years, 74% females and 45% Caucasians] were analysed; 5867 patients (54%) with SAIDs were compared with 5033 HCs. Seventy-nine percent had minor and only 3% had major vaccine AEs requiring urgent medical attention (but not hospital admission) overall. Headache [SAIDs = 26%, HCs = 24%; odds ratio (OR) = 1.1 (95% CI: 1.03, 1.3); P = 0.014], abdominal pain [SAIDs = 2.6%, HCs = 1.4%; OR = 1.5 (95% CI: 1.1, 2.3); P = 0.011], and dizziness [SAIDs = 6%, HCs = 4%; OR = 1.3 (95% CI: 1.07, 1.6); P = 0.011], were slightly more frequent in SAIDs. Overall, major AEs [SAIDs = 4%, HCs = 2%; OR = 1.9 (95% CI: 1.6, 2.2); P < 0.001] and, specifically, throat closure [SAIDs = 0.5%, HCs = 0.3%; OR = 5.7 (95% CI: 2.9, 11); P = 0.010] were more frequent in SAIDs though absolute risk was small (0-4%). Major AEs and hospitalizations (<2%) were comparable across vaccine types in SAIDs. Vaccination against COVID-19 is safe in SAID patients. SAIDs were at a higher risk of major AEs than HCs, though absolute risk was small. There are small differences in minor AEs between vaccine types in SAID patients.
Identifiants
pubmed: 35713499
pii: 6609762
doi: 10.1093/rheumatology/keac305
pmc: PMC9214139
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-76Subventions
Organisme : Versus Arthritis
ID : 21992
Pays : United Kingdom
Investigateurs
Mrudula Joshi
(M)
Bhupen Barman
(B)
Yogesh Preet Singh
(YP)
Rajiv Ranjan
(R)
Avinash Jain
(A)
Sapan C Pandya
(SC)
Rakesh Kumar Pilania
(RK)
Aman Sharma
(A)
M Manesh Manoj
(M)
Vikas Gupta
(V)
Chengappa G Kavadichanda
(CG)
Pradeepta Sekhar Patro
(PS)
Sajal Ajmani
(S)
Sanat Phatak
(S)
Rudra Prosad Goswami
(RP)
Abhra Chandra Chowdhury
(AC)
Ashish Jacob Mathew
(AJ)
Padnamabha Shenoy
(P)
Ajay Asranna
(A)
Keerthi Talari Bommakanti
(KT)
Anuj Shukla
(A)
ArunKumar R Pandey
(AR)
Kunal Chandwar
(K)
Döndü Üsküdar Cansu
(DÜ)
John D Pauling
(JD)
Chris Wincup
(C)
Ashima Makol
(A)
Nicoletta Del Papa
(N)
Gianluca Sambataro
(G)
Atzeni Fabiola
(A)
Marcello Govoni
(M)
Simone Parisi
(S)
Elena Bartoloni Bocci
(EB)
Gian Domenico Sebastiani
(GD)
Enrico Fusaro
(E)
Marco Sebastiani
(M)
Luca Quartuccio
(L)
Franco Franceschini
(F)
Pier Paolo Sainaghi
(PP)
Giovanni Orsolini
(G)
Rossella De Angelis
(R)
Maria Giovanna Danielli
(MG)
Vincenzo Venerito
(V)
Lisa S Traboco
(LS)
Suryo Anggoro Kusumo Wibowo
(SAK)
Jorge Rojas Serrano
(JR)
Ignacio García-De La Torre
(I)
Erick Adrian Zamora Tehozol Jesús Loarce-Martos
(EAZTJ)
Sergio Prieto-González
(S)
Albert Gil-Vila
(A)
Raquel Aranega
(R)
Ran Nakashima
(R)
Shinji Sato
(S)
Naoki Kimura
(N)
Yuko Kaneko
(Y)
Stylianos Tomaras
(S)
Margarita Aleksandrovna Gromova
(MA)
Or Aharonov
(O)
Ihsane Hmamouchi
(I)
Leonardo Santos Hoff
(LS)
Margherita Giannini
(M)
François Maurier
(F)
Julien Campagne
(J)
Alain Meyer
(A)
Melinda Nagy-Vincze
(M)
Daman Langguth
(D)
Vidya Limaye
(V)
Merrilee Needham
(M)
Nilesh Srivastav
(N)
Marie Hudson
(M)
Océane Landon-Cardinal
(O)
Syahrul Sazliyana Shaharir
(SS)
Wilmer Gerardo Rojas Zuleta
(WGR)
José António Pereira Silva
(JAP)
João Eurico Fonseca
(JE)
Olena Zimba
(O)
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.