Inhibitory Effects of Cold Atmospheric Plasma on Inflammation and Tumor-Like Feature of Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis.
MMP-3
RANKL.
apoptosis
cold atmospheric plasma
fibroblast-like synoviocytes
inflammation
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
04
04
2022
accepted:
07
06
2022
revised:
03
06
2022
pubmed:
18
6
2022
medline:
15
11
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is a chronic, debilitating systemic disease characterized by chronic inflammation and progressive joint destruction. Fibroblast-like synoviocytes (FLSs) are one of the most important players in the pathophysiology of RA, acting like tumor cells and secreting inflammatory cytokines. Previous research has shown that cold atmospheric plasma (CAP) inhibits cancer cells and may have anti-inflammatory properties. This study examined the effects of argon plasma jet-produced CAP on the suppression of invasion and inflammation caused by cultured RA-FLS. The findings revealed that CAP reduced cell viability and elevated the percentage of apoptotic RA-FLS by producing reactive oxygen species. Carboxyfluorescein diacetate succinimidyl ester (CFSE) staining confirmed that CAP could decrease the proliferation of RA-FLS. Furthermore, CAP effectively reduced the production of inflammatory factors (e.g., NF-κB and IL-6) as well as destructive factors like receptor activator of nuclear factor kappa-B ligand (RANKL) and matrix metalloproteinases-3 (MMP-3). These data suggest that CAP could be a promising treatment for slowing the progression of RA by reducing tumor-like features and inflammation in RA-FLS.
Identifiants
pubmed: 35713788
doi: 10.1007/s10753-022-01703-3
pii: 10.1007/s10753-022-01703-3
doi:
Substances chimiques
Plasma Gases
0
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2433-2448Subventions
Organisme : Mazandaran University of Medical Sciences
ID : MAZUMS
Organisme : Mazandaran University of Medical Sciences
ID : IR.MAZUMS.REC.1398.6891
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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