Chemical constituents of Entandrophragma angolense and their anti-inflammatory activity.

Anti-Inflammatory Agents / pharmacology Catechin Limonins / chemistry Meliaceae / chemistry Molecular Structure
Anti-inflammation Catechin Entandrophragma angolense Limonoid Meliaceae Nitric oxide inhibition Seco-tirucallane

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 24 01 2022
revised: 10 06 2022
accepted: 11 06 2022
pubmed: 18 6 2022
medline: 27 7 2022
entrez: 17 6 2022
Statut: ppublish

Résumé

From the stem bark of Entandrophragma angolense, six undescribed compounds were isolated, including seco-tirucallane type triterpenoids, limonoids, and a catechin glucoside, along with nineteen known structures. All structures were determined by interpretation of spectroscopic and HRMS data, and absolute configuration was confirmed with the aid of electronic circular dichroism. The isolated compounds were tested for LPS-induced NO inhibition in RAW 264.7 macrophages and EC

Identifiants

DOI: 10.1016/j.phytochem.2022.113276 PMID: 35714737
pubmed: 35714737
pii: S0031-9422(22)00192-3
doi: 10.1016/j.phytochem.2022.113276
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Limonins 0
Catechin 8R1V1STN48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113276

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Isoo Youn (I)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Kyu-Yeon Han (KY)

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Aleksandra Gurgul (A)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Zhenlong Wu (Z)

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.

Hyun Lee (H)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States; Biophysics Core at Research Resource Center, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Chun-Tao Che (CT)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States. Electronic address: chect@uic.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Chemical constituents of Entandrophragma...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Catéchine › Chemical constituents of Entandrophragma...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Limonines › Chemical constituents of Entandrophragma...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Meliaceae › Chemical constituents of Entandrophragma...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Chemical constituents of Entandrophragma...