The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer.


Journal

NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166

Informations de publication

Date de publication:
17 Jun 2022
Historique:
received: 20 10 2021
accepted: 17 05 2022
entrez: 17 6 2022
pubmed: 18 6 2022
medline: 18 6 2022
Statut: epublish

Résumé

Carriers of germline BRCA2 pathogenic sequence variants have elevated aggressive prostate cancer risk and are candidates for precision oncology treatments. We examined whether BRCA2-deficient (BRCA2

Identifiants

pubmed: 35715489
doi: 10.1038/s41698-022-00284-6
pii: 10.1038/s41698-022-00284-6
pmc: PMC9205939
doi:

Types de publication

Journal Article

Langues

eng

Pagination

39

Subventions

Organisme : NCI NIH HHS
ID : R00 CA245900
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : R00-CA245900
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : R01-CA207365

Informations de copyright

© 2022. The Author(s).

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Auteurs

Kevin H Kensler (KH)

Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.

Shakuntala Baichoo (S)

Department of Digital Technologies, FoICDT, University of Mauritius, Réduit, Mauritius.

Shailja Pathania (S)

Center for Personalized Cancer Therapy, University of Massachusetts, Boston, MA, USA.
Department of Biology, University of Massachusetts, Boston, MA, USA.

Timothy R Rebbeck (TR)

Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. timothy_rebbeck@dfci.harvard.edu.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. timothy_rebbeck@dfci.harvard.edu.

Classifications MeSH