Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 06 2022
17 06 2022
Historique:
received:
08
04
2022
accepted:
08
06
2022
entrez:
17
6
2022
pubmed:
18
6
2022
medline:
22
6
2022
Statut:
epublish
Résumé
Premature ventricular contractions (PVCs) during recovery of exercise stress testing are associated with increased cardiovascular mortality, but the cause remains unknown. We aimed to evaluate the association of PVCs during recovery with echocardiographic abnormalities, and their combined prognostic performance. Echocardiographic abnormalities [reduced left ventricular (LV) ejection fraction, valvular heart disease, LV dilatation, LV hypertrophy, or increased filling pressures] and PVCs during recovery were identified among patients having undergone both echocardiography and exercise stress test. Among included patients (n = 3106, age 59 ± 16 years, 55% males), PVCs during recovery were found in 1327 (43%) patients, among which the prevalence of echocardiographic abnormalities was increased (58% vs. 43%, p < 0.001). Overall, PVCs during recovery were associated with increased cardiovascular mortality (219 total events, 7.9 [5.4-11.1] years follow-up; adjusted hazard ratio (HR [95% confidence interval]) 1.6 [1.2-2.1], p < 0.001). When analyzed in combination with either presence or absence of echocardiographic abnormalities, PVCs during recovery were associated with increased risk when such were present (HR 3.3 [1.9-5.5], p < 0.001) but not when absent (HR 1.5 [0.8-2.8], p = 0.22), in reference to those with neither. Our findings provide mechanistic insights to the increased CV risk reported in patients with PVCs during recovery.
Identifiants
pubmed: 35715698
doi: 10.1038/s41598-022-14535-w
pii: 10.1038/s41598-022-14535-w
pmc: PMC9205997
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10265Informations de copyright
© 2022. The Author(s).
Références
J Hypertens. 2022 Feb 1;40(2):300-309
pubmed: 34475344
Am Heart J. 2003 Jan;145(1):139-46
pubmed: 12514666
Circ Res. 2017 Sep 15;121(7):784-802
pubmed: 28912183
J Am Coll Cardiol. 2021 Dec 7;78(23):2278-2280
pubmed: 34857088
Clin Physiol Funct Imaging. 2014 Jul;34(4):297-307
pubmed: 24171936
Medicine (Baltimore). 2018 Jul;97(28):e11489
pubmed: 29995813
J Am Coll Cardiol. 2015 Jul 14;66(2):101-9
pubmed: 26160626
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70
pubmed: 25712077
Trends Cardiovasc Med. 2003 Nov;13(8):316-22
pubmed: 14596946
Ann Med. 2019 Nov - Dec;51(7-8):390-396
pubmed: 31638839
JAMA. 2003 Sep 24;290(12):1600-7
pubmed: 14506119
N Engl J Med. 2003 Feb 27;348(9):781-90
pubmed: 12606732
N Engl J Med. 2000 Sep 21;343(12):826-33
pubmed: 10995861
Am J Cardiol. 1987 Jun 1;59(15):1251-5
pubmed: 3591677
Scand J Public Health. 2013 Dec;41(8):883-9
pubmed: 23982462
Eur Heart J. 2017 Sep 21;38(36):2739-2791
pubmed: 28886619
Eur J Prev Cardiol. 2021 Oct 13;28(12):1360-1369
pubmed: 34647584
J Am Coll Cardiol. 2004 Aug 18;44(4):820-6
pubmed: 15312865
Arch Intern Med. 2008 Jan 28;168(2):225-34
pubmed: 18227372
Am J Cardiol. 2016 Sep 1;118(5):725-32
pubmed: 27394411
Circulation. 1984 Feb;69(2):250-8
pubmed: 6690098
Clin Cardiol. 2019 Dec;42(12):1162-1169
pubmed: 31571249
J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S1-7
pubmed: 17993305
N Engl J Med. 1999 Oct 28;341(18):1351-7
pubmed: 10536127
Eur J Epidemiol. 2017 Sep;32(9):765-773
pubmed: 28983736
Heart Asia. 2017 Jan 4;9(1):14-24
pubmed: 28123456
Biol Res Nurs. 2020 Jul;22(3):369-377
pubmed: 32342704
Ann Noninvasive Electrocardiol. 2005 Jan;10(1):47-52
pubmed: 15649237
J Am Coll Cardiol. 2021 Dec 7;78(23):2267-2277
pubmed: 34857087
Clin Physiol Funct Imaging. 2020 Mar;40(2):83-90
pubmed: 31697026
Circulation. 2004 May 25;109(20):2417-22
pubmed: 15148273
Clin Physiol Funct Imaging. 2021 May;41(3):281-291
pubmed: 33583090