Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin.
Ectoin
Polymorphous light eruption
Sunscreen
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
18
03
2022
accepted:
01
06
2022
pubmed:
19
6
2022
medline:
19
6
2022
entrez:
18
6
2022
Statut:
ppublish
Résumé
Polymorphic light eruption (PLE) is the most common idiopathic, acquired photodermatosis. The pathophysiology of PLE is not yet fully understood but seems to involve immunological mechanisms, UVA-induced oxidative stress, and the subsequent elicitation of a cellular stress response affecting keratinocyte gene expression and skin immune function. In the present study, a high broad-spectrum sunscreen medical device (MD), containing a very high protection complex of UVB and UVA filters and ectoin, was investigated for its ability to protect against UVA-induced PLE. The study was carried out as a monocentric, double-blinded, randomized, untreated controlled design. The test MD was applied (2 mg/cm Overall, no positive PLE reaction was observed on the side of the chest treated by the test MD, whereas positive PLE reactions were triggered on the untreated side of 13 subjects. Subjective sensations were very rare on the MD-treated side but were numerous and more severe on the untreated side. Chromametry and clinical visual inspection indicated that the skin color was unchanged on the MD-protected side, whereas high increased values of erythema and pigmentation were observed on the untreated chest side. This MD sunscreen based on a complex of UVA-UVB filters and 1% of ectoin may be effective in preventing UVA-induced PLE. New studies comparing this MD sunscreen versus the same product without ectoin should be conducted. gov identifier: NCT05320315 (retrospectively registered 09/17/2021).
Identifiants
pubmed: 35716331
doi: 10.1007/s13555-022-00755-5
pii: 10.1007/s13555-022-00755-5
pmc: PMC9276854
doi:
Banques de données
ClinicalTrials.gov
['NCT05320315']
Types de publication
Journal Article
Langues
eng
Pagination
1603-1613Informations de copyright
© 2022. The Author(s).
Références
Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinical aspects and pathogenesis. Dermatol Clin. 2014;32:315–34.
doi: 10.1016/j.det.2014.03.012
Stephansson E, Ros AM. Expression of intercellular adhesion molecule-1 (ICAM-1) and OKM5 in UVA- and UVB-induced lesions in patients with lupus erythematosus and polymorphous light eruption. Arch Dermatol Res. 1993;285(6):328–33. https://doi.org/10.1007/BF00371832 .
doi: 10.1007/BF00371832
pubmed: 7692827
Hölzle E, Plewig G, von Kries R, et al. Polymorphous light eruption. J Invest Dermatol. 1987;88(3 Suppl):32s–8s.
doi: 10.1038/jid.1987.7
Hasan T, Ranki A, Jansen CT, et al. Disease associations in polymorphous light eruption. A long-term follow-up study of 94 patients. Arch Dermatol. 1998;134:1081–5.
doi: 10.1001/archderm.134.9.1081
Bissonnette R, Nigen S, Bolduc C. Influence of the quantity of sunscreen applied on the ability to protect against ultraviolet-induced polymorphous light eruption. Photodermatol Photoimmunol Photomed. 2012;28:240–3.
doi: 10.1111/j.1600-0781.2012.00678.x
Gozali MV, Zhou B, Luo D. Update on treatment of photodermatosis. Dermatol Online J. 2016;22:2.
doi: 10.5070/D3222030080
Schleyer V, Weber O, Yazdi A, Benedix F, Dietz K, Röcken M, Berneburg M. Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions. Acta Derm Venereol. 2008;88(6):555–60.
pubmed: 19002338
Schaefer H, Moyal D, Fourtanier A. State of the art sunscreens for prevention of photodermatoses. J Dermatol Sci. 2000;23(1):S62–74.
doi: 10.1016/S0923-1811(99)00068-7
Ahmed RS, Suke SG, Seth V, Jain A, Bhattacharya SN, Banerjee BD. Impact of oral vitamin E supplementation on oxidative stress & lipid peroxidation in patients with polymorphous light eruption. Indian J Med Res. 2006;2016:8.
Hadshiew IM, Treder-Conrad CV, Bülow R, Klette E, Mann T, Stäb F, et al. Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis. Photodermatol Photoimmunol Photomed. 2004;20(4):200–4.
doi: 10.1111/j.1600-0781.2004.00103.x
Rippke F, Wendt G, Bohnsack K, Dörschner A, Stäb F, Hölzle E, et al. Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption. J Dermatol Treat. 2001;12(1):3–8.
doi: 10.1080/095466301750163491
Buenger J, Driller H. Ectoin: an effective natural substance to prevent UVA-induced premature photoaging. Skin Pharmacol Physio. 2004;17:232–7.
doi: 10.1159/000080216
Grether-Beck S, Bonizzi G, Schmitt-Brenden H, Felsner I, Timmer A, Sies H, Johnson JP, Piette J, Krutmann J. Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J. 2000;19(21):5793–800. https://doi.org/10.1093/emboj/19.21.5793 .
doi: 10.1093/emboj/19.21.5793
pubmed: 11060030
pmcid: 305810
Grether-Beck S, Salahshour-Fard M, Timmer A, Brenden H, Felsner I, Walli R, Füllekrug J, Krutmann J. Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression. Oncogene. 2008;27(35):4768–78. https://doi.org/10.1038/onc.2008.116 .
doi: 10.1038/onc.2008.116
pubmed: 18438433
Grether-Beck S, Timmer A, Felsner I, Brenden H, Brammertz D, Krutmann J. Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J Invest Dermatol. 2005;125(3):545–53. https://doi.org/10.1111/j.0022-202X.2005.23782.x .
doi: 10.1111/j.0022-202X.2005.23782.x
pubmed: 16117797
Bünger J, Degwert J, Driller H. The protective function of compatible solute ectoin on the skin, skin cells and its biomolecules with respect to UV-radiation, immunosuppression and membrane damage. IFSCC-Magazine. 2001;4:2.
Phan NQ, Blome C, Fritz F, et al. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2012;92(5):502–7. https://doi.org/10.2340/00015555-1246 .
doi: 10.2340/00015555-1246
pubmed: 22170091
Duteil L, Esdaile J, Maubert Y, Cathelineau AC, Bouloc A, Queille-Roussel C, Passeron T. A method to assess the protective efficacy of sunscreens against visible light-induced pigmentation. Photodermatol Photoimmunol Photomed. 2017;33(5):260–6. https://doi.org/10.1111/phpp.12325 .
doi: 10.1111/phpp.12325
pubmed: 28602025
Chardon A, Crétois I, Hourseau C. Skin colour typology and suntanning pathways. Int J Cosm Scien. 1991;125:191–208.
doi: 10.1111/j.1467-2494.1991.tb00561.x
Ling TC, Richards HL, Jansen AS, et al. Seasonal and latitudinal impact of polymorphic light eruption on quality of life. J Invest Dermatol. 2006;126(7):1648–51. https://doi.org/10.1038/sj.jid.5700306 .
doi: 10.1038/sj.jid.5700306
pubmed: 16614724
Richards HL, Ling TC, Evangelou G. Psychologic distress in polymorphous light eruption and its relationship to patients’ beliefs about their condition. J Am Acad Dermatol. 2007;56(3):426–31. https://doi.org/10.1016/j.jaad.2006.10.035 .
doi: 10.1016/j.jaad.2006.10.035
pubmed: 17184877
Richards HL, Ling TC, Evangelou G. Evidence of high levels of anxiety and depression in polymorphic light eruption and their association with clinical and demographic variables. Br J Dermatol. 2008;159(2):439–44.
doi: 10.1111/j.1365-2133.2008.08623.x
Rizwan M, Haylett AK, Richards HL. Impact of photosensitivity disorders on the life quality of children. Photodermol Photoimmunol Photomed. 2012;28(6):290–2.
doi: 10.1111/j.1600-0781.2012.00691.x
Allas S, Lui H, Moyal D, Bissonnette R. Comparison of the ability of 2 sunscreens to protect against polymorphous light eruption induced by a UV-A/UV-B metal halide lamp. Arch Dermatol. 1999;135(11):1421–2. https://doi.org/10.1001/archderm.135.11.1421 .
doi: 10.1001/archderm.135.11.1421
pubmed: 10566855
Jeanmougin M, Peyron JL, Thomas P. Polymorphic light eruption: prophylaxis using a topical combination of antioxidants and UVA protection formulation. Ann Dermatol Venereol. 2006;133(5 Pt 1):425–8. https://doi.org/10.1016/s0151-9638(06)70932-2 .
doi: 10.1016/s0151-9638(06)70932-2
pubmed: 16760827
Rippke F, Wendt G, Bohnsack K, et al. Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption. J Dermatolog Treat. 2001;12(1):3–8. https://doi.org/10.1080/095466301750163491 .
doi: 10.1080/095466301750163491
pubmed: 12171679
Hadshiew I, Stäb F, Untiedt S, Bohnsack K, et al. Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption. Dermatology. 1997;195(4):362–8. https://doi.org/10.1159/000245989 .
doi: 10.1159/000245989
pubmed: 9529558
Schleyer V, Weber O, Yazdi A, et al. Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions. Acta Derm Venereol. 2008;88(6):555–60. https://doi.org/10.2340/00015555-0509 .
doi: 10.2340/00015555-0509
pubmed: 19002338
Fourtanier A, Moyal D, Seité S. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed. 2008;24(4):164–74. https://doi.org/10.1111/j.1600-0781.2008.00365.x .
doi: 10.1111/j.1600-0781.2008.00365.x
pubmed: 18717957
Guarrera M. Polymorphous light eruption. Adv Exp Med Biol. 2017;996:61–70. https://doi.org/10.1007/978-3-319-56017-5_6 .
doi: 10.1007/978-3-319-56017-5_6
pubmed: 29124691
Galinski EA. Compatible solutes of halophilic eubacteria: molecular principles, water-solute interaction, stress protection. Experienta. 1993;49:487–96.
doi: 10.1007/BF01955150
Botta C, Di Giorgio C, Sabatier AS, et al. Genotoxicity of visible light (400–800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens. J Photochem Photobiol B. 2008;91(1):24–34. https://doi.org/10.1016/j.jphotobiol.2008.01.008 .
doi: 10.1016/j.jphotobiol.2008.01.008
pubmed: 18325778
Bownik A, Stępniewska Z. Ectoine as a promising protective agent in humans and animals. Arh Hig Rada Toksikol. 2016;67(4):260–5. https://doi.org/10.1515/aiht-2016-67-2837 .
doi: 10.1515/aiht-2016-67-2837
pubmed: 28033102