T-cell Immunotherapy and Cardiovascular Disease: Chimeric Antigen Receptor T-cell and Bispecific T-cell Engager Therapies.

Cardiotoxicity Cardiovascular Diseases / therapy Humans Immunotherapy Receptors, Chimeric Antigen / therapeutic use T-Lymphocytes
Bispecific T-cell engager (BiTE) therapy Cardio-Oncology Cardiotoxicity Chimeric Antigen Receptor (CAR) T-cell therapy Immunotherapy

Journal

Heart failure clinics
ISSN: 1551-7136
Titre abrégé: Heart Fail Clin
Pays: United States
ID NLM: 101231934

Informations de publication

Date de publication:
Jul 2022
Historique:
entrez: 19 6 2022
pubmed: 20 6 2022
medline: 22 6 2022
Statut: ppublish

Résumé

Chimeric antigen receptor (CAR) T-cell and bispecific T-cell engager (BiTE) therapies have revolutionized the treatment of refractory or relapsed leukemia and lymphoma. Increased use of these therapies has revealed signals of significant cardiotoxicity, including cardiomyopathy/heart failure, arrhythmia, myocardial injury, hemodynamic instability, and cardiovascular death mainly in the context of a profound inflammatory response to CAR T-cell antitumor effects known as cytokine release syndrome (CRS). Preexisting cardiovascular risk factors and disease may increase the risk of such cardiotoxicity. High index of suspicion and close monitoring is required for prompt recognition. Supportive hemodynamic care and targeted anti-IL-6 therapy, as well as possibly broader immunosuppression with corticosteroids, are the cornerstones of the management.

Identifiants

DOI: 10.1016/j.hfc.2022.02.008 PMID: 35718418
pubmed: 35718418
pii: S1551-7136(22)00009-5
doi: 10.1016/j.hfc.2022.02.008
pii:
doi:

Substances chimiques

Receptors, Chimeric Antigen 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

443-454

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ashley F Stein-Merlob (AF)

Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; Division of Cardiology, Department of Medicine, UCLA-Cardio-Oncology Program, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address: https://twitter.com/A_SteinMerlob.

Sarju Ganatra (S)

Cardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA. Electronic address: sarju.ganatra@lahey.org.

Eric H Yang (EH)

Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; Division of Cardiology, Department of Medicine, UCLA-Cardio-Oncology Program, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address: ehyang@mednet.ucla.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Rayonnement › Cardiotoxicité › T-cell Immunotherapy and Cardiovascular...
questionsmedicales.fr › Maladies cardiovasculaires › T-cell Immunotherapy and Cardiovascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T-cell Immunotherapy and Cardiovascular...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › T-cell Immunotherapy and Cardiovascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › T-cell Immunotherapy and Cardiovascular...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › T-cell Immunotherapy and Cardiovascular...