Comparison of two formulations of alfaxalone for immersion anaesthesia in laboratory zebrafish (Daniorerio).
alfaxalone
alfaxan
immersion anaesthesia
zebrafish
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
10
01
2022
revised:
05
04
2022
accepted:
04
05
2022
pubmed:
20
6
2022
medline:
28
9
2022
entrez:
19
6
2022
Statut:
ppublish
Résumé
To compare two commercial formulations of alfaxalone for immersion anaesthesia in laboratory zebrafish. Prospective, blinded, randomized study. A total of 20 adult Danio rerio (Tuebingen strain). Zebrafish were divided into two groups of 10 (five female, five male) and placed in individual immersion baths containing 10 mg L There were no statistical differences between groups in reported variables. TPT, AIT and ART were 10.2 ± 1.2, 1.9 ± 0.9 and 8.3 ± 1.2 minutes for group 1 and 10.8 ± 2.9, 2.4 ± 1.2 and 8.4 ± 2.7 minutes for group 2. No gross external pathology was evident, and no fish died during the experimental period. Histopathology showed normal gill pathology and no difference between the groups. Immersion anaesthesia using 10 mg L
Identifiants
pubmed: 35718716
pii: S1467-2987(22)00074-5
doi: 10.1016/j.vaa.2022.05.001
pii:
doi:
Substances chimiques
Anesthetics
0
Pregnanediones
0
Water
059QF0KO0R
alphaxalone
BD07M97B2A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-476Informations de copyright
Copyright © 2022 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.