Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS).
asphyxia
contact angle
inhalation
physical obstruction
rat
suffocation
synthetic amorphous silica
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
03
2022
accepted:
12
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
22
6
2022
Statut:
epublish
Résumé
The aim of the present study was to understand the mechanism of lethality associated with high dose inhalation of a low-density hydrophobic surface-treated SAS observed in some acute inhalation studies. It was demonstrated that physical obstruction of the upper respiratory tract (nasal cavities) caused the effects observed. Hydrophobic surface-treated SAS was inhaled (flow-past, nose-only) by six Wistar rats (three males and three females) in an acute toxicity study at a concentration of ~500 mg/m
Identifiants
pubmed: 35719607
doi: 10.3389/fpubh.2022.907078
pmc: PMC9204156
doi:
Substances chimiques
Aerosols
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
907078Informations de copyright
Copyright © 2022 Krueger, Weber, Warfving, Vitali, Nolde, Schuster, Bruer, Creutzenberg, Wessely, Stintz, Moise and Kellert.
Déclaration de conflit d'intérêts
NK and TS are employed by Evonik Operations GmbH. KW, NW, and AV are employed by AnaPath Services GmbH. JN is employed by Grace Europe Holding GmbH. GG and OC are employed by Fraunhofer Institute for Toxicology and Experimental Medicine. BW and MS are employed by Technische Universität Dresden. VM is employed by Cabot Corporation. MK is employed by Wacker Chemie AG.
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