Clear Cell Carcinoma of Minor Salivary Glands: The Nasopharynx, an Uncommon Site of Origin.
chemotherapy
clear cell carcinoma
minor salivary glands
nasopharynx
radiotherapy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
accepted:
16
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Clear cell carcinoma is a rare minor salivary gland neoplasm. Its occurrence in the nasopharynx is uncommon. A limited number of cases are reported in the literature. Here, we report an additional case of clear cell carcinoma of the nasopharynx managed by induction chemotherapy followed by chemoradiotherapy, and we describe the clinical presentation, pathological features, and outcome. A 63-year-old man presented with an exophytic, ulcerative, and easily hemorrhagic tumor on the left side of the nasopharynx. A diagnosis of primary, cT4N0M0, clear cell carcinoma of the minor salivary gland was confirmed by a core needle biopsy through nasopharyngoscopy and staging procedures. The patient was treated by induction chemotherapy followed by concomitant chemoradiotherapy with clinical benefit and disease stabilization. Primary salivary gland clear cell carcinoma of the nasopharynx is uncommon. A definitive diagnosis requires an appropriate workup. The optimal treatment is unclear. Chemoradiotherapy might be a good option to manage such cases.
Identifiants
pubmed: 35719756
doi: 10.7759/cureus.25033
pmc: PMC9198607
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e25033Informations de copyright
Copyright © 2022, Arifi et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Auris Nasus Larynx. 2015 Oct;42(5):412-5
pubmed: 25805066
J Cancer Res Ther. 2015 Oct-Dec;11(4):928-30
pubmed: 26881546
Am J Surg Pathol. 1995 Feb;19(2):240-1
pubmed: 7530410
Am J Surg Pathol. 2018 Sep;42(9):1182-1189
pubmed: 29975250
J Natl Compr Canc Netw. 2020 Jul;18(7):873-898
pubmed: 32634781
Genes Chromosomes Cancer. 2011 Jul;50(7):559-70
pubmed: 21484932
Int J Radiat Oncol Biol Phys. 1996 Jun 1;35(3):443-54
pubmed: 8655366
Allergy Rhinol (Providence). 2019 Nov 20;10:2152656719889030
pubmed: 31819807
J Laryngol Otol. 2015 Mar;129 Suppl 2:S95-7
pubmed: 25706172
Otolaryngol Head Neck Surg. 2008 Oct;139(4):592-3
pubmed: 18922351
Int J Surg Pathol. 2014 Oct;22(7):667-72
pubmed: 24619014