Therapeutic Advances in Multiple Sclerosis.
demyelination
disease modifying therapy
multiple sclerosis
neurodegeneration
review
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
11
2021
accepted:
09
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that causes significant disability and healthcare burden. The treatment of MS has evolved over the past three decades with development of new, high efficacy disease modifying therapies targeting various mechanisms including immune modulation, immune cell suppression or depletion and enhanced immune cell sequestration. Emerging therapies include CNS-penetrant Bruton's tyrosine kinase inhibitors and autologous hematopoietic stem cell transplantation as well as therapies aimed at remyelination or neuroprotection. Therapy development for progressive MS has been more challenging with limited efficacy of current approved agents for inactive disease and older patients with MS. The aim of this review is to provide a broad overview of the current therapeutic landscape for MS.
Identifiants
pubmed: 35720070
doi: 10.3389/fneur.2022.824926
pmc: PMC9205455
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
824926Informations de copyright
Copyright © 2022 Yang, Rempe, Whitmire, Dunn-Pirio and Graves.
Déclaration de conflit d'intérêts
JY has received speaker fees for NeurologyLive. TR received grant funding from the National Multiple Sclerosis Society. JG has received grant or contract funding from Biogen, Octave, Novartis, and EMD-Serono and has served on advisory boards for Bayer and Genentech and has received speaker fees from BMS and Alexion. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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