Impact of Body Temperature in Patients With Acute Basilar Artery Occlusion: Analysis of the BASILAR Database.
admission body temperature
basilar artery occlusion
body temperature
endovascular treatment
peak body temperature
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
03
2022
accepted:
16
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
A link between body temperature and stroke outcomes has been established but not for acute basilar artery occlusion. We aimed to determine the association between body temperature and clinical outcomes in patients with acute basilar artery occlusion and temperature management range. We included patients from the Endovascular Treatment for Acute Basilar Artery Occlusion Study (BASILAR) database with records of both admission body temperature (ABT) and peak body temperature (PBT). ABT was defined as the body temperature first measured at the hospital visit, PBT was defined as the highest temperature within 24 h of treatment, and minus body temperature (MBT) was defined as PBT-ABT. The primary clinical outcome was favorable functional outcome, defined as the proportion of patients with a modified Rankin Scale score of 0-3 at 3 months. Secondary outcomes included 3-month mortality, in-hospital mortality, and symptomatic cerebral hemorrhage. A total of 664 patients were enrolled in the study; 74.7% were men, with a median age of 65 (interquartile range, 57.25-74) years. In all patients, multivariate analysis indicated that PBT and MBT were independent predictors of favorable functional outcome [odds ratio (OR), 0.57 (95% CI, 0.43-0.77); OR, 0.68 (95% CI, 0.52-0.88), respectively], and higher ABT, PBT, and MBT were associated with an increased 3-month mortality [OR, 1.47 (95% CI, 1.03-2.10), OR, 1.58 (95% CI, 1.28-1.96), OR, 1.35 (95% CI, 1.11-1.65), respectively]. Proportional odds models demonstrated that when ABT, PBT, MBT were in the range of <37.5, <38.9, and -0.6-2.7°C, respectively, the benefit of the endovascular treatment is clearly greater than that of standard medical treatment in terms of favorable functional outcome. Body temperature is an independent predictor of clinical outcome in patients with acute basilar artery occlusion. It is necessary to control the patient body temperature within the appropriate range in clinical settings. Chinese Clinical Trial Registry ChiCTR1800014759. Registered 03 February 2018. Retrospectively registered.
Sections du résumé
Background
UNASSIGNED
A link between body temperature and stroke outcomes has been established but not for acute basilar artery occlusion. We aimed to determine the association between body temperature and clinical outcomes in patients with acute basilar artery occlusion and temperature management range.
Methods
UNASSIGNED
We included patients from the Endovascular Treatment for Acute Basilar Artery Occlusion Study (BASILAR) database with records of both admission body temperature (ABT) and peak body temperature (PBT). ABT was defined as the body temperature first measured at the hospital visit, PBT was defined as the highest temperature within 24 h of treatment, and minus body temperature (MBT) was defined as PBT-ABT. The primary clinical outcome was favorable functional outcome, defined as the proportion of patients with a modified Rankin Scale score of 0-3 at 3 months. Secondary outcomes included 3-month mortality, in-hospital mortality, and symptomatic cerebral hemorrhage.
Results
UNASSIGNED
A total of 664 patients were enrolled in the study; 74.7% were men, with a median age of 65 (interquartile range, 57.25-74) years. In all patients, multivariate analysis indicated that PBT and MBT were independent predictors of favorable functional outcome [odds ratio (OR), 0.57 (95% CI, 0.43-0.77); OR, 0.68 (95% CI, 0.52-0.88), respectively], and higher ABT, PBT, and MBT were associated with an increased 3-month mortality [OR, 1.47 (95% CI, 1.03-2.10), OR, 1.58 (95% CI, 1.28-1.96), OR, 1.35 (95% CI, 1.11-1.65), respectively]. Proportional odds models demonstrated that when ABT, PBT, MBT were in the range of <37.5, <38.9, and -0.6-2.7°C, respectively, the benefit of the endovascular treatment is clearly greater than that of standard medical treatment in terms of favorable functional outcome.
Conclusions
UNASSIGNED
Body temperature is an independent predictor of clinical outcome in patients with acute basilar artery occlusion. It is necessary to control the patient body temperature within the appropriate range in clinical settings.
Trial Registration
UNASSIGNED
Chinese Clinical Trial Registry ChiCTR1800014759. Registered 03 February 2018. Retrospectively registered.
Identifiants
pubmed: 35720074
doi: 10.3389/fneur.2022.907410
pmc: PMC9205153
doi:
Types de publication
Journal Article
Langues
eng
Pagination
907410Informations de copyright
Copyright © 2022 Zhang, Li, Zhang, Lei, Deng, Zeng, Yu, Wu, Peng, Tian, Zhu, Hu, Hong, Li, Ge, Xu, Ju, Yang, Pan, Zi and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet Neurol. 2009 May;8(5):434-40
pubmed: 19297248
Lancet. 1996 Feb 17;347(8999):422-5
pubmed: 8618482
J Stroke Cerebrovasc Dis. 2008 May-Jun;17(3):141-6
pubmed: 18436155
Stroke. 2015 Oct;46(10):2981-6
pubmed: 26330447
J Neurointerv Surg. 2019 Dec;11(12):1174-1180
pubmed: 31239331
Acta Neurol Scand. 2006 Jul;114(1):23-8
pubmed: 16774623
Stroke. 2009 Sep;40(9):3051-9
pubmed: 19644066
Acta Neurol Scand. 2010 Dec;122(6):414-7
pubmed: 20199522
Intensive Care Med. 2015 May;41(5):823-32
pubmed: 25643903
J Am Coll Cardiol. 2016 Jun 7;67(22):2631-44
pubmed: 27256835
Stroke. 1998 Feb;29(2):529-34
pubmed: 9472901
Stroke. 2000 Feb;31(2):404-9
pubmed: 10657413
J Neurol Neurosurg Psychiatry. 2020 Oct;91(10):1055-1059
pubmed: 32934109
Ann Neurol. 1990 Jul;28(1):26-33
pubmed: 2375631
Stroke. 2021 Jul;52(7):2220-2228
pubmed: 34078106
AJNR Am J Neuroradiol. 2010 Mar;31(3):454-8
pubmed: 20075087
Stroke. 2020 Apr;51(4):1218-1225
pubmed: 32102631
PLoS One. 2015 Oct 16;10(10):e0140777
pubmed: 26473959
BMC Neurol. 2016 Nov 21;16(1):233
pubmed: 27871258
Stroke. 2016 Dec;47(12):2888-2895
pubmed: 27834742
BMC Neurol. 2012 Oct 18;12:123
pubmed: 23075282
Stroke. 2001 Feb;32(2):413-7
pubmed: 11157175
JAMA Neurol. 2019 May 1;76(5):571-579
pubmed: 30657812
Neurology. 2021 Nov 30;97(22):e2152-e2163
pubmed: 34649885
AJNR Am J Neuroradiol. 2017 Jan;38(1):46-51
pubmed: 27758774
Lancet. 2016 Apr 23;387(10029):1723-31
pubmed: 26898852
Stroke. 2002 Jul;33(7):1759-62
pubmed: 12105348
Eur Stroke J. 2019 Sep;4(3):254-262
pubmed: 31984233
JAMA Neurol. 2020 May 1;77(5):561-573
pubmed: 32080711